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UniProtKB/Swiss-Prot entry Q5PAV3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ANAMM
Primary accession number Q5PAV3
Secondary accession numbers None
Integrated into Swiss-Prot on August 30, 2005
Sequence was last modified on January 4, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 27)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: AM564
From
Anaplasma marginale (strain St. Maries) [TaxID: 234826] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Anaplasmataceae; Anaplasma.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0406656102; PubMed=15618402 [NCBI, ExPASy, EBI, Israel, Japan]
Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L., Palmer G.H., McGuire T.C., Knowles D.P. Jr.;
"Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins.";
Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000030; AAV86577.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_153832.1; -.
3D structure databases
ModBase Q5PAV3.
Enzyme and pathway databases
BioCyc AMAR234826:AM564-MON; -.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00487; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR011275; Malate_DHase_NAD-dep_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01763; MalateDH_bact; 1.
BLOCKS Q5PAV3.
Genome annotation databases
GeneID 3171816; -.
GenomeReviews CP000030_GR; AM564.
KEGG ama:AM564; -.
Phylogenomic databases
HOGENOM Q5PAV3; -.
Genome annotation databases
CMR Q5PAV3; AM564.
Other
ProtoNet Q5PAV3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   317  317     Malate dehydrogenase. PRO_0000113420
NP_BIND   13    18  6     NAD (By similarity). 
NP_BIND   123   125  3     NAD (By similarity). 
ACT_SITE   180   180        Proton acceptor (By similarity). 
BINDING   38    38        NAD (By similarity). 
BINDING   87    87        Substrate (By similarity). 
BINDING   93    93        Substrate (By similarity). 
BINDING   100   100        NAD (By similarity). 
BINDING   125   125        Substrate (By similarity). 
BINDING   156   156        Substrate (By similarity). 
Sequence information
Length: 317 AA [This is the length of the unprocessed precursor] Molecular weight: 33379 Da [This is the MW of the unprocessed precursor] CRC64: 65C4ED86C35C6D0B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRSSRSAKVS LVGAGNIGGA LAHMLGASQV VKELVLVDVA GGMTEGKVLD VGQALALLGS 

        70         80         90        100        110        120 
DVYITGGSDY AAIEHSDAVV VTAGIPRKEG MSREDLLNTN AAVVRNIAEN IAKYSPGALV 

       130        140        150        160        170        180 
IVVTNPLDAM VWCMYKYSGL PANRVVGMAG VLDSARFSFF LARHMNVSVS SVSAMVLGGH 

       190        200        210        220        230        240 
GDLMLPLLRY STVGGVPVES LIESGRLNRD DIAAIVERTR KGGEEIVKLL KTGSAYCAPA 

       250        260        270        280        290        300 
ASCAHMLESY VRDKRSIMPC SAYLDGQYGV RDLFVGVPVI IGEKGVEEVV EFPLTAEEQA 

       310 
VFDQSVELIR GSVSAIS
Q5PAV3 in FASTA format

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