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UniProtKB/Swiss-Prot entry Q5HEB7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDL_STAAC
Primary accession number Q5HEB7
Secondary accession numbers None
Integrated into Swiss-Prot on July 19, 2005
Sequence was last modified on February 15, 2005 (Sequence version 1)
Annotations were last modified on    April 29, 2008 (Entry version 31)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase
Synonyms EC 6.3.2.4
D-alanylalanine synthetase
D-Ala-D-Ala ligase
Gene name
Name: ddl
OrderedLocusNames: SACOL2074
From
Staphylococcus aureus (strain COL) [TaxID: 93062] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.187.7.2426-2438.2005; PubMed=15774886 [NCBI, ExPASy, EBI, Israel, Japan]
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.;
"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain.";
J. Bacteriol. 187:2426-2438(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000046; AAW37036.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_186890.1; -.
3D structure databases
PDB
2I80; X-ray; 2.19 A; A/B=1-356.[ExPASy / RCSB / EBI]
2I87; X-ray; 2.00 A; A/B=1-356.[ExPASy / RCSB / EBI]
2I8C; X-ray; 2.46 A; A/B=1-356.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2I80; -.
2I87; -.
2I8C; -.
ModBase Q5HEB7.
Enzyme and pathway databases
BioCyc SAUR93062:SACOL2074-MON; -.
Ontologies
GO
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q5HEB7.
Genome annotation databases
GeneID 3238133; -.
GenomeReviews CP000046_GR; SACOL2074.
KEGG sac:SACOL2074; -.
TIGR SACOL2074; -.
Other
ProtoNet Q5HEB7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   356  356     D-alanine--D-alanine ligase. PRO_0000177874
DOMAIN   134   339  206     ATP-grasp. 
NP_BIND   167   222  56     ATP (By similarity). 
METAL   293   293        Magnesium or manganese 1 (By similarity). 
METAL   306   306        Magnesium or manganese 1 (By similarity). 
METAL   306   306        Magnesium or manganese 2 (By similarity). 
METAL   308   308        Magnesium or manganese 2 (By similarity). 
STRAND   4    11  8      
HELIX   17    29  13      
TURN   33    35  3      
STRAND   36    43  8      
STRAND   49    52  4      
HELIX   62    64  3      
HELIX   67    69  3      
STRAND   70    73  4      
HELIX   77    80  4      
STRAND   85    87  3      
STRAND   89    95  7      
STRAND   98   103  6      
HELIX   104   111  8      
STRAND   116   118  3      
HELIX   121   127  7      
HELIX   130   139  10      
STRAND   147   151  5      
HELIX   152   169  18      
STRAND   172   183  12      
STRAND   188   192  5      
HELIX   193   203  11      
TURN   204   206  3      
STRAND   208   214  7      
STRAND   219   230  12      
STRAND   237   239  3      
STRAND   259   262  4      
HELIX   267   283  17      
STRAND   287   296  10      
STRAND   302   310  9      
HELIX   318   324  7      
TURN   325   327  3      
Sequence information
Length: 356 AA [This is the length of the unprocessed precursor] Molecular weight: 40231 Da [This is the MW of the unprocessed precursor] CRC64: 65822883958DC645 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTKENICIVF GGKSAEHEVS ILTAQNVLNA IDKDKYHVDI IYITNDGDWR KQNNITAEIK 

        70         80         90        100        110        120 
STDELHLENG EALEISQLLK ESSSGQPYDA VFPLLHGPNG EDGTIQGLFE VLDVPYVGNG 

       130        140        150        160        170        180 
VLSAASSMDK LVMKQLFEHR GLPQLPYISF LRSEYEKYEH NILKLVNDKL NYPVFVKPAN 

       190        200        210        220        230        240 
LGSSVGISKC NNEAELKEGI KEAFQFDRKL VIEQGVNARE IEVAVLGNDY PEATWPGEVV 

       250        260        270        280        290        300 
KDVAFYDYKS KYKDGKVQLQ IPADLDEDVQ LTLRNMALEA FKATDCSGLV RADFFVTEDN 

       310        320        330        340        350 
QIYINETNAM PGFTAFSMYP KLWENMGLSY PELITKLIEL AKERHQDKQK NKYKID
Q5HEB7 in FASTA format

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