[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=FP-9 / Isolate HP-438; PubMed=8077953 [NCBI, ExPASy, EBI, Israel, Japan] Skinner M.A., Moore J.B., Binns M.M., Smith G.L., Boursnell M.E.G.; "Deletion of fowlpox virus homologues of vaccinia virus genes between the 3 beta-hydroxysteroid dehydrogenase (A44L) and DNA ligase (A50R) genes."; J. Gen. Virol. 75:2495-2498(1994).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1128/JVI.74.8.3815-3831.2000; PubMed=10729156 [NCBI, ExPASy, EBI, Israel, Japan] Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.; "The genome of fowlpox virus."; J. Virol. 74:3815-3831(2000).

Comments

FUNCTION: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA. It is not essential for viral replication and recombination.
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z29716; CAA82805.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF198100; AAF44387.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S41974; S41974.

RefSeq

NP_039006.1; -.

3D structure databases

ModBase

Q67480.

Family and domain databases

InterPro

IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.50.140; OB_NA_bd_sub; 1.

Pfam

PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00574; dnl1; 1.

PROSITE

PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; FALSE_NEG.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q67480.

Genome annotation databases

GeneID

1486591; -.

Other

ProtoNet

Q67480.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cell cycle; Cell division; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 564`	`564`	`DNA ligase.`	`PRO_0000059591`
`ACT_SITE`	`236 236`		`N6-AMP-lysine intermediate (By similarity).`
`CONFLICT`	`281 281`		`K -> N (in Ref. 1; CAA82805).`

Sequence information

Length: 564 AA [This is the length of the unprocessed precursor]

Molecular weight: 64487 Da [This is the MW of the unprocessed precursor]

CRC64: 85B5D829FEE89FA0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEVTLKEFRE LCTSISTESS YVKKTKLISE FIHRGRDYND VYIITKLLLP GTGKLIYNIN 

        70         80         90        100        110        120 
DKQLVKLFSK IFCHDADEMY KYVINIGDVA YVIGSFLKKS KSVVDYATES TLTLHEVDCF 

       130        140        150        160        170        180 
LTRLSTVTRE NDQIKEIKKI IPRCTPNDLR HIIRLIKHDL RMNIGPKHVL SGLHKDAYGI 

       190        200        210        220        230        240 
FKLCNNLEQV VQRSLEDNIK PLIELMVPLQ PMLASACKTF SEAVKKCPNG IIVEFKYDGE 

       250        260        270        280        290        300 
RIQIHKHDKN FKYFSRSLKP ITPHKVTDFE ELLDRAFPSA KNMILDGEII LIDTETNQPL 

       310        320        330        340        350        360 
PFGTLGINKK SMYHNACVCI FIFDCLYFND TVLIDKPLIE RRNIIHANIK EIPNRILLSE 

       370        380        390        400        410        420 
VKNISTDEEL SKLLHIVLSK NIEGFVLKDA KGVYEPGMRR WLKIKKDYLD GCVMADKADL 

       430        440        450        460        470        480 
VVLGAYYGKG NKSGILSSFL MGCYDTKSEK WCTVTKCSGG HTDLELQEIN DNLSVVPFDR 

       490        500        510        520        530        540 
NAIPDWLSIN KIHYPDVIIS DISLAPVWEI IGSEFTRSST HTASNISIRF PRCSRIREDK 

       550        560 
TYETANNLND IKQLYAVSIS PPEE

Q67480 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools