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UniProtKB/Swiss-Prot entry Q5FMB0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH1_LACAC
Primary accession number Q5FMB0
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2006
Sequence was last modified on March 1, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name L-lactate dehydrogenase 1
Synonyms L-LDH 1
EC 1.1.1.27
Gene name
Name: ldh1
OrderedLocusNames: LBA0271
From
Lactobacillus acidophilus [TaxID: 1579] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCFM;
DOI=10.1073/pnas.0409188102; PubMed=15671160 [NCBI, ExPASy, EBI, Israel, Japan]
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.;
"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM.";
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000033; AAV42164.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_193195.1; -.
3D structure databases
ModBase Q5FMB0.
Enzyme and pathway databases
BioCyc LACI272621:LBA0271-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q5FMB0.
Genome annotation databases
GeneID 3252415; -.
GenomeReviews CP000033_GR; LBA0271.
KEGG lac:LBA0271; -.
NMPDR fig|272621.3.peg.310; -.
Phylogenomic databases
HOGENOM Q5FMB0; -.
Genome annotation databases
CMR Q5FMB0; LBA0271.
Other
ProtoNet Q5FMB0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   323  323     L-lactate dehydrogenase 1. PRO_0000237547
NP_BIND   16    44  29     NAD (By similarity). 
ACT_SITE   179   179        Proton acceptor. 
BINDING   92    92        Substrate (By similarity). 
BINDING   124   124        NAD or substrate (By similarity). 
BINDING   155   155        Substrate (By similarity). 
BINDING   232   232        Substrate (By similarity). 
MOD_RES   223   223        Phosphotyrosine (By similarity). 
Sequence information
Length: 323 AA [This is the length of the unprocessed precursor] Molecular weight: 35039 Da [This is the MW of the unprocessed precursor] CRC64: DD2B0FFBC2ADA228 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MARVEKPRKV ILVGDGAVGS TFAFSMVQQG IAEELGIIDI AKEHVEGDAI DLADATPWTF 

        70         80         90        100        110        120 
PKNIYAADYA DCKDADLVVI TAGAPQKPGE TRLDLVNKNL KILSSIVEPV VESGFEGIFL 

       130        140        150        160        170        180 
VVANPVDILT HATWKISGFP KDRVIGSGTS LDTGRLQKVI GKMEHVDPRS VNAYMLGEHG 

       190        200        210        220        230        240 
DTEFPVWSYN NVGGVKVSDW VKAHGMDESK LEEIHKEVAD MAYDIINKKG ATFYGIGTAS 

       250        260        270        280        290        300 
AMIAKAILND EHRVLPLSVA MDGQYGLHDL HIGTPAVVGR NGLEQIIEMP LTADEQAKME 

       310        320 
ASAKQLKEVM DKAFEETGVK VRQ
Q5FMB0 in FASTA format

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