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UniProtKB/Swiss-Prot entry Q5L0U5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_GEOKA
Primary accession number Q5L0U5
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on February 1, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 24)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: GK1150
From
Geobacillus kaustophilus [TaxID: 1462] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Geobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HTA426;
DOI=10.1093/nar/gkh970; PubMed=15576355 [NCBI, ExPASy, EBI, Israel, Japan]
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.;
"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus.";
Nucleic Acids Res. 32:6292-6303(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000043; BAD75435.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_147003.1; -.
3D structure databases
ModBase Q5L0U5.
Enzyme and pathway databases
BioCyc GKAU235909:GK1150-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q5L0U5.
Genome annotation databases
GeneID 3185137; -.
GenomeReviews BA000043_GR; GK1150.
KEGG gka:GK1150; -.
NMPDR fig|235909.3.peg.2213; -.
Phylogenomic databases
HOGENOM Q5L0U5; -.
Genome annotation databases
CMR Q5L0U5; GK1150.
Other
ProtoNet Q5L0U5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Dihydroorotase. PRO_1000024083
METAL   61    61        Zinc 1 (By similarity). 
METAL   63    63        Zinc 1 (By similarity). 
METAL   143   143        Zinc 1; via carbamate group (By similarity). 
METAL   143   143        Zinc 2; via carbamate group (By similarity). 
METAL   180   180        Zinc 2 (By similarity). 
METAL   233   233        Zinc 2 (By similarity). 
METAL   306   306        Zinc 1 (By similarity). 
MOD_RES   143   143        N6-carboxylysine (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46177 Da [This is the MW of the unprocessed precursor] CRC64: 51B1DC25EE06C01A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGVWLKNGMS FNKDGELMRT HIKIEHGTIA AILYEQPLEA NEEDVIDVGG RLIVPGLIDL 

        70         80         90        100        110        120 
HVHLREPGGE AKETIETGTL AAAKGGFTTV AAMPNTNPAP DRKEQMEWLQ ARIRETARVN 

       130        140        150        160        170        180 
VLPYAAITIG QKGEELTDFA ALKEAGAFAF TDDGVGVQSA GMMFEAMKQA AALDMAIVAH 

       190        200        210        220        230        240 
CEDDTLTNGG AVHDGEFARR YGLRGIPSVC EAVHIARDVL LAEAAGCHYH VCHISTKESV 

       250        260        270        280        290        300 
RVVRDAKRAG IRVTAEVTPH HLLLCDEDIP GLDANYKMNP PLRSREDRDA LIEGLLDGTI 

       310        320        330        340        350        360 
DFIATDHAPH TAAEKAKGIE AAPFGIVGLE TAFPLLYTHF VKTGVFTLKQ LVDWLTIKPA 

       370        380        390        400        410        420 
QCFGLKAGRL AVGAPADIAV IDLETEEAID PETFASKGKN TPFAGWVCQG WPVMTFVGGT 


LVWEKGRA
Q5L0U5 in FASTA format

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