NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Doberman pinscher;
DOI=10.1016/j.ygeno.2004.09.009; PubMed=15607421 [NCBI, ExPASy, EBI, Israel, Japan]
Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A., Ollier W.E.R., Binns M.M.;
"Genomic sequence of the class II region of the canine MHC: comparison with the MHC of other mammalian species.";
Genomics 85:48-59(2005).

Comments

FUNCTION: Uses estradiol as its preferred substrate (By similarity).
CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)⁺ = estrone + NAD(P)H.
CATALYTIC ACTIVITY: Testosterone + NAD⁺ = androst-4-ene-3,17-dione + NADH.
PATHWAY: Steroid metabolism; estrogen biosynthesis .
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ630366; CAI11433.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q5TJF5.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

Q5TJF5.

Genome annotation databases

Ensembl

ENSCAFG00000000927; Canis familiaris. [Contig view]

Phylogenomic databases

HOVERGEN

Q5TJF5; -.

Other

ProtoNet

Q5TJF5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Lipid synthesis; NAD; Oxidoreductase; Steroid biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 259`	`259`	`Estradiol 17-beta-dehydrogenase 8.`	`PRO_0000054597`
`NP_BIND`	`13 37`	`25`	`NAD (By similarity).`
`ACT_SITE`	`167 167`		`Proton acceptor (By similarity).`
`BINDING`	`154 154`		`Substrate (By similarity).`

Sequence information

Length: 259 AA [This is the length of the unprocessed precursor]

Molecular weight: 26712 Da [This is the MW of the unprocessed precursor]

CRC64: 40AA25885DE5E197 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASPLRLRSA LALVTGAGSG IGRAVSVRLA KEGATVAACD LDRAAACETV WLLGGQGSEK 

        70         80         90        100        110        120 
VAPGGAHTAF QADVSEAGAV RRLLEQVQAC FSRPPSVVVS CAGLTRDEFL LRMSEDDWDR 

       130        140        150        160        170        180 
VIAVNLKGIF LVTQAAAQAL VSSGCRGSII NISSIVGKVG NVGQTNYAAS KAGVIGLTQT 

       190        200        210        220        230        240 
AARELGRHGI RCNSVLPGFI TTPMTQKVPQ KVLDKVIGMI PMGHLGDPED VADAVTFLAS 

       250 
EDSGYITGAS VEVTGGLYM

Q5TJF5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools