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UniProtKB/Swiss-Prot entry Q6GDS2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHD_STAAR
Primary accession number Q6GDS2
Secondary accession numbers None
Integrated into Swiss-Prot on December 20, 2005
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 31)
Name and origin of the protein
Protein name D-lactate dehydrogenase
Synonyms D-LDH
EC 1.1.1.28
D-specific D-2-hydroxyacid dehydrogenase
Gene name
Name: ldhD
Synonyms: ddh
OrderedLocusNames: SAR2605
From
Staphylococcus aureus (strain MRSA252) [TaxID: 282458] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0402521101; PubMed=15213324 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.";
Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571856; CAG41584.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_041951.1; -.
3D structure databases
ModBase Q6GDS2.
Enzyme and pathway databases
BioCyc SAUR282458:SAR2605-MON; -.
Ontologies
GO
GO:0008720; Molecular function: D-lactate dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR006139; D-isomer_2_OHA_DHase.
IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00389; 2-Hacid_dh; 1.
PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1.
PS00670; D_2_HYDROXYACID_DH_2; 1.
PS00671; D_2_HYDROXYACID_DH_3; 1.
BLOCKS Q6GDS2.
Genome annotation databases
GeneID 2859266; -.
GenomeReviews BX571856_GR; SAR2605.
KEGG sar:SAR2605; -.
Phylogenomic databases
HOGENOM Q6GDS2; -.
Genome annotation databases
CMR Q6GDS2; SAR2605.
Other
ProtoNet Q6GDS2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   330  330     D-lactate dehydrogenase. PRO_0000075962
ACT_SITE   235   235        By similarity. 
ACT_SITE   264   264        By similarity. 
ACT_SITE   296   296        Proton donor (By similarity). 
Sequence information
Length: 330 AA [This is the length of the unprocessed precursor] Molecular weight: 36756 Da [This is the MW of the unprocessed precursor] CRC64: 4B36154D1B8EAE27 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTKIMFFGTR DYEKEMALNW GKKNNVEVTT SKELLSSATV DQLKDYDGVT TMQFGKLEND 

        70         80         90        100        110        120 
VYPKLESYGI KQIAQRTAGF DMYDLDLAKK HNIVISNVPS YSPETIAEYS VSIALQLVRR 

       130        140        150        160        170        180 
FPDIERRVQA HDFTWQAEIM SKPVKNMTVA IIGTGRIGAA TAKIYAGFGA TITAYDAYPN 

       190        200        210        220        230        240 
KDLDFLTYKD SVKEAIKDAD IISLHVPANK ESYHLFDKTM FDHVKKGAIL VNAARGAVIN 

       250        260        270        280        290        300 
TPDLIDAVND GTLLGAAIDT YENEAAYFTN DWTNKDIDDK TLLELIEHER ILVTPHIAFF 

       310        320        330 
SDEAVQNLVE GGLNAALSVI NTGTCETRLN 

Q6GDS2 in FASTA format

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