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UniProtKB/Swiss-Prot entry Q5R5E7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 3HIDH_PONAB
Primary accession number Q5R5E7
Secondary accession numbers None
Integrated into Swiss-Prot on June 12, 2007
Sequence was last modified on December 21, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 28)
Name and origin of the protein
Protein name 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Precursor]
Synonyms HIBADH
EC 1.1.1.31
Gene name
Name: HIBADH
From
Pongo abelii (Sumatran orangutan) [TaxID: 9601] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR860914; CAH93019.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
SMR Q5R5E7; 41-335.
ModBase Q5R5E7.
Family and domain databases
InterPro IPR002204; 3-OH-isobutyrate_DHase-rel_CS.
IPR015815; 3hydroxyacid_DHase/Rdtase.
IPR006183; 6-phosphogluconate_DHase.
IPR006115; 6PGDH_NAD-bd.
IPR013328; DHase_multihelical.
IPR011548; IsoBut3OH_DH.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR22981; 3hydroxy_acid_DH; 1.
Pfam PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00076; 6PGDHDRGNASE.
TIGRFAMs TIGR01692; HIBADH; 1.
PROSITE PS00895; 3_HYDROXYISOBUT_DH; 1.
BLOCKS Q5R5E7.
Phylogenomic databases
HOVERGEN Q5R5E7; -.
Other
ProtoNet Q5R5E7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    36  36     Mitochondrion (By similarity). 
CHAIN   37   336  300     3-hydroxyisobutyrate dehydrogenase, mitochondrial. PRO_0000290341
NP_BIND   40    69  30     NAD (By similarity). 
NP_BIND   103   104  2     NAD (By similarity). 
ACT_SITE   209   209        By similarity. 
BINDING   108   108        NAD (By similarity). 
BINDING   134   134        NAD; via amide nitrogen (By similarity). 
BINDING   284   284        NAD (By similarity). 
Sequence information
Length: 336 AA [This is the length of the unprocessed precursor] Molecular weight: 35299 Da [This is the MW of the unprocessed precursor] CRC64: DA243D775F84AF48 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAASLRLLGA ASGLRYWSRR LRPAAGSFAA VCSRSVASKT PVGFIGLGNM GNPMAKNLMK 

        70         80         90        100        110        120 
HGYPLIIYDV FPDACKEFQD AGEQVVSSPA DVAEKADRII TMLPTSINAI EAYSGANGIL 

       130        140        150        160        170        180 
KKVKKGSLLI DSSTIDPAVS KELAKEVEKM GAVFMDAPVS GGVGAARSGN LTFMVGGVED 

       190        200        210        220        230        240 
EFAAAQELLG CMGSNVVYCG AVGTGQAAKI CNNMLLAISM IGTAEAMNLG IRLGLDPKLL 

       250        260        270        280        290        300 
AKILNMSSGR CWSSDTYNPV PGVMDGVPSA NNYQGGFGAT LMAKDLGLAQ DSATSTKSPI 

       310        320        330 
LLGSLAHQIY RMMCAKGYSK KDFSSVFQFL REEETF
Q5R5E7 in FASTA format

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