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UniProtKB/Swiss-Prot entry Q64446

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATP7B_MOUSE
Primary accession number Q64446
Secondary accession numbers None
Integrated into Swiss-Prot on December 8, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 79)
Name and origin of the protein
Protein name Copper-transporting ATPase 2
Synonyms EC 3.6.3.4
Copper pump 2
Wilson disease-associated protein homolog
Gene name
Name: Atp7b
Synonyms: Wnd
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=DAT;
TISSUE=Liver;
DOI=10.1093/hmg/5.10.1619; PubMed=8894697 [NCBI, ExPASy, EBI, Israel, Japan]
Theophilos M.B., Cox D.W., Mercer J.F.B.;
"The toxic milk mouse is a murine model of Wilson disease.";
Hum. Mol. Genet. 5:1619-1624(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U38477; AAC52852.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.87854
3D structure databases
HSSP Q04656; 1AW0. [HSSP ENTRY / PDB]
SMR Q64446; 488-635, 1036-1193.
ModBase Q64446.
PTM databases
PhosphoSite Q64446; -.
Organism-specific databases
MGI MGI:103297; Atp7b.
Gene expression databases
ArrayExpress Q64446; -.
CleanEx MM_ATP7B; -.
GermOnline ENSMUSG00000006567; Mus musculus.
Ontologies
GO
GO:0005770; Cellular component: late endosome (inferred from sequence or structural similarity from UniProtKB).
GO:0005624; Cellular component: membrane fraction (inferred from direct assay from MGI).
GO:0005802; Cellular component: trans-Golgi network (inferred from direct assay from MGI).
GO:0005524; Molecular function: ATP binding (inferred from sequence or structural similarity from HGNC).
GO:0005507; Molecular function: copper ion binding (inferred from sequence or structural similarity from HGNC).
GO:0004008; Molecular function: copper-exporting ATPase activity (inferred from direct assay from MGI).
GO:0006878; Biological process: cellular copper ion homeostasis (inferred from mutant phenotype from MGI).
GO:0006882; Biological process: cellular zinc ion homeostasis (inferred from mutant phenotype from MGI).
GO:0015680; Biological process: intracellular copper ion transport (inferred from mutant phenotype from MGI).
GO:0007595; Biological process: lactation (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR006416; ATPase-IB_hvy.
IPR001757; ATPase_P.
IPR006403; ATPase_P_cat/Cu.
IPR001877; Cu_ATPase1.
IPR006122; Cu_ion_bd.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR006121; HeavyMe_transpt.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00122; E1-E2_ATPase; 1.
PF00403; HMA; 6.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00942; CUATPASEI.
TIGRFAMs TIGR01511; ATPase-IB1_Cu; 1.
TIGR01525; ATPase-IB_hvy; 1.
TIGR01494; ATPase_P-type; 2.
TIGR00003; Cu_ion_bd; 2.
PROSITE PS00154; ATPASE_E1_E2; 1.
PS01047; HMA_1; 5.
PS50846; HMA_2; 6.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q64446.
Genome annotation databases
Ensembl ENSMUSG00000006567; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q64446; -.
HOVERGEN Q64446; -.
Other
SOURCE Atp7b; Mus musculus.
ProtoNet Q64446.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Copper; Copper transport; Disease mutation; Golgi apparatus; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1462  1462     Copper-transporting ATPase 2. PRO_0000046315
TOPO_DOM   1    655  655     Cytoplasmic (Potential). 
TRANSMEM   656    677  22     Potential. 
TOPO_DOM   678    699  22     Extracellular (Potential). 
TRANSMEM   700    719  20     Potential. 
TOPO_DOM   720    726  7     Cytoplasmic (Potential). 
TRANSMEM   727    747  21     Potential. 
TOPO_DOM   748    766  19     Extracellular (Potential). 
TRANSMEM   767    787  21     Potential. 
TOPO_DOM   788    921  134     Cytoplasmic (Potential). 
TRANSMEM   922    944  23     Potential. 
TOPO_DOM   945    974  30     Extracellular (Potential). 
TRANSMEM   975    996  22     Potential. 
TOPO_DOM   997   1319  323     Cytoplasmic (Potential). 
TRANSMEM   1320   1337  18     Potential. 
TOPO_DOM   1338   1348  11     Extracellular (Potential). 
TRANSMEM   1349   1368  20     Potential. 
TOPO_DOM   1369   1462  94     Cytoplasmic (Potential). 
DOMAIN   69    135  67     HMA 1. 
DOMAIN   154    220  67     HMA 2. 
DOMAIN   268    334  67     HMA 3. 
DOMAIN   362    428  67     HMA 4. 
DOMAIN   491    557  67     HMA 5. 
DOMAIN   567    633  67     HMA 6. 
ACT_SITE   1029   1029        4-aspartylphosphate intermediate (By similarity). 
METAL   1264   1264        Magnesium (By similarity). 
METAL   1268   1268        Magnesium (By similarity). 
VARIANT   1356   1356  1     M -> V (in tx mice). 
Sequence information
Length: 1462 AA [This is the length of the unprocessed precursor] Molecular weight: 157298 Da [This is the MW of the unprocessed precursor] CRC64: 67F5C659CE9A54CD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDPRKNLASV GTMPEQERQV TAKEASRKIL SKLALPGRPW EQSMKQSFAF DNVGYEGGLD 

