NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Rowbotham-Bradford;
DOI=10.1126/science.1101485; PubMed=15486256 [NCBI, ExPASy, EBI, Israel, Japan]
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.;
"The 1.2-megabase genome sequence of Mimivirus.";
Science 306:1344-1350(2004).

Comments

FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity).
CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
PATHWAY: Protein modification; protein ubiquitination .
SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY653733; AAV50969.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_143063.1; -.

3D structure databases

ModBase

Q5UQ57.

Family and domain databases

InterPro

IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.

PANTHER

PTHR11621; UBQ-conjugat_E2; 1.

Pfam

PF00179; UQ_con; 1.
Pfam graphical view of domain structure.

ProDom

PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00212; UBCc; 1.
SMART graphical view of domain structure.

PROSITE

PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q5UQ57.

Genome annotation databases

GeneID

3162972; -.

Other

ProtoNet

Q5UQ57.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Ligase; Ubl conjugation pathway.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 388`	`388`	`Probable ubiquitin-conjugating enzyme E2 L709.`	`PRO_0000243981`
`ACT_SITE`	`95 95`		`Glycyl thioester intermediate (By similarity).`

Sequence information

Length: 388 AA [This is the length of the unprocessed precursor]

Molecular weight: 42724 Da [This is the MW of the unprocessed precursor]

CRC64: 9329EB6E7F020B78 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQNVHKRVIK DINDGMKNLK QEFGIYLAPE EDDFYKVHFI LQGPEGTPFE GGLYHGMIRL 

        70         80         90        100        110        120 
NNDHPFRPPN LHMITPSGRF EAEKYPISPN SRGICTTATS FHPESWTSMN NLETVLKGFV 

       130        140        150        160        170        180 
SLMCDPYDGG VGAVKSTDTQ VKKLAQDSLT HIGNDLMVQK LFPDLYKAVN NGTFKPVKLA 

       190        200        210        220        230        240 
ELSKIVYKEP TKPIVEEKSA KTSKSSTKTS VKSKKNQKSD SEEEENSDDD NTDSDSESDD 

       250        260        270        280        290        300 
FRDLDDVVDD SDQESDDESD SSSESENESG GSDDESDDGS DDESDDETSE SDSESEEEKP 

       310        320        330        340        350        360 
VKKSTRKISK TTTKSSSTKP VKSIKSSKST TTKPTKPTKS TKTTKSTKST KSTKSTKPTE 

       370        380 
STKSSRSVKT TESSKSSKSS KSSKTGKK

Q5UQ57 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools