NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=621H;
DOI=10.1038/nbt1062; PubMed=15665824 [NCBI, ExPASy, EBI, Israel, Japan]
Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.;
"Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans.";
Nat. Biotechnol. 23:195-200(2005).

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000004; AAW59662.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_190318.1; -.

3D structure databases

ModBase

Q5HXU1.

Enzyme and pathway databases

BioCyc

GOXY290633:GOX2598-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; atypical; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00594; polc; 1.

BLOCKS

Q5HXU1.

Genome annotation databases

GeneID

3248493; -.

GenomeReviews

CP000004_GR; GOX2598.

KEGG

gox:GOX2598; -.

NMPDR

fig|290633.1.peg.2527; -.

Phylogenomic databases

HOGENOM

Q5HXU1; -.

Genome annotation databases

CMR

Q5HXU1; GOX2598.

Other

ProtoNet

Q5HXU1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Plasmid; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 901`	`901`		`Error-prone DNA polymerase.`	`PRO_0000103380`

Sequence information

Length: 901 AA [This is the length of the unprocessed precursor]

Molecular weight: 100168 Da [This is the MW of the unprocessed precursor]

CRC64: 56F6240D81383D72 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAMYCEPRSE WWTRLPAPGG HRAWIACSSA LSRSAVLAGT PARLPVSTSA FLTHSFSVCA 

        70         80         90        100        110        120 
EQPILLAIDT IAVQRDGCSP SCSRTRRTAR ERTSGENFFT GLLIRPSSQV NRSPLIPGRF 

       130        140        150        160        170        180 
NPTETERTGE SAQETLTRLV QAALPRRYPA GAPPEVETQI AHELRLIGSL SYAPYFLTVN 

       190        200        210        220        230        240 
TIVRHARSLG IVCQGRGSAA NSAVCYVLGI TSIDPVRSGL LFERFISTER QEPPDIDVDF 

       250        260        270        280        290        300 
ESDRREEVIQ WIYRHYGRHR AALCATVQRY QPKGALREVG KVLGLPEDLT GQLSKHIASS 

       310        320        330        340        350        360 
LADPDLCKAR AADLGLNLKD RRLSLTFHLA RLLLGFPRQL GTHPGGFVLT EDRLDELVPL 

       370        380        390        400        410        420 
MPTAMDGRQI IVWDKDDIDV LRFMKVDVLG LGMLGCLRRG FELLHTVYQT RMDLAAIPAE 

       430        440        450        460        470        480 
DPQTYRMVQK ADTLGTFQIE SRAQMSMLPR MKPATFYDLV IQVAIVRPGP IQGDMVHPYL 

       490        500        510        520        530        540 
RRREKLEPVT YPSETLRGIL GKTLGVPLFQ EQAMQVAIHC AGFTPGEADQ LRRAMATFKM 

       550        560        570        580        590        600 
TGGVSPFRDK LVNGMLANGY EQEFAEQTFA QLEGFGSYGF PESHAASFAL IAYASAWMKC 

       610        620        630        640        650        660 
HYPDVFCAAL LNSQPMGFYA PSQIVQDAQR HGVEVRPICI NASRWDCTLE RGRNGRHAAV 

       670        680        690        700        710        720 
RLGFRMVKGL ANGHGAALIA ARMPDYESID DVWRRADVPV AALKCLAEAD AFRVFGQMRR 

       730        740        750        760        770        780 
AALWSIKGLA DTALPLFEAA DRGRNFPLPE VIEPEITLPM MSERASVHED YRATGLSLNG 

       790        800        810        820        830        840 
HPVAFLREGL RKEGIVRCGD LPYLRDGRRI QLTGLVLMRQ RPGTANGTMF VTIEDETGTA 

       850        860        870        880        890        900 
NLIVWKDVQE KYRRPLLASR LLACKGRLQK EGDVIHVVVL SLEDRTPLLQ GSEPLKARDF 


R

Q5HXU1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools