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UniProtKB/Swiss-Prot entry Q61E36

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MCES_CAEBR
Primary accession number Q61E36
Secondary accession number A8XEX5
Integrated into Swiss-Prot on September 5, 2006
Sequence was last modified on November 23, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 19)
Name and origin of the protein
Protein name mRNA cap guanine-N7 methyltransferase
Synonyms EC 2.1.1.56
mRNA (guanine-N(7)-)-methyltransferase
Gene name
Name: tag-72
ORFNames: CBG12234
From
Caenorhabditis briggsae [TaxID: 6238] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AF16;
DOI=10.1371/journal.pbio.0000045; PubMed=14624247 [NCBI, ExPASy, EBI, Israel, Japan]
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H.;
"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.";
PLoS Biol. 1:166-192(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CAAC02000508; CAP31197.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q61E36.
Organism-specific databases
WormBase WBGene00033215; CBG12234.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from sequence or structural similarity from UniProtKB).
GO:0004482; Molecular function: mRNA (guanine-N7-)-methyltransferase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0003723; Molecular function: RNA binding (inferred from sequence or structural similarity from UniProtKB).
GO:0006370; Biological process: mRNA capping (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR016899; mRNA_G-N7_MeTrfase.
IPR004971; Pox_MCEL.
Graphical view of domain structure.
Pfam PF03291; Pox_MCEL; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF028762; ABD1; 1.
BLOCKS Q61E36.
Other
ProtoNet Q61E36.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Methyltransferase; mRNA capping; mRNA processing; Nucleus; RNA-binding; S-adenosyl-L-methionine; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   378  378     mRNA cap guanine-N7 methyltransferase. PRO_0000248328
REGION   33    34  2     mRNA cap binding (By similarity). 
BINDING   37    37        S-adenosyl-L-methionine (By similarity). 
BINDING   62    62        S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). 
BINDING   65    65        mRNA cap (By similarity). 
BINDING   71    71        mRNA cap (By similarity). 
BINDING   84    84        S-adenosyl-L-methionine (By similarity). 
BINDING   96    96        mRNA cap (By similarity). 
BINDING   116   116        S-adenosyl-L-methionine (By similarity). 
BINDING   138   138        S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). 
BINDING   142   142        mRNA cap (By similarity). 
BINDING   229   229        mRNA cap (By similarity). 
BINDING   323   323        mRNA cap (By similarity). 
Sequence information
Length: 378 AA [This is the length of the unprocessed precursor] Molecular weight: 42956 Da [This is the MW of the unprocessed precursor] CRC64: 142763C0CADEA65F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSAAEVADHY NNVRQAGIQD RKESRIFFMR NMNNWIKSQL INDAMKLVNE NGVKSPVVLD 

        70         80         90        100        110        120 
IACGKGGDLR KWDITGAKHV VMADVADVSI QQAEERYKTM HKYPHDIFGA QFIVADCTKE 

       130        140        150        160        170        180 
NLDDKIEIKE PFDLVSCQFA MHYSFVDEDS ARTFLKNAVG KLKLGGVFIG TLPDADRIVW 

       190        200        210        220        230        240 
AVRNGTEGKF ANDVCKITYE KVDELSEGNV PLFGAKFHFS LDEQVNCPEF LAYFSLVKHL 

       250        260        270        280        290        300 
LEEHDMELLF VHNFAEAITN WLVPGRRLLE SMKGLETFPN RNLSGKTDEE YLEAKAKIDS 

       310        320        330        340        350        360 
LGDNVPKFVG TLSKSEWEAI CMYLVFGFRK KKTTEKNLES EAPEIKKVTP VPLNEDTDKT 

       370 
AEKNEERIEE KEENPSHC
Q61E36 in FASTA format

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