NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=T / IAM 14863;
DOI=10.1093/nar/gkh830; PubMed=15383646 [NCBI, ExPASy, EBI, Israel, Japan]
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.;
"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.";
Nucleic Acids Res. 32:4937-4944(2004).

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP006840; BAD40870.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_075714.1; -.

3D structure databases

ModBase

Q67N73.

Enzyme and pathway databases

BioCyc

STHE292459:STH1885-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00594; polc; 1.

BLOCKS

Q67N73.

Genome annotation databases

GeneID

2980226; -.

GenomeReviews

AP006840_GR; STH1885.

KEGG

sth:STH1885; -.

NMPDR

fig|292459.1.peg.1819; -.

Phylogenomic databases

HOGENOM

Q67N73; -.

Genome annotation databases

CMR

Q67N73; STH1885.

Other

ProtoNet

Q67N73.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1085`	`1085`		`Error-prone DNA polymerase.`	`PRO_0000103400`

Sequence information

Length: 1085 AA [This is the length of the unprocessed precursor]

Molecular weight: 120631 Da [This is the MW of the unprocessed precursor]

CRC64: 1BC11470BF0DB77E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSFVHLHVHS PFSFLDGASR LDDLIAEAAL HGMPALALTD HNNVSGAVRF QRKAQEAGIQ 

        70         80         90        100        110        120 
PIQGAELTLE GGYHLTLLAT GPKGYANLNR LITAAHLGQE PRATPGAMFA LAPGHDRLQP 

       130        140        150        160        170        180 
ACPLSALSHD TDGLIALSGC RRGEIPSLIL RGRLAEAEAA ARRYAAWFPG RFYLELHDER 

       190        200        210        220        230        240 
LPGEQALNRA LRDLGEALGL PLVVTSNVHH RTREEFFVHD LLTCVRTLTR IDQPHPERPL 

       250        260        270        280        290        300 
NDQRYLKPPE VMIERFREFP EAVKNTLAIA ERCRPVLDLD ARLHPEFQTP DGSHPAAYLT 

       310        320        330        340        350        360 
HLVYDGAARR YGRITERIRR RLEHELTIIT RLGYEDYFLL VWDVVRFARE RGIRCAGRGS 

       370        380        390        400        410        420 
AADSAVAYCL FITDVDAIER GLLFERFMSL ERAQKPDIDI DFDARRRDEV AAYVYRKYGA 

       430        440        450        460        470        480 
DHVASVCTYN TFQARSAVRD LGKAMGFQEA DLDYLAKRIP WHAGADEILT VMARYPELRQ 

       490        500        510        520        530        540 
SGIPWHKFEQ LVQAAERVAR FPRFIGTHLG GLVISRRPLL EVTPLQMAAK GQVVCQFDKE 

       550        560        570        580        590        600 
YVEDLGLVKL DLLSLRTFTA VDDAVRAIGD IDYEQIPHGD AATYEMLGVG ESIGVFQLES 

       610        620        630        640        650        660 
PAQRALQARL KPDRFEDIVA SVAIIRPGPI KGNMVEPFLA RRHGKEEVTY LHPKLKPILE 

       670        680        690        700        710        720 
KTYGVVLFQE QVIEIATAVA GFTPGEADQL RRVMTHARNR EDMEAIGRLF RQKAAAAGVD 

       730        740        750        760        770        780 
PAVADTIFSY IQGYASYGFC EAHAAAFANT AYKTAYLVRH YPAEYFAALM SAQPMGYYPI 

       790        800        810        820        830        840 
NTLAVEARRR GVGLLPVDIN RSEEAFTVEE WSREAWEAFW GMEPFAPEYP ATGKAIRIGL 

       850        860        870        880        890        900 
RAVKGVGEPA AAAILAARDG GEFRSLADLV RRTGGAVPRG PLEALVLAGA FDRLHSNRRA 

       910        920        930        940        950        960 
ALWQVAHLLE AERIRQERGA GQAGLLDGDA PGLGAQAAEA LEAASPQGTP AIADFGAAER 

       970        980        990       1000       1010       1020 
YLKEYELTGL MVRTHFMRFV RERLAREGYL TAQEVRQRRA GELVKVAGLP VCPHRPPTRS 

      1030       1040       1050       1060       1070       1080 
GKIVVFLSLE DETGLIDLTI FEDVYQRYGH LIFTDPRPPL AALGRVDRRG GHVSITVNRL 


RLLDT

Q67N73 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools