[1]	NUCLEOTIDE SEQUENCE. PubMed=6313961 [NCBI, ExPASy, EBI, Israel, Japan] Costa R.H., Draper K.G., Banks L., Powell K.L., Cohen G., Eisenberg R., Wagner E.K.; "High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein."; J. Virol. 48:591-603(1983).
[2]	NUCLEOTIDE SEQUENCE. PubMed=3005609 [NCBI, ExPASy, EBI, Israel, Japan] Draper K.G., Devi-Rao G., Costa R.H., Blair E.D., Thompson R.L., Wagner E.K.; "Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins."; J. Virol. 57:1023-1036(1986).
[3]	NUCLEOTIDE SEQUENCE. STRAIN=HF; DOI=10.1016/j.micinf.2006.10.019; PubMed=17218138 [NCBI, ExPASy, EBI, Israel, Japan] Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.; "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."; Microbes Infect. 9:142-149(2007).

Comments

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

K02022; AAA45771.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ889502; ABI63474.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q68978.

Ontologies

GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from InterPro).
GO:0004527;	Molecular function: exonuclease activity (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR001616; Herpes_alk_exo.
Graphical view of domain structure.

Pfam

PF01771; Herpes_alk_exo; 1.
Pfam graphical view of domain structure.

PRINTS

PR00924; ALKEXNUCLASE.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Exonuclease.

Features

None

Sequence information

Length: 626 AA

Molecular weight: 67470 Da

CRC64: A651D03A29C70260 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MESTGGPACP PGRTVTKRSW ALAEDTPRGP DSPPKRPRPN SLPLTTTFRP LPPPPQTTSA 

        70         80         90        100        110        120 
VDPSSHSPVN PPRDQHATDT ADEKPRAASP ALSDASGPPT PDIPLSPGGT HARDPDADPD 

       130        140        150        160        170        180 
SPDLDSMWSA SVIPNALPSH ILAETFERHL RGLLRGVRAP LAIGPLWARL DYLCSLAVVL 

       190        200        210        220        230        240 
EEAGMVDRGL GRHLWRLTRR APPAAADAVA PRPLMGFYEA ATQNQADCQL WALLRRGLTT 

       250        260        270        280        290        300 
ASTLRWGPQG PCFSPQWLKH NASLRPDVQS SAVMFGRVNE PTARSLLFRY CVGRADDGGE 

       310        320        330        340        350        360 
AGADTRRFIF HEPSDLAEEN VHTCGVLMDG HTGMVGASLD ILVCPRDIHG YLAPVPKTPL 

       370        380        390        400        410        420 
AFYEVKCRAK YAFDPMDPSD PTASAYEDLM AHRSPEAFRA FIRSIPKPSV RYFAPGRVPG 

       430        440        450        460        470        480 
PEEALVTQDQ AWSEAHASGE KRRCSAADRA LVELNSGVVS EVLLFGAPDL GRHTISPVSW 

       490        500        510        520        530        540 
SSGDLVRREP VFANPRHPNF KQILVQGYVL DSHFPDCPPH PHLVTFIGRH RTSAEEGVTF 

       550        560        570        580        590        600 
RLEDGAGALG AAGPSKASIL PNQAVPIALI ITPVRIDPEI YKAIQRSSRL AFDDTLAELW 

       610        620 
ASRSPGPGPA AAETTSSSPT TGRSSR

Q68978 in FASTA format

View entry in raw text format (no links)
Request for annotation of this UniProtKB/TrEMBL entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools