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UniProtKB/Swiss-Prot entry Q6G8N2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_STAAS
Primary accession number Q6G8N2
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2005
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 28)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
Synonyms: citC
OrderedLocusNames: SAS1622
From
Staphylococcus aureus (strain MSSA476) [TaxID: 282459] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0402521101; PubMed=15213324 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.";
Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571857; CAG43424.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_043741.1; -.
3D structure databases
SMR Q6G8N2; 3-421.
ModBase Q6G8N2.
Enzyme and pathway databases
BioCyc SAUR282459:SAS1622-MON; -.
Family and domain databases
InterPro IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00183; prok_nadp_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q6G8N2.
Genome annotation databases
GeneID 2864056; -.
GenomeReviews BX571857_GR; SAS1622.
KEGG sas:SAS1622; -.
Phylogenomic databases
HOGENOM Q6G8N2; -.
Genome annotation databases
CMR Q6G8N2; SAS1622.
Other
ProtoNet Q6G8N2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   422  422     Isocitrate dehydrogenase [NADP]. PRO_0000083563
NP_BIND   344   350  7     NADP (By similarity). 
METAL   310   310        Magnesium or manganese (By similarity). 
BINDING   94    94        NADP (By similarity). 
BINDING   103   103        Substrate (By similarity). 
BINDING   105   105        Substrate (By similarity). 
BINDING   109   109        Substrate (By similarity). 
BINDING   119   119        Substrate (By similarity). 
BINDING   143   143        Substrate (By similarity). 
BINDING   357   357        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   396   396        NADP (By similarity). 
BINDING   400   400        NADP (By similarity). 
SITE   150   150  1     Critical for catalysis (By similarity). 
SITE   220   220  1     Critical for catalysis (By similarity). 
Sequence information
Length: 422 AA [This is the length of the unprocessed precursor] Molecular weight: 46437 Da [This is the MW of the unprocessed precursor] CRC64: 11AE808D40093BC7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN GEKRIEWKEV 

        70         80         90        100        110        120 
LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG IRSLNVALRQ ELDLFTCLRP 

       130        140        150        160        170        180 
VRWFKGVPSP VKRPQDVDMV IFRENTEDIY AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF 

       190        200        210        220        230        240 
PETSGIGIKP VSKEGTERLV RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL 

       250        260        270        280        290        300 
SEFGDQVFTW QQYDEIVEKE GRDAANAAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD 

       310        320        330        340        350        360 
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY AGLNKVNPSS 

       370        380        390        400        410        420 
VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR LMDGAEEVST SAFADELIKN 


LK
Q6G8N2 in FASTA format

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