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UniProtKB/Swiss-Prot entry Q5FKK7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_LACAC
Primary accession number Q5FKK7
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2006
Sequence was last modified on March 1, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 28)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldh2
OrderedLocusNames: LBA0910
From
Lactobacillus acidophilus [TaxID: 1579] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCFM;
DOI=10.1073/pnas.0409188102; PubMed=15671160 [NCBI, ExPASy, EBI, Israel, Japan]
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.;
"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM.";
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000033; AAV42767.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_193798.1; -.
3D structure databases
ModBase Q5FKK7.
Enzyme and pathway databases
BioCyc LACI272621:LBA0910-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q5FKK7.
Genome annotation databases
GeneID 3251850; -.
GenomeReviews CP000033_GR; LBA0910.
KEGG lac:LBA0910; -.
NMPDR fig|272621.3.peg.903; -.
Phylogenomic databases
HOGENOM Q5FKK7; -.
Genome annotation databases
CMR Q5FKK7; LBA0910.
Other
ProtoNet Q5FKK7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   308  308     L-lactate dehydrogenase 2. PRO_0000237548
NP_BIND   11    39  29     NAD (By similarity). 
ACT_SITE   174   174        Proton acceptor. 
BINDING   87    87        Substrate (By similarity). 
BINDING   119   119        NAD or substrate (By similarity). 
BINDING   150   150        Substrate (By similarity). 
BINDING   224   224        Substrate (By similarity). 
Sequence information
Length: 308 AA [This is the length of the unprocessed precursor] Molecular weight: 33349 Da [This is the MW of the unprocessed precursor] CRC64: A9BC556A14F44E83 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSRKVFLVGD GAVGSTFAND LLQNTTVDEL AIFDVAKDRP VGDSMDLEDI TPFTGQTNIH 

        70         80         90        100        110        120 
PAEYSDAKDA DVCVITAGVP RKPGETRLDL VNKNVKILKT IVDPVVESGF KGVFVVSANP 

       130        140        150        160        170        180 
VDILTTLTQK ISGFPKDRVI GTGTSLDSMR LRVELAKKLN VPVAKVNSMV LGEHGDTSFE 

       190        200        210        220        230        240 
NFDESTVDNK PLRDYSEIND NVLSEIESDV RKKGGKIITN KGATFYGVAM MLTQIVSAIL 

       250        260        270        280        290        300 
DNRSICLPLS APINGEYGIK HDLYLGTPTI INGNGIEKVI ETKLSDVEKA KMINSADKMQ 


EVLSGVEM
Q5FKK7 in FASTA format

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