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UniProtKB/Swiss-Prot entry Q5K9S5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNL4_CRYNE
Primary accession number Q5K9S5
Secondary accession number Q55JS6
Integrated into Swiss-Prot on February 20, 2007
Sequence was last modified on February 15, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 25)
Name and origin of the protein
Protein name DNA ligase 4
Synonyms EC 6.5.1.1
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene name
Name: LIG4
OrderedLocusNames: CNK00930, CNBK2570
From
Cryptococcus neoformans (Filobasidiella neoformans) [TaxID: 5207] 
Taxonomy Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Tremellaceae; Filobasidiella.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=B-3501A, and JEC21;
DOI=10.1126/science.1103773; PubMed=15653466 [NCBI, ExPASy, EBI, Israel, Japan]
Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.";
Science 307:1321-1324(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017351; AAW46139.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAEY01000052; EAL18239.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_567656.1; -.
XP_772886.1; -.
UniGene Fne.4294
3D structure databases
ModBase Q5K9S5.
Family and domain databases
InterPro IPR001357; BRCT.
IPR000977; DNA_ligase.
IPR012310; DNA_ligase_A_M.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF00533; BRCT; 2.
PF01068; DNA_ligase_A_M; 1.
Pfam graphical view of domain structure.
SMART SM00292; BRCT; 2.
SMART graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS50172; BRCT; 2.
PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q5K9S5.
Genome annotation databases
GeneID 3254392; -.
4938955; -.
GenomeReviews AE017351_GR; CNK00930.
KEGG cnb:CNBK2570; -.
cne:CNK00930; -.
Phylogenomic databases
HOGENOM Q5K9S5; -.
Other
ProtoNet Q5K9S5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Nucleus; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1065  1065     DNA ligase 4. PRO_0000278381
DOMAIN   696    775  80     BRCT 1. 
DOMAIN   954   1064  111     BRCT 2. 
ACT_SITE   297    297        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 1065 AA [This is the length of the unprocessed precursor] Molecular weight: 122466 Da [This is the MW of the unprocessed precursor] CRC64: 7E0AC640AB2D6236 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAVHAPYNHA PPPTQEINGQ KPTLAPAITL ERPADCINRG QYPAFYIICG YLNRLRADAP 

        70         80         90        100        110        120 
HKKYELLTRI FGNWREKVGP DLYPLIRLLL PDKDRERPVY NLKESMLARC YIDILSLEKH 

       130        140        150        160        170        180 
SEAAQRLIKW KQPAGNSPNP TGDFAKVCYN EIKARSTVEE GQLSVEAVNM LLDKLAVGKM 

       190        200        210        220        230        240 
KQKDYVPILK AINMQCTAEE QEWIIRIILK DLHISIRERG VLSAFHPDAI DLYNVCSDLK 

       250        260        270        280        290        300 
RVCWTLYDPG FRLNKNETHL ELFHSFLPQL CGRMNDASLE NIAKAIGAPK EFIMEEKLDG 

       310        320        330        340        350        360 
ERIQLHMRGN GAQWFYCSRK AKDYTYLYGA HPGEGSLTRY IATAFQDNVR NVILDGEMMV 

       370        380        390        400        410        420 
WDPVVERYLA FGTLKSAALA FSLVKVFDIL FLNDHCLSRK RLSERKRLLR SGKIFKNIEN 

       430        440        450        460        470        480 
YKGRLEFVDE KRGKNAKDIR EYLERVVETK GEGLVVKKTD VIYQTNSRGY DWIKVKPEYS 

       490        500        510        520        530        540 
DQMGENLEVL VLGGWWGKGG RSGKISRLLC GLREQAFDDG TLQDFLFNRF WNELLGLRVD 

       550        560        570        580        590        600 
FVSHLMHLRS MRCSPTHLSQ CRNKHKKHWR PFDRSNPPPF MKLGPVGLDD KPDVYIEPEN 

       610        620        630        640        650        660 
SFVIEVKASE IVPAGYGIGF TLRFPRCKYI YYDKNSRDYA LDDECLWTVG QGFFYKTRKL 

       670        680        690        700        710        720 
IKRTDFMDLF SRPKRSYDDS QGPGNFRGQK LSDADVETSI FSDMTFSDLE ALVHKHGADF 

       730        740        750        760        770        780 
TQAQLSDLSA IVISPDQKNP LVRAQIRHGV NVIKPEWVFE SIARRTALPF LKEFLVFASE 

       790        800        810        820        830        840 
EAQDGRYYNK TLEQYDKVSF VRDRTGGALV DEDGDADVED EIMDGEDKDE IDVEESRESK 

       850        860        870        880        890        900 
NRRMAREDLK EKESNRTLEQ KKLQEAWGLR SRASPGDSDS EPEEEMSLKE ESDTDSERSR 

       910        920        930        940        950        960 
GLRAIYEDEE DGENDSHESD VGVNGDDYRA VPLSGLNDKE EGLMGESPEA MHYDEDRIFY 

       970        980        990       1000       1010       1020 
HLAFYIDTAK NAAVNGLESS SPSFDTQERL VKVEKLLIEN GGRVARSISD PKLTHIIMDD 

      1030       1040       1050       1060 
EDSRRYVELT RKTAMPKRKH IVTPKWVEDC VDEETLLDED LYKPK 

Q5K9S5 in FASTA format

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View entry in raw text format (no links)
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