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UniProtKB/Swiss-Prot entry Q5QWC6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_IDILO
Primary accession number Q5QWC6
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on January 4, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 22)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: IL0362
From
Idiomarina loihiensis [TaxID: 135577] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales; Idiomarinaceae; Idiomarina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=L2-TR / ATCC BAA-735 / DSM 15497;
DOI=10.1073/pnas.0407638102; PubMed=15596722 [NCBI, ExPASy, EBI, Israel, Japan]
Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J., Aizawa S., Shibata S., Malahoff A., Alam M.;
"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy.";
Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017340; AAV81205.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_154754.1; -.
3D structure databases
ModBase Q5QWC6.
Enzyme and pathway databases
BioCyc ILOI283942:IL0362-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00219; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004721; DHOdimr.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001237; DHOdimr; 1.
TIGRFAMs TIGR00856; pyrC_dimer; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q5QWC6.
Genome annotation databases
GeneID 3172502; -.
GenomeReviews AE017340_GR; IL0362.
KEGG ilo:IL0362; -.
NMPDR fig|283942.3.peg.446; -.
Phylogenomic databases
HOGENOM Q5QWC6; -.
Genome annotation databases
CMR Q5QWC6; IL0362.
Other
ProtoNet Q5QWC6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   344  344     Dihydroorotase. PRO_1000024018
METAL   13    13        Zinc 1 (By similarity). 
METAL   15    15        Zinc 1 (By similarity). 
METAL   99    99        Zinc 1; via carbamate group (By similarity). 
METAL   99    99        Zinc 2; via carbamate group (By similarity). 
METAL   136   136        Zinc 2 (By similarity). 
METAL   174   174        Zinc 2 (By similarity). 
METAL   247   247        Zinc 1 (By similarity). 
MOD_RES   99    99        N6-carboxylysine (By similarity). 
Sequence information
Length: 344 AA [This is the length of the unprocessed precursor] Molecular weight: 37656 Da [This is the MW of the unprocessed precursor] CRC64: 0524427E85F4BD41 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQSLTIPRPD DWHLHLRDGA MLQTTVPATA AVFHRAVVMP NLVPPVTTVA AAMEYRERIL 

        70         80         90        100        110        120 
AEIPAGMSFN PLMALYLTAD TTPAEIAEAA ANEHVIGFKL YPSGATTNSA AGVKSVEALA 

       130        140        150        160        170        180 
PVLAAMQEHQ VPLLVHGEVT DSDIDIFDRE RVFIERHLIP ITERFPQLKL VLEHITTADA 

       190        200        210        220        230        240 
VKFVENANSN VAATMTPQHL LMNRNDLLVG GIRPHNYCLP ILKRRSHQQA LQQAALSGNP 

       250        260        270        280        290        300 
KFFLGTDSAP HVQANKETAC GCAGCYSAPA AIELYAEFFS QHNALDKLAN FASVFGADFY 

       310        320        330        340 
QLPRNTETIE LVQQPWTVAE TVDTATGPMV PYWAGSDLQW KLRG
Q5QWC6 in FASTA format

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