[1]	NUCLEOTIDE SEQUENCE [MRNA]. Song J.H., Wise T.H., Ford J.J.; "Complete sequence of activin receptor IIB cDNA in boars."; Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (By similarity).
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY705387; AAU07920.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001005350.1; -.

UniGene

Ssc.42773

3D structure databases

SMR

Q66T47; 24-117.

ModBase

Q66T47.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR015768; Activin_II_recpt_C.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.

PANTHER

PTHR23255:SF10; Activin_II_recpt_C; 1.

Pfam

PF01064; Activin_recp; 1.
Pfam graphical view of domain structure.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q66T47.

Genome annotation databases

GeneID

448845; -.

KEGG

ssc:448845; -.

Phylogenomic databases

HOVERGEN

Q66T47; -.

Other

ProtoNet

Q66T47.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`	`Potential.`
`CHAIN`	`19 512`	`494`	`Activin receptor type-2B.`	`PRO_0000234419`
`TOPO_DOM`	`19 137`	`119`	`Extracellular (Potential).`
`TRANSMEM`	`138 158`	`21`	`Potential.`
`TOPO_DOM`	`159 512`	`354`	`Cytoplasmic (Potential).`
`DOMAIN`	`190 480`	`291`	`Protein kinase.`
`NP_BIND`	`196 204`	`9`	`ATP (By similarity).`
`ACT_SITE`	`321 321`		`Proton acceptor (By similarity).`
`BINDING`	`217 217`		`ATP (By similarity).`
`CARBOHYD`	`42 42`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`65 65`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`29 59`		`By similarity.`
`DISULFID`	`49 77`		`By similarity.`
`DISULFID`	`84 103`		`By similarity.`
`DISULFID`	`90 102`		`By similarity.`
`DISULFID`	`104 109`		`By similarity.`

Sequence information

Length: 512 AA [This is the length of the unprocessed precursor]

Molecular weight: 57693 Da [This is the MW of the unprocessed precursor]

CRC64: 59A5A00239A92EAC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTAPWAALAL LWGSLCVGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 

        70         80         90        100        110        120 
ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 

       130        140        150        160        170        180 
GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP 

       190        200        210        220        230        240 
PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 

       250        260        270        280        290        300 
HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 

       310        320        330        340        350        360 
LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 

       370        380        390        400        410        420 
TRRYMAPEVL EGAINFQRNA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 

       430        440        450        460        470        480 
HPSLEELQEV VVHKKMRPAI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 

       490        500        510 
IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI

Q66T47 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools