ID   ACV1B_MOUSE             Reviewed;         505 AA.
AC   Q61271;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-SEP-2008, entry version 68.
DE   RecName: Full=Activin receptor type-1B;
DE            EC=2.7.11.30;
DE   AltName: Full=ACTR-IB;
DE   AltName: Full=Serine/threonine-protein kinase receptor R2;
DE            Short=SKR2;
DE   Flags: Precursor;
GN   Name=Acvr1b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=NIH Swiss; TISSUE=Placenta;
RX   MEDLINE=96076132; PubMed=7577669; DOI=10.1016/0925-4773(95)00395-H;
RA   Verschuern K., Dewulf N., Goumans M.J., Lonnoy O., Freijen A.,
RA   Grimsby S., Vande Spiegle K., ten Dijke P., Moren A.,
RA   Vanscheeuwijck P., Heldin C.H., Miyazono K., Mummery C.,
RA   Van Den Eijnden-Van Raaij J., Huylebroeck D.;
RT   "Expression of type I and type IB receptors for activin in
RT   midgestation mouse embryos suggests distinct functions in
RT   organogensis.";
RL   Mech. Dev. 52:109-123(1995).
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBUNIT: Interacts with AIP1. Part of a complex consisting of
CC       AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 GS domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; Z31663; CAA83483.1; -; mRNA.
DR   RefSeq; NP_031421.1; -.
DR   UniGene; Mm.308467; -.
DR   HSSP; P36897; 1B6C.
DR   SMR; Q61271; 178-501.
DR   PhosphoSite; Q61271; -.
DR   Ensembl; ENSMUSG00000000532; Mus musculus.
DR   GeneID; 11479; -.
DR   KEGG; mmu:11479; -.
DR   MGI; MGI:1338944; Acvr1b.
DR   HOGENOM; Q61271; -.
DR   HOVERGEN; Q61271; -.
DR   ArrayExpress; Q61271; -.
DR   CleanEx; MM_ACVR1B; -.
DR   GermOnline; ENSMUSG00000000532; Mus musculus.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:MGI.
DR   GO; GO:0048185; F:activin binding; IPI:MGI.
DR   GO; GO:0007166; P:cell surface receptor linked signal transdu...; TAS:MGI.
DR   GO; GO:0001942; P:hair follicle development; IMP:MGI.
DR   GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00467; GS; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24    505       Activin receptor type-1B.
FT                                /FTId=PRO_0000024418.
FT   TOPO_DOM     24    126       Extracellular (Potential).
FT   TRANSMEM    127    149       Potential.
FT   TOPO_DOM    150    505       Cytoplasmic (Potential).
FT   DOMAIN      177    206       GS.
FT   DOMAIN      207    497       Protein kinase.
FT   NP_BIND     213    221       ATP (By similarity).
FT   ACT_SITE    335    335       Proton acceptor (By similarity).
FT   BINDING     234    234       ATP (By similarity).
FT   MOD_RES     380    380       Phosphotyrosine (By similarity).
FT   CARBOHYD     43     43       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   505 AA;  56700 MW;  56E9EEF1607A2517 CRC64;
     MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG ACMVSIFNLD
     GVEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF CNKIDLRVPS GHLKEPAHPS
     MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ
     DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE
     ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT
     IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH
     DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG
     GVHEDYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNVPNWW QSYEALRVMG KMMRECWYAN
     GAARLTALRI KKTLSQLSVQ EDVKI
//