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UniProtKB/Swiss-Prot entry Q6FRZ9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATM_CANGA
Primary accession number Q6FRZ9
Secondary accession numbers None
Integrated into Swiss-Prot on March 21, 2006
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 37)
Name and origin of the protein
Protein name Serine/threonine-protein kinase TEL1
Synonyms EC 2.7.11.1
DNA-damage checkpoint kinase TEL1
Telomere length regulation protein 1
ATM homolog
Gene name
Name: TEL1
OrderedLocusNames: CAGL0H04609g
From
Candida glabrata (Yeast) (Torulopsis glabrata) [TaxID: 5478] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR380954; CAG59928.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_446995.1; -.
3D structure databases
ModBase Q6FRZ9.
Family and domain databases
InterPro IPR015519; Ataxia_Telang_Mut.
IPR003152; FATC.
IPR000403; PI3/4_kinase_cat.
IPR014009; PIK_FAT.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1070.11; PI3/4_kinase_cat; 1.
PANTHER PTHR11139:SF3; Ataxia_Telang_Mut; 1.
Pfam PF02260; FATC; 1.
PF00454; PI3_PI4_kinase; 1.
Pfam graphical view of domain structure.
SMART SM00146; PI3Kc; 1.
SMART graphical view of domain structure.
PROSITE PS51189; FAT; 1.
PS51190; FATC; 1.
PS00915; PI3_4_KINASE_1; 1.
PS00916; PI3_4_KINASE_2; 1.
PS50290; PI3_4_KINASE_3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q6FRZ9.
Genome annotation databases
GeneID 2888643; -.
KEGG cgr:CAGL0H04609g; -.
Phylogenomic databases
HOGENOM Q6FRZ9; -.
Other
ProtoNet Q6FRZ9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chromatin regulator; Chromosomal protein; Complete proteome; DNA damage; DNA repair; Kinase; Nucleus; Serine/threonine-protein kinase; Telomere; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   2763  2763     Serine/threonine-protein kinase TEL1. PRO_0000227699
DOMAIN   1715   2294  580     FAT. 
DOMAIN   2429   2763  335     PI3K/PI4K. 
DOMAIN   2731   2763  33     FATC. 
Sequence information
Length: 2763 AA [This is the length of the unprocessed precursor] Molecular weight: 319038 Da [This is the MW of the unprocessed precursor] CRC64: 3CF36DFF08660AD7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MENYQIRTLQ DQLTSSKLRD RNAGLQELQS ILKDNPGFIA NEQINGLLNT LLSLLENEAG 

        70         80         90        100        110        120 
KYIDSIEDDT DSRQRKENIS ISRFSNITYT LRLFIETVIE KFKLSHLKLT ISAVKDLFYN 

       130        140        150        160        170        180 
DARIIVPVIN DVTYCILAIV KSEIFGNKIG PSQWLDVAEY TLWLIKITSS NRSNIRALTN 

       190        200        210        220        230        240 
SLDTFYVLLI KGSISLSKVA KEALVIITNL IVFEKGETAT TNVLLSISSN LVARLHCQHY 

       250        260        270        280        290        300 
YDTTSLIIEC WKLYTRIGKT NNFNLLNDIS KIDIFGGGLL QNQIPIMPGQ EIMGSRISHS 

       310        320        330        340        350        360 
VVLSTLQDYI PMKVKEMLDV DHSLTIGIYD DLNNSNMDLT YNTFAKTHCK DLAWLRLFGL 

       370        380        390        400        410        420 
YDTLCLYYRL SNQERENNAT QILKKIKYEG SLQSNLNQCN SLLDYSQSLL ESGDPLIQLL 

       430        440        450        460        470        480 
GCKLFFLLNL DHPIACNTEL IDRLCINTNN ISLTSWHLAC IFTNISYDLW NFDETLYLKV 

       490        500        510        520        530        540 
LKYITPLLST SEVNIMACLI FNKLLHSLTR EPIDELSSLV NSIIASPDSV LPIEISSVTC 

       550        560        570        580        590        600 
EAWQHIFVFA INNLKVDNSL LLDSFSKWIN HNITQTIHIE HLKLIFEFFL WSLDVVVGST 

       610        620        630        640        650        660 
SHNKQHNTYN LLNLKTSDSA LAIWYFYENQ RKFLTQTIQT SSQASVNTKS MVCPITSTNI 

       670        680        690        700        710        720 
KIQWLLNIID NYFTTSKNHS LKYTFAISLI YFINFIEKSG KVYTYLNQEL NQRLNSILIE 

       730        740        750        760        770        780 
LDFLSFDKWE EGKQFIEIIC NQETFFNRLH NDVVFKDNIL LSLINLFEKE YSHFLNADNG 

       790        800        810        820        830        840 
STAKTGNDIY LNQRSILRFR TDIKLMTQFF TCVDSNVPGK IGIYLDRLLL YSMGPNESLV 

       850        860        870        880        890        900 
LDELLSWVTN PSNNQYYEVH SLEKLCQFLA KSLLNSKYQL SDFSMIRLGL FLTSTIELWV 

       910        920        930        940        950        960 
NVKYNILNSD CNDFLIWITN NLVQNNFGET GTFVVLIRLF ISVLKHNSTV NSSCAIKTQD 

       970        980        990       1000       1010       1020 
LYSMLIFCMR NVAYSTLGNI VDELKAYMSK KSHKNRKTIL DDLVELFEPM PESVEKAASS 

      1030       1040       1050       1060       1070       1080 
CFVLFGLLDC NDTNFVYTLD IFSNYGNIPH ISFFLKKAVK NYVNNYYQGN KIQLLNVHIL 

