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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0402521101; PubMed=15213324 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G.,
Feil E.J.,
Lindsay J.A.,
Peacock S.J.,
Day N.P.J.,
Enright M.C.,
Foster T.J.,
Moore C.E.,
Hurst L.,
Atkin R.,
Barron A.,
Bason N.,
Bentley S.D.,
Chillingworth C.,
Chillingworth T.,
Churcher C.,
Clark L.,
Corton C.,
Cronin A., ![]()
Doggett J.,
Dowd L.,
Feltwell T.,
Hance Z.,
Harris B.,
Hauser H.,
Holroyd S.,
Jagels K.,
James K.D.,
Lennard N.,
Line A.,
Mayes R.,
Moule S.,
Mungall K.,
Ormond D.,
Quail M.A.,
Rabbinowitsch E.,
Rutherford K.M.,
Sanders M.,
Sharp S.,
Simmonds M.,
Stevens K.,
Whitehead S.,
Barrell B.G.,
Spratt B.G.,
Parkhill J.;
"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.";
Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
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- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in lactose transport.
- CATALYTIC ACTIVITY: Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Probable).
- DOMAIN: The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
- DOMAIN: The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
- SIMILARITY: Contains 1 PTS EIIB type-3 domain.
- SIMILARITY: Contains 1 PTS EIIC type-3 domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 570 AA [This is the length of the unprocessed precursor] |
Molecular weight: 62432 Da [This is the MW of the unprocessed precursor] |
CRC64: 587192287079BE58 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MMQKLIAQIE KGKPFFEKLS RNIYLRAIRD GFISAMPVIL FSSIFLLIAY VPNIFGFKWD
70 80 90 100 110 120
KGMEAILMKP YNYTMGLVAF LVAGTTAKSL TDSFNRKLES TNQINFISTM LAAMCGFLFL
130 140 150 160 170 180
ASDPAKDGGF LSAFMGTKGL LTAFLSAFVT VIVYNFCVKR NITIKMPKEV PPNISQVFKD
190 200 210 220 230 240
LIPFSAVIII LYALDLVIRN SFKSNVAEGI LKLFEPLFTA ADGWIGVTII FGAFALFWFV
250 260 270 280 290 300
GIHGPSIVEP AIAAITYANI EANFKLLQAG EHADKIITSG TQMFIVTFGG TGATLVVPFM
310 320 330 340 350 360
FMWMTKSKRN KAIGRASVVP TFFGVNEPIL FGAPLVLNPV FFIPFVLAPI VNVWIFKLFV
370 380 390 400 410 420
EVLGMNSFSV NLPWTTPGPL GIIMGTGFGL WSFVLAITLI VVDIIIYYPF LKVYDSEILD
430 440 450 460 470 480
EEEGRKESNS DLKEKVAANF DTKKADSILA ASGVSDDAAK ASNITEQTNV LVLCAGGGTS
490 500 510 520 530 540
GLLANALNKA AEEYHVPVKA AAGGYGAHMD IMKEYQLIIL APQVASNYED IKQDTDRLGI
550 560 570
KLAKTQGAEY IKLTRDGQAA LDFVQQQFEN
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Q6G7C4 in FASTA format |
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ExPASy Home page
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