FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

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Cross-references

Sequence databases

EMBL

CR380949; CAG58222.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

XP_445316.1; -.

3D structure databases

SMR

Q6FWS8; 19-251.

ModBase

Q6FWS8.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0051537;	Molecular function: 2 iron, 2 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051538;	Molecular function: 3 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051539;	Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008177;	Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

Pfam

PF00111; Fer2; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

2886893; -.

KEGG

cgr:CAGL0C03223g; -.

Phylogenomic databases

HOGENOM

Q6FWS8; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion.`
`CHAIN`	`? 253`		`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial.`	`PRO_0000010348`
`DOMAIN`	`23 114`	`92`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`156 186`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`74 74`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`79 79`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`82 82`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`94 94`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`166 166`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`169 169`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`172 172`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`176 176`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`223 223`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`229 229`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`233 233`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`BINDING`	`181 181`		`Ubiquinone; shared with DHSD (By similarity).`

Sequence information

Length: 253 AA [This is the length of the unprocessed precursor]

Molecular weight: 29054 Da [This is the MW of the unprocessed precursor]

CRC64: 2557E1940B402EA3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFMLRVSRRG LATATSVPRL KTFKIYRWNP DKPTEKPHLQ EYKVDLEDCG PMVLDALLKI 

        70         80         90        100        110        120 
KNEQDATLTF RRSCREGICG SCAMNIGGAN TLACLCKIDQ DESKTTKIYP LPHMFIVKDL 

       130        140        150        160        170        180 
VPDLTGFYQQ YKSIQPYLQR TDYPADGKEV LQSIDDRKKL DGLYECILCA CCSTSCPSYW 

       190        200        210        220        230        240 
WNQEEYLGPA VLMQAYRWLI DSRDQATKAR RTMLQNSMSL YRCHTIMNCT RTCPKGLNPG 

       250 
RSIAEIKKQL AFD

Q6FWS8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools