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UniProtKB/Swiss-Prot entry Q6G584

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SAHH_BARHE
Primary accession number Q6G584
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 2005
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    October 14, 2008 (Entry version 30)
Name and origin of the protein
Protein name Adenosylhomocysteinase
Synonyms EC 3.3.1.1
S-adenosyl-L-homocysteine hydrolase
AdoHcyase
Gene name
Name: ahcY
OrderedLocusNames: BH00310
From
Bartonella henselae (Rochalimaea henselae) [TaxID: 38323] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bartonellaceae; Bartonella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49882 / Houston 1;
DOI=10.1073/pnas.0305659101; PubMed=15210978 [NCBI, ExPASy, EBI, Israel, Japan]
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.;
"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae.";
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX897699; CAF26847.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_032900.1; -.
3D structure databases
ModBase Q6G584.
Enzyme and pathway databases
BioCyc BHEN283166:BH00310-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004013; Molecular function: adenosylhomocysteinase activity (inferred from electronic annotation from HAMAP).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00563; -; 1.
PBIL [Tree]
InterPro IPR000043; Ad_hcy_hydrolase.
IPR015878; Ado_hCys_hydrolase_NAD-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.1480; Ad_hcy_hydrolase; 1.
PANTHER PTHR23420; Ad_hcy_hydrolase; 1.
Pfam PF05221; AdoHcyase; 1.
PF00670; AdoHcyase_NAD; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001109; Ad_hcy_hydrolase; 1.
TIGRFAMs TIGR00936; ahcY; 1.
PROSITE PS00738; ADOHCYASE_1; 1.
PS00739; ADOHCYASE_2; 1.
BLOCKS Q6G584.
ProtoNet Q6G584.
Genome annotation databases
GeneID 2866066; -.
GenomeReviews BX897699_GR; BH00310.
KEGG bhe:BH00310; -.
NMPDR fig|283166.1.peg.28; -.
Phylogenomic databases
HOGENOM Q6G584; -.
Genome annotation databases
CMR Q6G584; BH00310.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   465  465     Adenosylhomocysteinase. PRO_0000116944
REGION   218   383  166     NAD binding (By similarity). 
BINDING   56    56        Substrate (By similarity). 
BINDING   131   131        Substrate (By similarity). 
BINDING   191   191        Substrate (By similarity). 
BINDING   221   221        Substrate (By similarity). 
BINDING   225   225        Substrate (By similarity). 
Sequence information
Length: 465 AA [This is the length of the unprocessed precursor] Molecular weight: 51029 Da [This is the MW of the unprocessed precursor] CRC64: 45F2E7583A655434 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTAQDYVVKD IALAAYGRKE LDIAETEMPG LMACREEFSS SQPLRGARIS GSLHMTIQTA 

        70         80         90        100        110        120 
VLIETLKAIG ANVRWSSSNI FSTQDHAAAA IAATGTPVFA VKGETLEEYW TYIDAIFQWP 

       130        140        150        160        170        180 
DGNPSNLILD DGADATNYIL MGSRAETNKD ILSHPKTEEE ELFFKQIQRR MEATPGFFTR 

       190        200        210        220        230        240 
QRAAIKGISE ETTTGVHRLH QLQKEGLLPF PAININDSVT KSKFDNKYGC RESLVDGIRR 

       250        260        270        280        290        300 
ATDVMIAGKT AIVCGYGDVG KGSAASLSGA GARVKVTEID PICALQAAMD GYEVVNLDDA 

       310        320        330        340        350        360 
ASSADIIITT TGNKDIVRLD HMRKVKDMCI LGNIGHFDNE IQVAALQNLP WTNIKPQVDM 

       370        380        390        400        410        420 
ITFPDGKRII LLSEGRLLNL GNATGHPSFV MSASFTNQVL AQIELFTRSG HYKNEVTVLP 

       430        440        450        460 
KYLDEKVARL HLDQLGIKLT TLSQEQAAYI GVTPQGPYKP DHYRY
Q6G584 in FASTA format

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