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UniProtKB/Swiss-Prot entry Q5R7C9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AK1C3_PONAB
Primary accession number Q5R7C9
Secondary accession numbers None
Integrated into Swiss-Prot on July 19, 2005
Sequence was last modified on December 21, 2004 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 19)
Name and origin of the protein
Protein name Aldo-keto reductase family 1 member C3 homolog
Synonyms EC 1.-.-.-
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC 1.3.1.20
3-alpha-hydroxysteroid dehydrogenase type 2
3-alpha-HSD type 2
EC 1.1.1.213
Testosterone 17-beta-dehydrogenase 5
EC 1.1.1.63
EC 1.1.1.64
17-beta-hydroxysteroid dehydrogenase type 5
17-beta-HSD 5
Prostaglandin F synthase
PGFS
EC 1.1.1.188
Gene name
Name: AKR1C3
From
Pongo abelii (Sumatran orangutan) [TaxID: 9601] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone (By similarity).
  • CATALYTIC ACTIVITY: Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.
  • CATALYTIC ACTIVITY: Androsterone + NAD(P)+ = 5-alpha-androstane-3,17-dione + NAD(P)H.
  • CATALYTIC ACTIVITY: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.
  • CATALYTIC ACTIVITY: Testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.
  • CATALYTIC ACTIVITY: Testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH.
  • SIMILARITY: Belongs to the aldo/keto reductase family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR860189; CAH92331.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
SMR Q5R7C9; 6-320.
ModBase Q5R7C9.
Family and domain databases
InterPro IPR001395; Aldo/ket_red.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.100; Aldo/ket_red; 1.
PANTHER PTHR11732; Aldo/ket_red; 1.
Pfam PF00248; Aldo_ket_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00069; ALDKETRDTASE.
ProDom PD000288; Aldo/ket_red; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00798; ALDOKETO_REDUCTASE_1; 1.
PS00062; ALDOKETO_REDUCTASE_2; 1.
PS00063; ALDOKETO_REDUCTASE_3; 1.
BLOCKS Q5R7C9.
Phylogenomic databases
HOVERGEN Q5R7C9; -.
Other
ProtoNet Q5R7C9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   323  323     Aldo-keto reductase family 1 member C3 homolog. PRO_0000124639
NP_BIND   13    22  10     NADP (Potential). 
NP_BIND   217   280  64     NADP (By similarity). 
ACT_SITE   55    55        Proton donor (By similarity). 
BINDING   117   117        Substrate (By similarity). 
SITE   54    54  1     Important for substrate specificity (By similarity). 
SITE   84    84  1     Lowers pKa of active site Tyr (By similarity). 
SITE   227   227  1     Involved in ligand recognition and product release (By similarity). 
SITE   306   306  1     Involved in ligand recognition and product release (By similarity). 
Sequence information
Length: 323 AA [This is the length of the unprocessed precursor] Molecular weight: 36848 Da [This is the MW of the unprocessed precursor] CRC64: DCAD6ECA97C204AB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ 

        70         80         90        100        110        120 
VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM 

       130        140        150        160        170        180 
SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEECKDAGLA KSIGVSNFNR RQLEMILNKP 

       190        200        210        220        230        240 
GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV 

       250        260        270        280        290        300 
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIREN VQVFEFQLTA EDMRAIDGLN 

       310        320 
RNLHYFNSDS LASHPNYPYS DEY
Q5R7C9 in FASTA format

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