        70         80         90        100        110        120 
STSSSPAATD VVNILGMTCH SCVKSIEDRI SSLKGIVNIK VSLEQGKHTV RYVPSVMNLQ 

       130        140        150        160        170        180 
QICLQIEDMG FEASAAEGKA ASWPSRSSPA QEAVVKLRVE GMTCQSCVSS IEGKIRKLQG 

       190        200        210        220        230        240 
VVRIKVSLSN QEAVITYQPY LIQPEDLRDH ICDMGFEAAI KNRTAPLRLG PIDVNKLEST 

       250        260        270        280        290        300 
NLKKETVSPV QISNHFETLG HQGSYLATLP LRIDGMHCKS CVLNIEGNIG QLPGVQNIHV 

       310        320        330        340        350        360 
SLENKTAQIQ YDPSCVTPMF LQTAIEALPP GHFKVSLPDG VEENEPQSGS SQRHQEQGPG 

       370        380        390        400        410        420 
RTAVLTISGI TCASSVQPIE DMLSQRKGVQ QTSISLAEGT GAVLYDPSIV SLDELRTAVE 

       430        440        450        460        470        480 
DMGFEVSVNS ETFTINPVRN FKSGNSVPQT MGDIAGSVQK MAPDTRGLPT HQGPGHSSET 

       490        500        510        520        530        540 
PSSPGATASQ KCFVQIKGMT CASCVSNIER SLQRHAGILS VLVALMSGKA EVKYDPEIIQ 

       550        560        570        580        590        600 
SPRIAQLIQD LGFEASVMED NTVSEGDIEL IITGMTCASC VHNIESKLTR TNGITYASVA 

       610        620        630        640        650        660 
LATSKAHVKF DPEIVGPRDI IKIIEEIGFH ASLAQRNPNA HHLDHKTEIK QWKKSFLCSL 

       670        680        690        700        710        720 
VFGIPVMGLM VYMLIPSSTP QETMVLDHNI IPGLSVLNLI FFILCTFVQF LGGWYFYVQA 

       730        740        750        760        770        780 
YKSLRHRSAN MDVLIVLATT IAYAYSLVIL VVAVAEKAEK SPVTFFDTPP MLFVFIALGR 

       790        800        810        820        830        840 
WLEHVAKSKT SEALAKLMSL QATEATVVTL GEDNLILREE QVPMELVQRG DVIKVVPGGK 

       850        860        870        880        890        900 
FPVDGKVLEG NTMADESLIT GEAMPVTKKP GSIVIAGSIN AHGSVLLKAT HVGNDTTLAQ 

       910        920        930        940        950        960 
IVKLVEEAQM SKAPIQQLAD RFSGYFVPFI IIISTLTLVV WIVIGFVDFG VVQKYFPSPS 

       970        980        990       1000       1010       1020 
KHISQTEVII RFAFQTSITV LCIACPCSLG LATPTAVMVG TGVAAQNGVL IKGGKPLEMA 

      1030       1040       1050       1060       1070       1080 
HKIKTVMFDK TGTITHGVPR VMRFLLLADV ATLPLRKVLA VVGTAEASSE HPLGVAVTKY 

      1090       1100       1110       1120       1130       1140 
CKEELGTETL GYSTDFQAVP GCGISCKVSN VEGILARSDL TAHPVGVGNP PTGEGAGPQT 

      1150       1160       1170       1180       1190       1200 
FSVLIGNREW MRRNGLTISS DISDAMTDHE MKGQTAILVA IDGVLCGMIA IADAVKPEAA 

      1210       1220       1230       1240       1250       1260 
LAIYTLKSMG VDVALITGDN RKTARAIATQ VGINKVFAEV LPSHKVAKVQ ELQNEGKKVA 

      1270       1280       1290       1300       1310       1320 
MVGDGVNDSP ALAQADVGIA IGTGTDVAIE AADVVLIRND LLDVVASIHL SKRTVRRIRV 

      1330       1340       1350       1360       1370       1380 
NLVLALIYNM VGIPIAAGVF MPIGIVLQPW MGSAAMAASS VSVVLSSLQL KCYRKPDLER 

      1390       1400       1410       1420       1430       1440 
YEAQAHGRMK PLSASQVSVH IGMDDRRRDS PRATAWDQVS YVSQVSLSSL TSDRLSRHGG 

      1450       1460 
AAEDGGDKWS LLLSDRDEEQ CI
Q64446 in FASTA format

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View entry in raw text format (no links)
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