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UniProtKB/Swiss-Prot entry Q6FW88

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PMIP_CANGA
Primary accession number Q6FW88
Secondary accession numbers None
Integrated into Swiss-Prot on June 10, 2008
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 30)
Name and origin of the protein
Protein name Mitochondrial intermediate peptidase [Precursor]
Synonyms MIP
EC 3.4.24.59
Octapeptidyl aminopeptidase
Gene name
Name: OCT1
OrderedLocusNames: CAGL0D02112g
From
Candida glabrata (Yeast) (Torulopsis glabrata) [TaxID: 5478] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
  • FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
  • CATALYTIC ACTIVITY: Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.
  • COFACTOR: Binds 1 zinc ion (By similarity).
  • SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
  • SIMILARITY: Belongs to the peptidase M3 family [view classification].
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR380950; CAG58417.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_445506.1; -.
3D structure databases
ModBase Q6FW88.
Protein family/group databases
MEROPS M03.006; -.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001567; Pept_M3A_M3B.
IPR006025; Pept_M_Zn_BS.
Graphical view of domain structure.
Pfam PF01432; Peptidase_M3; 1.
Pfam graphical view of domain structure.
PROSITE PS00142; ZINC_PROTEASE; 1.
BLOCKS Q6FW88.
ProtoNet Q6FW88.
Genome annotation databases
GeneID 2887167; -.
KEGG cgr:CAGL0D02112g; -.
Phylogenomic databases
HOGENOM Q6FW88; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Mitochondrion; Protease; Transit peptide; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    37  37     Mitochondrion (Potential). 
CHAIN   38   761  724     Mitochondrial intermediate peptidase. PRO_0000338577
ACT_SITE   548   548        By similarity. 
METAL   547   547        Zinc; catalytic (By similarity). 
METAL   551   551        Zinc; catalytic (By similarity). 
METAL   554   554        Zinc; catalytic (By similarity). 
Sequence information
Length: 761 AA [This is the length of the unprocessed precursor] Molecular weight: 87333 Da [This is the MW of the unprocessed precursor] CRC64: 89CA8567A26EC72E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLIQKILLNK EISRLPRILS ILNYTGLRWL SGSSGRNTTE LQRIFDDSKY WQSLSENTTQ 

        70         80         90        100        110        120 
YTKETGLFKN PYLTSTDGLR QFSHDSLHKA HKLAEILRNS VSKEEKVHYI MNLDQLSDTL 

       130        140        150        160        170        180 
CRVIDLCEFL RSAHPDQSYV EAAQMCHEEM FEFMNVLNTD VVLCNKLKEV LEDPEILKVL 

       190        200        210        220        230        240 
SEEERKVGEI LLDDFEKSGI YMKAGIREQF IELSQQISVI GQEFINNTDY VAKEFIKVKR 

       250        260        270        280        290        300 
DEMDKSGISP LLTARLNRDL TGKYYKIPTY GQIPLQILKS CPDEDIRKEV WAALHNCPKA 

       310        320        330        340        350        360 
QIQRLNQLVR LRVILSNLLG KQSYSDYQLD NKMAGSPENV KGFIKTLMNV TKPLAARELE 

       370        380        390        400        410        420 
FIARDKLNAP DSRHMSDNEI LSIVKPWDKN YFSSKYDSDN EMAMIRDEQL RYYFSLGNVI 

       430        440        450        460        470        480 
NGLSELFKRI YGITLQPSRT ENGETWSPDV RRLDVISEEE GLVGVIYCDL FERVGKISNP 

       490        500        510        520        530        540 
AHFTVCCSRQ VYPDENDFTT IQTGQNSDGT VFQLPVISLV CNFSTVALPN GNRTCFLHMN 

       550        560        570        580        590        600 
EIETLFHEMG HAMHSMLGRT RLQNISGTRC ATDFVELPSI LMEHFARDIR VLRTIGSHYE 

       610        620        630        640        650        660 
TSEPAPEALL NDYLDKTQFL QHCETYSQAK MAMLDQKLHG SFSLSDIERI DSAKIYQKLE 

       670        680        690        700        710        720 
TRLQVLADDE SNWCGRFGHL FGYGATYYSY LFDRAIASKV WDSLFKDDPF NRTGGEKFKE 

       730        740        750        760 
RVLKWGGLKN PWSCIADVLE KPDLAKGGAE AMTYIGDSED L
Q6FW88 in FASTA format

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View entry in raw text format (no links)
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