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UniProtKB/Swiss-Prot entry Q5FJB8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_LACAC
Primary accession number Q5FJB8
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on March 1, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 31)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: LBA1381
From
Lactobacillus acidophilus [TaxID: 1579] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCFM;
DOI=10.1073/pnas.0409188102; PubMed=15671160 [NCBI, ExPASy, EBI, Israel, Japan]
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.;
"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM.";
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000033; AAV43206.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_194237.1; -.
3D structure databases
ModBase Q5FJB8.
Protein family/group databases
MEROPS M38.972; -.
Enzyme and pathway databases
BioCyc LACI272621:LBA1381-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q5FJB8.
Genome annotation databases
GeneID 3252590; -.
GenomeReviews CP000033_GR; LBA1381.
KEGG lac:LBA1381; -.
NMPDR fig|272621.3.peg.1298; -.
Phylogenomic databases
HOGENOM Q5FJB8; -.
Genome annotation databases
CMR Q5FJB8; LBA1381.
Other
ProtoNet Q5FJB8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Dihydroorotase. PRO_1000024086
METAL   56    56        Zinc 1 (By similarity). 
METAL   58    58        Zinc 1 (By similarity). 
METAL   138   138        Zinc 1; via carbamate group (By similarity). 
METAL   138   138        Zinc 2; via carbamate group (By similarity). 
METAL   175   175        Zinc 2 (By similarity). 
METAL   228   228        Zinc 2 (By similarity). 
METAL   301   301        Zinc 1 (By similarity). 
MOD_RES   138   138        N6-carboxylysine (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 46392 Da [This is the MW of the unprocessed precursor] CRC64: B620B6A643E949B6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKTVIKNGTV YQNGRLIHAD VLIEDQKIKV IGTNLTGDKE FDATGKLVAP GLVDVHVHYR 

        70         80         90        100        110        120 
EPGQTYKEDI RTGSEAAARG GFTTVGAMPN VTPVPNTPEL MEKMVKKNQE KGIVHIFQYG 

       130        140        150        160        170        180 
PITNDETTDI IPDYAALKKA GAFALSNDGH GVQTAQTMYL AMQKAKANNL IIATHAQDDS 

       190        200        210        220        230        240 
LFNHGIVNEG KKAEELNLPP VTELAETTQI ARDLLLAQKT GVHYHICHVS TKTSVELVRM 

       250        260        270        280        290        300 
AKARGINVTC EVAPHHILLT DDDIPKDNGY YKMNPPLRNK EDQAALLVGL LDGTIDLIAT 

       310        320        330        340        350        360 
DHAPHAKKEK QGGMKGAAFG ITGSETAFST LYTKFVKKDK VFTLEQLLSW LSDKPAEAFG 

       370        380        390        400        410        420 
LKDAGVLEPG KNADIAIFDI EHEATIEEKD YKSKGVNTPF TGQKVYGETV MTMVNGKVVY 


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Q5FJB8 in FASTA format

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