ID AMHR2_RAT Reviewed; 557 AA. AC Q62893; Q63045; Q9R0A7; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 02-SEP-2008, entry version 75. DE RecName: Full=Anti-Muellerian hormone type-2 receptor; DE EC=2.7.11.30; DE AltName: Full=Anti-Muellerian hormone type II receptor; DE Short=AMH type II receptor; DE AltName: Full=MIS type II receptor; DE AltName: Full=MISRII; DE Short=MRII; DE AltName: Full=C14; DE Flags: Precursor; GN Name=Amhr2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=96107132; PubMed=8536608; DOI=10.1210/en.137.1.160; RA Teixeira J., He W.W., Shah P.C., Morikawa N., Lee M.M., Catlin E.A., RA Hudson P.L., Wing J., Maclaughlin D.T., Donahoe P.K.; RT "Developmental expression of a candidate Muellerian inhibiting RT substance type II receptor."; RL Endocrinology 137:160-165(1996). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RX MEDLINE=94163972; PubMed=8119126; RA Baarends W.M., Van Helmond M.J.L., Post M., Van der Schoot P.J.C.M., RA Hoogerbrugge J.W., de Winter J.P., Uilenbroek J.T.J., Karels B., RA Wilming L.G., Meijers J.H.C., Themmem A.P.N., Grootegoed A.J.; RT "A novel member of the transmembrane serine/threonine kinase receptor RT family is specifically expressed in the gonads and in mesenchymal RT cells adjacent to the Muellerian duct."; RL Development 120:189-197(1994). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16. RC STRAIN=Sprague-Dawley; RX MEDLINE=20040636; PubMed=10570158; DOI=10.1073/pnas.96.24.13831; RA Teixeira J., Kehas D.J., Antun R., Donahoe P.K.; RT "Transcriptional regulation of the rat Muellerian inhibiting substance RT type II receptor in rodent Leydig cells."; RL Proc. Natl. Acad. Sci. U.S.A. 96:13831-13838(1999). CC -!- FUNCTION: On ligand binding, forms a receptor complex consisting CC of two type II and two type I transmembrane serine/threonine CC kinases. Type II receptors phosphorylate and activate type I CC receptors which autophosphorylate, then bind and activate SMAD CC transcriptional regulators. Receptor for anti-Muellerian hormone. CC -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor- CC protein] phosphate. CC -!- COFACTOR: Magnesium or manganese (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- DEVELOPMENTAL STAGE: Expressed in the mesenchymal cells CC surrounding the Muellerian duct at embryonic days 14, 15, and 16 CC and in tubular and follicular structures of the fetal gonads. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr CC protein kinase family. TGFB receptor subfamily. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U42427; AAC52343.1; -; mRNA. DR EMBL; X71916; CAA50731.1; -; mRNA. DR EMBL; AF092445; AAC64138.1; -; Genomic_DNA. DR PIR; S41627; S41627. DR RefSeq; NP_112260.1; -. DR UniGene; Rn.10165; -. DR HSSP; P36897; 1IAS. DR Ensembl; ENSRNOG00000014850; Rattus norvegicus. DR GeneID; 29530; -. DR KEGG; rno:29530; -. DR RGD; 70964; Amhr2. DR HOVERGEN; Q62893; -. DR ArrayExpress; Q62893; -. DR GermOnline; ENSRNOG00000014850; Rattus norvegicus. DR GO; GO:0042562; F:hormone binding; ISS:UniProtKB. DR GO; GO:0004872; F:receptor activity; ISS:UniProtKB. DR GO; GO:0007548; P:sex differentiation; ISS:UniProtKB. DR GO; GO:0007165; P:signal transduction; ISS:UniProtKB. DR InterPro; IPR017193; Anti-muellerian_hrmn_rcpt_II. DR InterPro; IPR015771; Anti-muellerian_hrmn_rcpt_II_C. DR InterPro; IPR000719; Prot_kinase_core. DR InterPro; IPR017441; Protein_kinase_ATP_bd_CS. DR InterPro; IPR017442; Se/Thr_pkinase-rel. DR InterPro; IPR008271; Ser_thr_pkin_AS. DR PANTHER; PTHR23255:SF4; MIS_II_R; 1. DR Pfam; PF00069; Pkinase; 1. DR PIRSF; PIRSF037392; AMHRII; 1. DR ProDom; PD000001; Prot_kinase; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; FALSE_NEG. PE 2: Evidence at transcript level; KW ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; KW Metal-binding; Nucleotide-binding; Receptor; KW Serine/threonine-protein kinase; Signal; Transferase; Transmembrane. FT SIGNAL 1 17 Potential. FT CHAIN 18 557 Anti-Muellerian hormone type-2 receptor. FT /FTId=PRO_0000024409. FT TOPO_DOM 18 144 Extracellular (Potential). FT TRANSMEM 145 165 Potential. FT TOPO_DOM 166 557 Cytoplasmic (Potential). FT DOMAIN 201 511 Protein kinase. FT NP_BIND 207 215 ATP (By similarity). FT ACT_SITE 331 331 Proton acceptor (By similarity). FT BINDING 228 228 ATP (By similarity). FT CARBOHYD 66 66 N-linked (GlcNAc...) (Potential). FT CARBOHYD 119 119 N-linked (GlcNAc...) (Potential). FT CONFLICT 527 527 C -> Y (in Ref. 2; CAA50731). SQ SEQUENCE 557 AA; 59749 MW; 8EDEE9C0C32EBDD5 CRC64; MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP KGIRCLYSHC CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP SPSSTLFTCS CGTDFCNANY SHLPPSGNRG APGPQEPQAT PGGPIWMAQL LLGVFLVLLL SIIILALLQR KACRVQGGSD PEPEPGSGGD CSEELPELAE LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA ERAVYQLLGL QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL GLALVLPGLA QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG TALQRADVYS LALLLWEILS RCSDLRPDHR PPPFQLAYEA ELGSNPSACE LWALAVAERK RPNIPSSWSC SATDPRGLRE LLEDCWDADP EARLTAECVQ QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP QQSSCLLSVQ QGSGSKS //