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UniProtKB/Swiss-Prot entry Q6GCM3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ISPD1_STAAS
Primary accession number Q6GCM3
Secondary accession numbers None
Integrated into Swiss-Prot on December 21, 2004
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1
Synonyms EC 2.7.7.60
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 1
MEP cytidylyltransferase 1
MCT 1
Gene name
Name: ispD1
OrderedLocusNames: SAS0227
From
Staphylococcus aureus (strain MSSA476) [TaxID: 282459] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0402521101; PubMed=15213324 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.";
Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571857; CAG41996.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_042350.1; -.
3D structure databases
ModBase Q6GCM3.
Enzyme and pathway databases
BioCyc SAUR282459:SAS0227-MON; -.
Ontologies
GO
GO:0050518; Molecular function: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0016114; Biological process: terpenoid biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00108; -; 1.
PBIL [Tree]
InterPro IPR001228; ISPD_synthase.
Graphical view of domain structure.
Pfam PF01128; IspD; 1.
Pfam graphical view of domain structure.
PROSITE PS01295; ISPD; 1.
BLOCKS Q6GCM3.
ProtoNet Q6GCM3.
Genome annotation databases
GeneID 2861974; -.
GenomeReviews BX571857_GR; SAS0227.
KEGG sas:SAS0227; -.
Phylogenomic databases
HOGENOM Q6GCM3; -.
Genome annotation databases
CMR Q6GCM3; SAS0227.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Isoprene biosynthesis; Nucleotidyltransferase; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   238  238     2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1. PRO_0000075621
SITE   14    14  1     Transition state stabilizer (By similarity). 
SITE   22    22  1     Transition state stabilizer (By similarity). 
SITE   160   160  1     Positions MEP for the nucleophilic attack (By similarity). 
SITE   217   217  1     Positions MEP for the nucleophilic attack (By similarity). 
Sequence information
Length: 238 AA [This is the length of the unprocessed precursor] Molecular weight: 26627 Da [This is the MW of the unprocessed precursor] CRC64: F21440DA33D18AA7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MIYAGILAGG IGSRMGNVPL PKQFLDIDNK PILIHTIEKF ILVSEFNEII IATPAQWISH 

        70         80         90        100        110        120 
TQDILKKYNI TDQRVKVVAG GTDRNETIMN IIDYIRNVNG INNDDVIVTH DAVRPFLTQR 

       130        140        150        160        170        180 
IIKENIEVAE KYGAVDTVIE AIDTIVMSKD KQNIHSIPVR NEMYQGQTPQ SFNIKLLQDS 

       190        200        210        220        230 
YRALSSAQKE ILSDACKIIV ESGHPVKLVR GELYNIKVTT PYDLKVANAI IQGDIADD 

Q6GCM3 in FASTA format

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