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UniProtKB/Swiss-Prot entry Q61288

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACVL1_MOUSE
Primary accession number Q61288
Secondary accession number Q61289
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 76)
Name and origin of the protein
Protein name Serine/threonine-protein kinase receptor R3 [Precursor]
Synonyms EC 2.7.11.30
SKR3
Activin receptor-like kinase 1
ALK-1
TGF-B superfamily receptor type I
TSR-I
Gene name
Name: Acvrl1
Synonyms: Acvrlk1, Alk-1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
DOI=10.1006/bbrc.1995.2594; PubMed=7488127 [NCBI, ExPASy, EBI, Israel, Japan]
Wu X., Robinson C.E., Fong H.W., Crabtree J.S., Rodriguez B.R., Roe B.A., Gimble J.M.;
"Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog.";
Biochem. Biophys. Res. Commun. 216:78-83(1995).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1210/en.136.6.2652; PubMed=7750489 [NCBI, ExPASy, EBI, Israel, Japan]
Dewulf N., Verschueren K., Lonnoy O., Moren A., Grimsby S., Spiegle K., Miyazono K., Huylebroeck D., ten Dijke P.;
"Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.";
Endocrinology 136:2652-2663(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L48015; AAB03642.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z31664; CAA83484.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I48241; I48241.
JC4337; JC4337.
RefSeq NP_033742.2; -.
UniGene Mm.279542
3D structure databases
HSSP P36897; 1IAS. [HSSP ENTRY / PDB]
ModBase Q61288.
PTM databases
PhosphoSite Q61288; -.
Organism-specific databases
MGI MGI:1338946; Acvrl1.
GeneLynx Acvrl1; Mus musculus.
Gene expression databases
ArrayExpress Q61288; -.
CleanEx MM_ACVRL1; -.
GermOnline ENSMUSG00000000530; Mus musculus.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from MGI).
GO:0001525; Biological process: angiogenesis (inferred from mutant phenotype from MGI).
GO:0001701; Biological process: in utero embryonic development (inferred from mutant phenotype from MGI).
GO:0007179; Biological process: transforming growth factor beta receptor signaling pathway (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR008271; Ser_thr_pkin_AS.
IPR003605; TGF_beta_rcpt_GS.
Graphical view of domain structure.
Pfam PF01064; Activin_recp; 1.
PF08515; TGF_beta_GS; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00467; GS; 1.
SMART graphical view of domain structure.
PROSITE PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q61288.
Genome annotation databases
Ensembl ENSMUSG00000000530; Mus musculus. [Contig view]
GeneID 11482; -.
KEGG mmu:11482; -.
Phylogenomic databases
HOGENOM Q61288; -.
HOVERGEN Q61288; -.
Other
SOURCE Acvrl1; Mus musculus.
ProtoNet Q61288.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    22  22     Potential. 
CHAIN   23   502  480     Serine/threonine-protein kinase receptor R3. PRO_0000024421
TOPO_DOM   23   119  97     Extracellular (Potential). 
TRANSMEM   120   140  21     Potential. 
TOPO_DOM   141   502  362     Cytoplasmic (Potential). 
DOMAIN   171   200  30     GS. 
DOMAIN   201   502  302     Protein kinase. 
NP_BIND   207   215  9     ATP (By similarity). 
ACT_SITE   329   329        Proton acceptor (By similarity). 
BINDING   228   228        ATP (By similarity). 
CARBOHYD   32    32        N-linked (GlcNAc...) (Potential). 
CARBOHYD   97    97        N-linked (GlcNAc...) (Potential). 
CONFLICT   17    17        F -> L (in Ref. 2; CAA83484). 
CONFLICT   21    21        R -> Q (in Ref. 2). 
CONFLICT   23    23        D -> R (in Ref. 2). 
CONFLICT   25    26        RR -> AK (in Ref. 2). 
CONFLICT   305   305        A -> P (in Ref. 2; CAA83484). 
CONFLICT   358   359        SD -> NE (in Ref. 2; CAA83484). 
CONFLICT   366   366        N -> T (in Ref. 2; CAA83484). 
Sequence information
Length: 502 AA [This is the length of the unprocessed precursor] Molecular weight: 56632 Da [This is the MW of the unprocessed precursor] CRC64: 092ABB29778BB004 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTLGSFRRGL LMLSVAFGLT RGDLRRPSKL VNCTCESPHC KRPFCQGSWC TVVLVREQGR 

        70         80         90        100        110        120 
HPQVYRGCGS LNQELCLGRP TEFLNHHCCY RSFCNHNVSL MLEATQTPSE EPEVDAHLPL 

       130        140        150        160        170        180 
ILGPVLALPV LVALGALGLW RVRRRQEKQR DLHSDLGESS LILKASEQAD SMLGDFLDSD 

       190        200        210        220        230        240 
CTTGSGSGLP FLVQRTVARQ VALVECVGKG RYGEVWRGSW HGESVAVKIF SSRDEQSWFR 

       250        260        270        280        290        300 
ETEIYNTVLL RHDNILGFIA SDMTSRNSST QLWLITHYHE HGSLYDFLQR QTLEPQLALR 

       310        320        330        340        350        360 
LAVSAACGLA HLHVEIFGTQ GKPAIAHRDL KSRNVLVKSN LQCCIADLGL AVMHSQSSDY 

       370        380        390        400        410        420 
LDIGNNPRVG TKRYMAPEVL DEHIRTDCFE SYKWTDIWAF GLVLWEIARR TIINGIVEDY 

       430        440        450        460        470        480 
RPPFYDMVPN DPSFEDMKKV VCVDQQTPTI PNRLAADPVL SGLAQMMREC WYPNPSARLT 

       490        500 
ALRIKKTLQK LSHNPEKPKV IH
Q61288 in FASTA format

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