      1090       1100       1110       1120       1130       1140 
EVIRQWTKRN DTDRQLYFNS VIGSLFGFGS IQEFERQYNR EICALIFSRS DSESLERNFF 

      1150       1160       1170       1180       1190       1200 
SDRNTSKCEM LRRSLYLLIP LSYYDNGVGD MVFNKLKDSF RGQLESVLSS NFIIVMRYAL 

      1210       1220       1230       1240       1250       1260 
KLCDCSDYTS VLNEMQRPNQ SSSLLELFMD SEMKNAINRM NIYITVHSVI KIFKNCGRSR 

      1270       1280       1290       1300       1310       1320 
QTLLLDLRTL ILWIISDIQK SESSWEQNNH LRQLQLLVFL YEDTFLQSVL HIELMNWLSY 

      1330       1340       1350       1360       1370       1380 
LLKIENIEAD VFLLLNCLLS LIKPNSLDKP DSLTLFFLNV LHFYVRNKEC LKIGDEDMNM 

      1390       1400       1410       1420       1430       1440 
LSNNLSTVNS IALKLLTNGQ VTDLIYNQVG DLTSQMYFAE EVELFALLMT FAPPMPDYVS 

      1450       1460       1470       1480       1490       1500 
HKMNKKFIEY VYKSNNLIDI DNFSLWFSDY STQYSSLILE LEENSSFCEK DGFGIDDMEI 

      1510       1520       1530       1540       1550       1560 
VYDFSDSAVS AMYSVLFRSL ISIKPTIGFK SFALSNIICH LISINILKDK DLLSKFLRAT 

      1570       1580       1590       1600       1610       1620 
KMKIAFSAKE IDETIIEHFG KSNCGCVISE HYLESEFFDT NIPYKDWLVK LCMFFISQIS 

      1630       1640       1650       1660       1670       1680 
LNSKEIQWFI PLCYESMDFC KQNVCIFFLA AFSFDHRRMS STWKHIFSRL NDLTMASDCL 

      1690       1700       1710       1720       1730       1740 
AKLTLLLSFI RLIRSGALQG RKEYSNLYQK IEFKGVIDAA LKIKDSKFAL QLFEEAYMCE 

      1750       1760       1770       1780       1790       1800 
NGDYDVALLT SIYEQLDDVD MLYALPTPIS LNGFIKNANR LSPHSLKALQ LNGAYFDANF 

      1810       1820       1830       1840       1850       1860 
NHLVDNGSHQ LVNTLTGMGF NALADIADLR TSCDNPADAY LRCLQLDKWD LPKPKAIDCK 

      1870       1880       1890       1900       1910       1920 
IVSFYNTAYD LRNTNIEFVD LLQNAEIQLY KAKANFSSKL EWFETIREYV KTKRAIISLK 

      1930       1940       1950       1960       1970       1980 
TDTDISRFKI DHVINPDRYL ENALISDIKI NWQFRYLMLK IYVEREKFAN EAMKCIPILE 

      1990       2000       2010       2020       2030       2040 
LIHQTELSVD FHIQQTSLSR ILSMEAAMKR FHIADTNLVE QLSRHVSYVT ALALREFGET 

      2050       2060       2070       2080       2090       2100 
KAPLTILSKL LSDKSYKLNY NTFVSDDEVR AQLIWDSYQA KVKSGIQIFE NDVEHWDVSI 

      2110       2120       2130       2140       2150       2160 
NNIRSAPDTI YKVANFLNLE ISRLNGSDQL KEKQKSYRRT RQELKDIESV VKSSNLSNEE 

      2170       2180       2190       2200       2210       2220 
LLVGQKHYHN LKTHMENDRL AIENICLTRK KLIKRALDYY VQILILTNNY DYDVLDRFCG 

      2230       2240       2250       2260       2270       2280 
LWFENDDDDD INTDLTSKLS QIPTWKFLPW VNQFTSKLSL LKSKFQKQLW YIMKRLLYKL 

      2290       2300       2310       2320       2330       2340 
PFETGYAVIN LQLYEKYSDK LDEKISEKIK AANLIFDQLQ NSQISVKEGE YLRTIQEFCY 

      2350       2360       2370       2380       2390       2400 
ATLEIAELKV KGKNAQISLE TLNIGRYWIT ELPKKNLPLP TVTRTINSSQ YTLDSSRNIV 

      2410       2420       2430       2440       2450       2460 
KVIGNITITS TGLSLPKVMT LLLSDGSRHK VVIKYGSDDL RQDAIMEQVF QQVNKIFGKD 

      2470       2480       2490       2500       2510       2520 
VEMRRSDLHM RTYNVVPLGP KAGLIEFVNN SLSLHSILTD IHKDDNYSWL EARRSMKDVQ 

      2530       2540       2550       2560       2570       2580 
SKSDKERILT YLDITKKISP KFRNFFFNSF IDANGWICAK RKYTKGVATS SMVGYILGLG 

      2590       2600       2610       2620       2630       2640 
DRHLNNILID TTTGEPIHID LGIAFDQGRL LKIPELVPFR LTRDIIDGFG ITGVEGIFRR 

      2650       2660       2670       2680       2690       2700 
TCEQVLNVLS RDSEKVMCVL NILKWDPLYS WAVSPFKKHK YMYDDNLEGH MTTATNNSKV 

      2710       2720       2730       2740       2750       2760 
IERKLTPKLD SDENQQSYRA LKGVQEKLDR NGLTIEATVE KLIQEAVDES NLALIFNGWS 


PFY
Q6FRZ9 in FASTA format

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