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UniProtKB/Swiss-Prot entry Q6AS41

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_DESPS
Primary accession number Q6AS41
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on September 13, 2004 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 25)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: DP0105
From
Desulfotalea psychrophila [TaxID: 84980] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales; Desulfobulbaceae; Desulfotalea.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=LSv54 / DSM 12343;
DOI=10.1111/j.1462-2920.2004.00665.x; PubMed=15305914 [NCBI, ExPASy, EBI, Israel, Japan]
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.;
"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments.";
Environ. Microbiol. 6:887-902(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR522870; CAG34834.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_063841.1; -.
3D structure databases
ModBase Q6AS41.
Enzyme and pathway databases
BioCyc DPSY177439:DP0105-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q6AS41.
Genome annotation databases
GeneID 2945698; -.
GenomeReviews CR522870_GR; DP0105.
KEGG dps:DP0105; -.
NMPDR fig|177439.1.peg.105; -.
Phylogenomic databases
HOGENOM Q6AS41; -.
Genome annotation databases
CMR Q6AS41; DP0105.
Other
ProtoNet Q6AS41.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   421  421     Dihydroorotase. PRO_1000024081
METAL   59    59        Zinc 1 (By similarity). 
METAL   61    61        Zinc 1 (By similarity). 
METAL   140   140        Zinc 1; via carbamate group (By similarity). 
METAL   140   140        Zinc 2; via carbamate group (By similarity). 
METAL   177   177        Zinc 2 (By similarity). 
METAL   230   230        Zinc 2 (By similarity). 
METAL   303   303        Zinc 1 (By similarity). 
MOD_RES   140   140        N6-carboxylysine (By similarity). 
Sequence information
Length: 421 AA [This is the length of the unprocessed precursor] Molecular weight: 44919 Da [This is the MW of the unprocessed precursor] CRC64: A7319DA9FABAF02D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIIILKGGRV IDPRNRRDED ADIWMEDGQI IAPQETVPED AKIYDLAGKW VVPGLIDMHV 

        70         80         90        100        110        120 
HLRDPGEEYK ESIVTGTDAA AAGGFTAVAC MPNTDPVNDT GSVTRYILEK SEGAAARVYP 

       130        140        150        160        170        180 
VGALSEGLKG ESLAEYADMK HAGAVALTDD GNPVVSSQLM RRAMEYAKSH DMLVISHSEE 

       190        200        210        220        230        240 
PTLSKRGCMN EGLVATRLGL KGIPAVAESI MVQREIALAG LTGARLHIAH VSCIESLAAI 

       250        260        270        280        290        300 
RDAKKRGLPV TAETAPHYFS LTDDAVIGYD THAKMNPPLR TEEHRQAIRQ ALADGTLDVI 

       310        320        330        340        350        360 
ATDHAPHSIV EKEVTFEYAA NGIVGLETSL GLSLALVRDG VLTPSRLVEL MSSVPAQILS 

       370        380        390        400        410        420 
VAGGELGVGA IADVTVIDPE LEHTFLIAEG RSRGANSPFD GWKLKGAATL TFVAGEESYC 


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Q6AS41 in FASTA format

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