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UniProtKB/Swiss-Prot entry Q6F7X1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ACIAD
Primary accession number Q6F7X1
Secondary accession numbers None
Integrated into Swiss-Prot on August 16, 2004
Sequence was last modified on July 19, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 33)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: ACIAD3155
From
Acinetobacter sp. (strain ADP1) [TaxID: 62977] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/nar/gkh910; PubMed=15514110 [NCBI, ExPASy, EBI, Israel, Japan]
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium.";
Nucleic Acids Res. 32:5766-5779(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR543861; CAG69844.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_047666.1; -.
3D structure databases
SMR Q6F7X1; 2-327.
ModBase Q6F7X1.
Enzyme and pathway databases
BioCyc ASP62977:ACIAD3155-MON; -.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; FALSE_NEG.
BLOCKS Q6F7X1.
Genome annotation databases
GeneID 2880577; -.
GenomeReviews CR543861_GR; ACIAD3155.
KEGG aci:ACIAD3155; -.
NMPDR fig|62977.3.peg.2859; -.
Phylogenomic databases
HOGENOM Q6F7X1; -.
Genome annotation databases
CMR Q6F7X1; ACIAD3155.
Other
ProtoNet Q6F7X1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   328  328     Malate dehydrogenase. PRO_0000113343
NP_BIND   11    17  7     NAD (By similarity). 
NP_BIND   131   133  3     NAD (By similarity). 
ACT_SITE   189   189        Proton acceptor (By similarity). 
BINDING   94    94        Substrate (By similarity). 
BINDING   100   100        Substrate (By similarity). 
BINDING   107   107        NAD (By similarity). 
BINDING   114   114        NAD (By similarity). 
BINDING   133   133        Substrate (By similarity). 
BINDING   164   164        Substrate (By similarity). 
Sequence information
Length: 328 AA [This is the length of the unprocessed precursor] Molecular weight: 35449 Da [This is the MW of the unprocessed precursor] CRC64: 22AE35B28B08B5AB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKQPVRVAVT GAAGQIGYSL LFRIASGEML GKDQPVILQL LEIPVEKAQQ ALKGVMMELD 

        70         80         90        100        110        120 
DCAFPLLAGM IGTDDPKVAF KDADYALLVG SRPRGPGMER ADLLKVNGEI FIGQGQALNE 

       130        140        150        160        170        180 
VASRDVKVLV VGNPANTNAY IAMKSAPDLP AKNFTAMLRL DHNRALTQIA QKAGVAVADI 

       190        200        210        220        230        240 
EKLTVWGNHS PTMYADYRFA TANGENLKDK INDAEWNKDV FLPTVGKRGA AIIEARGLSS 

       250        260        270        280        290        300 
AASAANAAID HMRDWALGTN GKWVTMGIPS DGSYGIPEGV IYGVPVTCEN GEYKRVEGLE 

       310        320 
IDEFSRERMD KTLQELEEER AAIADMLK
Q6F7X1 in FASTA format

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