NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KPA171202 / DSM 16379;
DOI=10.1126/science.1100330; PubMed=15286373 [NCBI, ExPASy, EBI, Israel, Japan]
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.;
"The complete genome sequence of Propionibacterium acnes, a commensal of human skin.";
Science 305:671-673(2004).

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE017283; AAT83385.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_056343.1; -.

3D structure databases

ModBase

Q6A780.

Enzyme and pathway databases

BioCyc

PACN267747:PPA1650-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00594; polc; 1.

BLOCKS

Q6A780.

Genome annotation databases

GeneID

2931181; -.

GenomeReviews

AE017283_GR; PPA1650.

KEGG

pac:PPA1650; -.

NMPDR

fig|267747.1.peg.1620; -.

Phylogenomic databases

HOGENOM

Q6A780; -.

Genome annotation databases

CMR

Q6A780; PPA1650.

Other

ProtoNet

Q6A780.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1134`	`1134`		`Error-prone DNA polymerase.`	`PRO_0000103387`

Sequence information

Length: 1134 AA [This is the length of the unprocessed precursor]

Molecular weight: 124661 Da [This is the MW of the unprocessed precursor]

CRC64: 8D2F6F71B5B6D5B3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSYHNPPIPW RELEGRISGR PAPHGHQESH ADQVGYRHVR KPFDRHPVRP EGPVVPYAEL 

        70         80         90        100        110        120 
HCHSSYSFLD GASNPEDLVI RAVELGLSGL ALTDHDGLYG VVRMAEAAEA CGLSTIIGSE 

       130        140        150        160        170        180 
LSIGVPEPQN GVADPVGSHL LVLANGPEGY RRLAEALTDA YLVEGGRKGR PVHDLDHLAE 

       190        200        210        220        230        240 
VADGHWTVLT GCRKGAVRQG LVKGMLQAEA ELRRLVDLFG IDNVLVELTD HRAPTDSRDN 

       250        260        270        280        290        300 
DLLAELASRH SLLTVATTAA HYAGAEQFEL ACALSAVRAR RSLDEMDGWL PPGPVARLRS 

       310        320        330        340        350        360 
GAEMADLFSR HRDAVDNTVA VAERTAFHLK SVRPRLPDQK VPDGHTPISW LRHLVEEGRR 

       370        380        390        400        410        420 
ACYGDDPVAK DRLATELDLI EDRGFAGYFL IVSDIVEFAQ SQGILCQGRG SAAASAVCYV 

       430        440        450        460        470        480 
LGITVVDPVF YGLPFERFLS VLREEEPDID VDFDARRREE VIQYVYAKYG RRNAAQVADV 

       490        500        510        520        530        540 
ITYRPRSAVR DMAKALGYSQ GQQDAWSRQM ERRSVPPLPH DPDGPEIPDD VTTLAQQVMG 

       550        560        570        580        590        600 
LPRHLGIHSA GMVLTREPVG RICPIEPARM FGRTVLQWDK EDCAWMGLVK FDLLGLGMLS 

       610        620        630        640        650        660 
ALSISFDLIS QHCGRFWTLA SIPRNEPGVY DMLCRGDSIG VFQVESRAQI GALPRLKPRC 

       670        680        690        700        710        720 
FYDLAVEIGL IRPGPVQGGA VHPYIRRRTG VEPVTYPHPL LEPVLERTLG IPLFQEQLMQ 

       730        740        750        760        770        780 
MATTVGNCTA ADADLLRRAM GSKRGVERID SLRTKLFEGM AANGIDDDTA QGIYARIESF 

       790        800        810        820        830        840 
ANFGFAESHA LSFAGLVYTS AWIKLHYPAV FLAALLRSQP MGFYSSATLV ADARRHGVVT 

       850        860        870        880        890        900 
RRPDVARSSV GADLELLDAC CEELGSEELE TGIDECLHDH DESEIGAFDP NRDDGDHRRD 

       910        920        930        940        950        960 
THFAVRLGLS DVSGINIETA TRIVEERERE SFASLDDLAR RVDLSGEEVE ALALAGAFDD 

       970        980        990       1000       1010       1020 
LVGSRRGALW QIGQINGVAP GQLDVQVVTQ PPLLPEPTQM ELLGDDLRAT GISTADHPVR 

      1030       1040       1050       1060       1070       1080 
QVRDALNRRG VVQVDRLDGV ETRRRIEVAG VVTHRQRPGT AGGVTFLNLE DETGLLNVIV 

      1090       1100       1110       1120       1130 
TPGAWRHYRR VARTSRALVV RGILERGDEG VMSLQADRLE ALDLSVPTKS RDFR

Q6A780 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools