[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
TISSUE=Embryo;
DOI=10.1016/0092-8674(93)90627-3; PubMed=7916661 [NCBI, ExPASy, EBI, Israel, Japan]
Echelard Y.,
Epstein D.J.,
St Jacques B.,
Shen L.,
Mohler J.,
McMahon J.A.,
McMahon A.P.;
"Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.";
Cell 75:1417-1430(1993).
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[2]
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SEQUENCE REVISION TO 122.
McMahon A.P.;
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], AND AUTOPROTEOLYTIC CLEAVAGE.
PubMed=7720571 [NCBI, ExPASy, EBI, Israel, Japan]
Chang D.T.,
Lopez A.,
von Kessler D.P.,
Chiang C.,
Simandl B.K.,
Zhao R.,
Seldin M.F.,
Fallon J.F.,
Beachy P.A.;
"Products, genetic linkage and limb patterning activity of a murine hedgehog gene.";
Development 120:3339-3353(1994).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P.,
Kasukawa T.,
Katayama S.,
Gough J.,
Frith M.C.,
Maeda N.,
Oyama R.,
Ravasi T.,
Lenhard B.,
Wells C.,
Kodzius R.,
Shimokawa K.,
Bajic V.B.,
Brenner S.E.,
Batalov S.,
Forrest A.R.,
Zavolan M.,
Davis M.J.,
Wilming L.G., ![]()
Aidinis V.,
Allen J.E.,
Ambesi-Impiombato A.,
Apweiler R.,
Aturaliya R.N.,
Bailey T.L.,
Bansal M.,
Baxter L.,
Beisel K.W.,
Bersano T.,
Bono H.,
Chalk A.M.,
Chiu K.P.,
Choudhary V.,
Christoffels A.,
Clutterbuck D.R.,
Crowe M.L.,
Dalla E.,
Dalrymple B.P.,
de Bono B.,
Della Gatta G.,
di Bernardo D.,
Down T.,
Engstrom P.,
Fagiolini M.,
Faulkner G.,
Fletcher C.F.,
Fukushima T.,
Furuno M.,
Futaki S.,
Gariboldi M.,
Georgii-Hemming P.,
Gingeras T.R.,
Gojobori T.,
Green R.E.,
Gustincich S.,
Harbers M.,
Hayashi Y.,
Hensch T.K.,
Hirokawa N.,
Hill D.,
Huminiecki L.,
Iacono M.,
Ikeo K.,
Iwama A.,
Ishikawa T.,
Jakt M.,
Kanapin A.,
Katoh M.,
Kawasawa Y.,
Kelso J.,
Kitamura H.,
Kitano H.,
Kollias G.,
Krishnan S.P.,
Kruger A.,
Kummerfeld S.K.,
Kurochkin I.V.,
Lareau L.F.,
Lazarevic D.,
Lipovich L.,
Liu J.,
Liuni S.,
McWilliam S.,
Madan Babu M.,
Madera M.,
Marchionni L.,
Matsuda H.,
Matsuzawa S.,
Miki H.,
Mignone F.,
Miyake S.,
Morris K.,
Mottagui-Tabar S.,
Mulder N.,
Nakano N.,
Nakauchi H.,
Ng P.,
Nilsson R.,
Nishiguchi S.,
Nishikawa S.,
Nori F.,
Ohara O.,
Okazaki Y.,
Orlando V.,
Pang K.C.,
Pavan W.J.,
Pavesi G.,
Pesole G.,
Petrovsky N.,
Piazza S.,
Reed J.,
Reid J.F.,
Ring B.Z.,
Ringwald M.,
Rost B.,
Ruan Y.,
Salzberg S.L.,
Sandelin A.,
Schneider C.,
Schoenbach C.,
Sekiguchi K.,
Semple C.A.,
Seno S.,
Sessa L.,
Sheng Y.,
Shibata Y.,
Shimada H.,
Shimada K.,
Silva D.,
Sinclair B.,
Sperling S.,
Stupka E.,
Sugiura K.,
Sultana R.,
Takenaka Y.,
Taki K.,
Tammoja K.,
Tan S.L.,
Tang S.,
Taylor M.S.,
Tegner J.,
Teichmann S.A.,
Ueda H.R.,
van Nimwegen E.,
Verardo R.,
Wei C.L.,
Yagi K.,
Yamanishi H.,
Zabarovsky E.,
Zhu S.,
Zimmer A.,
Hide W.,
Bult C.,
Grimmond S.M.,
Teasdale R.D.,
Liu E.T.,
Brusic V.,
Quackenbush J.,
Wahlestedt C.,
Mattick J.S.,
Hume D.A.,
Kai C.,
Sasaki D.,
Tomaru Y.,
Fukuda S.,
Kanamori-Katayama M.,
Suzuki M.,
Aoki J.,
Arakawa T.,
Iida J.,
Imamura K.,
Itoh M.,
Kato T.,
Kawaji H.,
Kawagashira N.,
Kawashima T.,
Kojima M.,
Kondo S.,
Konno H.,
Nakano K.,
Ninomiya N.,
Nishio T.,
Okada M.,
Plessy C.,
Shibata K.,
Shiraki T.,
Suzuki S.,
Tagami M.,
Waki K.,
Watahiki A.,
Okamura-Oho Y.,
Suzuki H.,
Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Limb;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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FUNCTION, AND AUTOPROTEOLYTIC CLEAVAGE.
DOI=10.1016/0092-8674(95)90397-6; PubMed=7736596 [NCBI, ExPASy, EBI, Israel, Japan]
Roelink H.,
Porter J.A.,
Chiang C.,
Tanabe Y.,
Chang D.T.,
Beachy P.A.,
Jessell T.M.;
"Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis.";
Cell 81:445-455(1995).
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[7]
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CHOLESTERYLATION AT GLY-198.
DOI=10.1126/science.274.5285.255; PubMed=8824192 [NCBI, ExPASy, EBI, Israel, Japan]
Porter J.A.,
Young K.E.,
Beachy P.A.;
"Cholesterol modification of hedgehog signaling proteins in animal development.";
Science 274:255-259(1996).
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[8]
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PALMITOYLATION AT CYS-25, AND MUTAGENESIS OF CYS-25.
DOI=10.1126/science.1064437; PubMed=11486055 [NCBI, ExPASy, EBI, Israel, Japan]
Chamoun Z.,
Mann R.K.,
Nellen D.,
von Kessler D.P.,
Bellotto M.,
Beachy P.A.,
Basler K.;
"Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.";
Science 293:2080-2084(2001).
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[9]
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PALMITOYLATION AT CYS-25, MUTAGENESIS OF CYS-25, SUBUNIT, AND SUBCELLULAR LOCATION.
DOI=10.1101/gad.1185804; PubMed=15075292 [NCBI, ExPASy, EBI, Israel, Japan]
Chen M.-H.,
Li Y.-J.,
Kawakami T.,
Xu S.-M.,
Chuang P.-T.;
"Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.";
Genes Dev. 18:641-659(2004).
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[10]
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INTERACTION WITH HHATL.
DOI=10.1111/j.1742-4658.2007.06202.x; PubMed=18081866 [NCBI, ExPASy, EBI, Israel, Japan]
Abe Y.,
Kita Y.,
Niikura T.;
"Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog.";
FEBS J. 275:318-331(2008).
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[11]
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X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 34-195.
DOI=10.1038/378212a0; PubMed=7477329 [NCBI, ExPASy, EBI, Israel, Japan]
Hall T.M.T.,
Porter J.A.,
Beachy P.A.,
Leahy D.J.;
"A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog.";
Nature 378:212-216(1995).
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