[1]	NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING. TISSUE=Brain; DOI=10.1016/0014-5793(94)01156-7; PubMed=7957954 [NCBI, ExPASy, EBI, Israel, Japan] Suzuki A., Shioda N., Maeda T., Tada M., Ueno N.; "Cloning of an isoform of mouse TGF-beta type II receptor gene."; FEBS Lett. 355:19-22(1994).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=8119124 [NCBI, ExPASy, EBI, Israel, Japan] Lawler S., Candia A.F., Ebner R., Shum L., Lopez A.R., Moses H.L., Wright C.V., Derynck R.; "The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1."; Development 120:165-175(1994).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM RII-2). TISSUE=Olfactory epithelium; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBUNIT: Binds to DAXX. Interacts with TCTEX1D4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	RII-2
Isoform ID	Q62312-1
This is the isoform sequence displayed in this entry.

Name	RII-1
Isoform ID	Q62312-2
Features which should be applied to build the isoform sequence: VSP_004955, VSP_004956.

TISSUE SPECIFICITY: Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus.
PTM: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D32072; BAA06840.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S69114; AAB30100.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC052629; AAH52629.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S51371; S51371.

UniGene

Mm.172346

3D structure databases

HSSP

P37173; 1KTZ. [HSSP ENTRY / PDB]

Q62312; 64-184.

PTM databases

Q62312; -.

Organism-specific databases

MGI

MGI:98729; Tgfbr2.

GeneLynx

Tgfbr2; Mus musculus.

Gene expression databases

ArrayExpress

Q62312; -.

CleanEx

MM_TGFBR2; -.

GermOnline

ENSMUSG00000032440; Mus musculus.

Ontologies

GO:0009897;	Cellular component: external side of plasma membrane (inferred from direct assay from MGI).
GO:0032147;	Biological process: activation of protein kinase activity (inferred from direct assay from MGI).
GO:0048701;	Biological process: embryonic cranial skeleton morphogenesis (inferred from mutant phenotype from MGI).
GO:0007507;	Biological process: heart development (inferred from mutant phenotype from MGI).
GO:0043011;	Biological process: myeloid dendritic cell differentiation (inferred from mutant phenotype from MGI).
GO:0001569;	Biological process: patterning of blood vessels (inferred from mutant phenotype from MGI).
GO:0002663;	Biological process: positive regulation of B cell tolerance induction (inferred from mutant phenotype from MGI).
GO:0051138;	Biological process: positive regulation of NK T cell differentiation (inferred from mutant phenotype from MGI).
GO:0002666;	Biological process: positive regulation of T cell tolerance induction (inferred from mutant phenotype from MGI).
GO:0002651;	Biological process: positive regulation of tolerance induction to self antigen (inferred from mutant phenotype from MGI).
GO:0006468;	Biological process: protein amino acid phosphorylation (traceable author statement from MGI).
GO:0042127;	Biological process: regulation of cell proliferation (inferred from mutant phenotype from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR008271; Ser_thr_pkin_AS.
IPR015769; TGF-beta_II_C.
IPR015013; TGF_beta_receptor2.
IPR017194; TGFRII.
Graphical view of domain structure.

PANTHER

PTHR23255:SF11; TGF-beta_II_C; 1.

Pfam

PF08917; ecTbetaR2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF037393; TGFRII; 1.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q62312.

Genome annotation databases

Ensembl

ENSMUSG00000032440; Mus musculus. [Contig view]

Phylogenomic databases

HOGENOM

Q62312; -.

HOVERGEN

Q62312; -.

Other

SOURCE

Tgfbr2; Mus musculus.

ProtoNet

Q62312.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`	`Potential.`
`CHAIN`	`24 592`	`569`	`TGF-beta receptor type-2.`	`PRO_0000024427`
`TOPO_DOM`	`24 184`	`161`	`Extracellular (Potential).`
`TRANSMEM`	`185 214`	`30`	`Potential.`
`TOPO_DOM`	`215 592`	`378`	`Cytoplasmic (Potential).`
`DOMAIN`	`269 569`	`301`	`Protein kinase.`
`NP_BIND`	`275 283`	`9`	`ATP (By similarity).`
`ACT_SITE`	`404 404`		`Proton acceptor (By similarity).`
`BINDING`	`302 302`		`ATP (By similarity).`
`MOD_RES`	`573 573`		`Phosphoserine (By similarity).`
`CARBOHYD`	`48 48`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`95 95`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`119 119`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`76 109`		`By similarity.`
`DISULFID`	`79 96`		`By similarity.`
`DISULFID`	`86 92`		`By similarity.`
`DISULFID`	`102 126`		`By similarity.`
`DISULFID`	`146 161`		`By similarity.`
`DISULFID`	`163 168`		`By similarity.`
`VAR_SEQ`	`32 56`		`Missing (in isoform RII-1).`	`VSP_004955`
`VAR_SEQ`	`57 57`		`F -> V (in isoform RII-1).`	`VSP_004956`
`CONFLICT`	`8 8`		`G -> A (in Ref. 2; AAB30100).`
`CONFLICT`	`117 117`		`D -> N (in Ref. 2; AAB30100).`
`CONFLICT`	`354 354`		`A -> R (in Ref. 2; AAB30100).`
`CONFLICT`	`440 443`		`NSGQ -> KQRE (in Ref. 2; AAB30100).`
`CONFLICT`	`486 486`		`C -> W (in Ref. 2; AAB30100).`
`CONFLICT`	`506 506`		`H -> P (in Ref. 2; AAB30100).`
`CONFLICT`	`569 570`		`PE -> MD (in Ref. 2; AAB30100).`

Sequence information

Length: 592 AA [This is the length of the unprocessed precursor]

Molecular weight: 67122 Da [This is the MW of the unprocessed precursor]

CRC64: 1A12D58550921F5E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SDVEMEAQKD ASIHLSCNRT IHPLKHFNSD 

        70         80         90        100        110        120 
VMASDNGGAV KLPQLCKFCD VRLSTCDNQK SCMSNCSITA ICEKPHEVCV AVWRKNDKNI 

       130        140        150        160        170        180 
TLETVCHDPK LTYHGFTLED AASPKCVMKE KKRAGETFFM CACNMEECND YIIFSEEYTT 

       190        200        210        220        230        240 
SSPDLLLVII QVTGVSLLPP LGIAIAVIII FYCYRVHRQQ KLSPSWESSK PRKLMDFSDN 

       250        260        270        280        290        300 
CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 

       310        320        330        340        350        360 
VKIFPYEEYS SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE 

       370        380        390        400        410        420 
YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL 

       430        440        450        460        470        480 
CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW 

       490        500        510        520        530        540 
EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDSVLRDR GRPEIPSFWL NHQGIQIVCE 

       550        560        570        580        590 
TLTECWDHDP EARLTAQCVA ERFSELEHPE RLSGRSCSQE KIPEDGSLNT TK

Q62312 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools