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UniProtKB/Swiss-Prot entry Q6CSH0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNL4_KLULA
Primary accession number Q6CSH0
Secondary accession numbers None
Integrated into Swiss-Prot on February 20, 2007
Sequence was last modified on August 16, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 25)
Name and origin of the protein
Protein name DNA ligase 4
Synonyms EC 6.5.1.1
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene name
Name: LIG4
OrderedLocusNames: KLLA0D01089g
From
Kluyveromyces lactis (Yeast) (Candida sphaerica) [TaxID: 28985] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR382124; CAH00215.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_453119.1; -.
3D structure databases
ModBase Q6CSH0.
Family and domain databases
InterPro IPR001357; BRCT.
IPR000977; DNA_ligase.
IPR012310; DNA_ligase_A_M.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF01068; DNA_ligase_A_M; 1.
Pfam graphical view of domain structure.
SMART SM00292; BRCT; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS50172; BRCT; 2.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q6CSH0.
Genome annotation databases
GeneID 2892937; -.
KEGG kla:KLLA0D01089g; -.
Phylogenomic databases
HOGENOM Q6CSH0; -.
Other
ProtoNet Q6CSH0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Nucleus; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   907  907     DNA ligase 4. PRO_0000278383
DOMAIN   655   754  100     BRCT 1. 
DOMAIN   800   906  107     BRCT 2. 
ACT_SITE   275   275        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 907 AA [This is the length of the unprocessed precursor] Molecular weight: 104634 Da [This is the MW of the unprocessed precursor] CRC64: 1CE0987C0B4ADFDE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNDCENFSPS PEFKWLCDEL LGKIYETSSK KHLIGKPVTV RYLEIITNFI KLWRSTVGNY 

        70         80         90        100        110        120 
IYPALRLIVP FRDRRIYNVK ENTLIKALCR YLRLPKSSET ENRLLRWKQR AARGVKLSDF 

       130        140        150        160        170        180 
CVEEIRKRQK DYEGANRITI DELNGYLDEV SQEGNGKRMG YMALTDSRAF NYCLNHMTFM 

       190        200        210        220        230        240 
EMKFFFDIIL KTRVLSGLEN MFLTAWHPDA TDYLSVVSDL DVLSQRLYNP NERLRQTDLS 

       250        260        270        280        290        300 
ITISHAFEPQ LAKRTHLSYE RVASKLQHDF IIEEKMDGER LQIHYINYGE QIKYLSRRGV 

       310        320        330        340        350        360 
DFSYLYGENS SSGPISPSLK LHFNVKDCIL DGEMITYDTE KDIVLPFGLV KSSAMNQIQS 

       370        380        390        400        410        420 
ELAGIAPTES YKPLFVAFDL VYLNGKSLTN LALERRKDYL TKILTPVERS VEIIQYMKAI 

       430        440        450        460        470        480 
NAEAIKDSLE QAISMGSEGI VLKHLHSKYF VGSRNTDWIK IKPEYLEQFG ENMDLLIIGR 

       490        500        510        520        530        540 
EQGKKDSFFC GLSISDPNEV AEKPRFISFC TIANGLSNEE FKDIERKTWG KWHIFSEDPP 

       550        560        570        580        590        600 
SPNLLGFGTK VPYEWIHPED SVVLEVKARA IDTKESEKRK YRSGCTLHFG YCKQIRYDKD 

       610        620        630        640        650        660 
WKTVASFSEF EDMKDARNFY NKRKSHQVTD GKKRASKRAK IGIVNSSEPT ALVAPVSNTF 

       670        680        690        700        710        720 
SNCRFRVISD YFDSTKRRRI SQEDLCSVIL EHGGEIVYTS DENNLPQDNL YIIGEKLTRE 

       730        740        750        760        770        780 
CKILLNAKNL IIRPSWIFSC IEEGYKTPFT ESDIFRGELE SSMDCSQFYT DFNTASLNHL 

       790        800        810        820        830        840 
LETANRGIKN PDSDLLLPEV PLFLFSNLKL AVLNSENVLD TSILEVEFAI KCHGGELVHI 

       850        860        870        880        890        900 
ENASIIIVFN DFISREDLFS LRQKIASKAV KESTESTPRI PRMVDISWAL DSIKDNYIAE 


TEHYQCL 

Q6CSH0 in FASTA format

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