FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBUNIT: Associates with DNA double-strand breaks (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Telomere (By similarity). Note=Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks (By similarity).
SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
SIMILARITY: Contains 1 FAT domain.
SIMILARITY: Contains 1 FATC domain.
SIMILARITY: Contains 1 PI3K/PI4K domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AACQ01000034; EAL00247.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AACQ01000033; EAL00369.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

XP_719142.1; -.
XP_719259.1; -.

3D structure databases

ModBase

Q5ABX0.

Organism-specific databases

CGD

CAL0006254; orf19.5580.

Family and domain databases

InterPro

IPR015519; Ataxia_Telang_Mut.
IPR003152; FATC.
IPR000403; PI3/4_kinase_cat.
IPR014009; PIK_FAT.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.1070.11; PI3/4_kinase_cat; 1.

PANTHER

PTHR11139:SF3; Ataxia_Telang_Mut; 1.

Pfam

PF02260; FATC; 1.
PF00454; PI3_PI4_kinase; 1.
Pfam graphical view of domain structure.

SMART

SM00146; PI3Kc; 1.
SMART graphical view of domain structure.

PROSITE

PS51189; FAT; 1.
PS51190; FATC; 1.
PS00915; PI3_4_KINASE_1; FALSE_NEG.
PS00916; PI3_4_KINASE_2; 1.
PS50290; PI3_4_KINASE_3; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q5ABX0.

Genome annotation databases

GeneID

3639073; -.
3639263; -.

KEGG

cal:CaO19.13026; -.
cal:CaO19.5580; -.

Other

ProtoNet

Q5ABX0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Chromatin regulator; Chromosomal protein; DNA damage; DNA repair; Kinase; Nucleus; Serine/threonine-protein kinase; Telomere; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 2873`	`2873`	`Serine/threonine-protein kinase TEL1.`	`PRO_0000227698`
`DOMAIN`	`1830 2425`	`596`	`FAT.`
`DOMAIN`	`2556 2873`	`318`	`PI3K/PI4K.`
`DOMAIN`	`2841 2873`	`33`	`FATC.`
`VARIANT`	`1158 1158`	`1`	`P -> S (in allele CaO19.13026).`
`VARIANT`	`1231 1231`	`1`	`K -> R (in allele CaO19.13026).`
`VARIANT`	`1324 1324`	`1`	`L -> V (in allele CaO19.13026).`

Sequence information

Length: 2873 AA [This is the length of the unprocessed precursor]

Molecular weight: 327927 Da [This is the MW of the unprocessed precursor]

CRC64: 8F939ADBAB0F9ADA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSTSDINKTI ALLQSSKIKE RNDALNNLEN IAASKFRLNP KQFRQLTQAI LALIKHESQI 

        70         80         90        100        110        120 
YFNNKSTTVD SRLSQASYNL RLLTEKSIED TRIDFKYRTY LDLCMGIKDQ FFVHSELLEP 

       130        140        150        160        170        180 
CSIDFIKTIT SILNLSYVKE HLNRKEWSIL YIFLVSLINN ILDDCEGSFS NNGNNEKLLI 

       190        200        210        220        230        240 
DLYTALQNLL QCESSVSINY LQLYDNDNYF KLLRILDKTS ELLKKENVII IIIFRIINKL 

       250        260        270        280        290        300 
ITVIATEKFK FVNKLIKIGI RLMVYFHHSH WEKLQEQFLI FINLPGTHDL INLHNLPKLI 

       310        320        330        340        350        360 
GDRYILSEIS TQEDGDSINS QADNQDEVFL YNLGVLIHHL MKKLMSGSFE LKTEDIGMCT 

       370        380        390        400        410        420 
INNSITWFNL KTIYSDSQNY KPWLLTLGVS RLLKSYYDLK QFINKQSNDL QTSLLLYSNG 

       430        440        450        460        470        480 
SPNKNKRQKL GSIADTISDS NSAIELCNKL IHSKESSDNQ VLGLKLLTFY LELYTFEKPK 

       490        500        510        520        530        540 
EQSTESDSMD TTIGENTTFD FVISTTDNTF IDKNVVMKNI LITFDDNSMN FWSSLCARSV 

       550        560        570        580        590        600 
LLDEILQSNH GGFKFKKSFS IQLLKLSLLL LKEPEVANIA CNIIFKLVFE QKTNLSELID 

       610        620        630        640        650        660 
DSVIIQLETL IDLSEINGPY KITEESFQFW YAINKLAIEV NLSKKNFLGR RIQDWMLAKW 

       670        680        690        700        710        720 
DITFSPGADF VSVGSSLANF MYWLSGNSIS YSPTTTQKST YEGDIYEFYY FAQSYDSLEK 

       730        740        750        760        770        780 
FLCLKSVSDS SETIKFDIIS IASSDRIDAI LNKVNSTFMV FDRSSVTSGS LFCWIIVLSN 

       790        800        810        820        830        840 
IVAKVRSMKF VTHELTGLQF QLSAGLNSFK DITLSCEEII DVMEMVNKFL PTDPDTIQIF 

       850        860        870        880        890        900 
IQNFPSEKLV NIIKFDYPGL ADKDNRKSVP EDGFGWEFSR VRDATTPPST TSTSTISLAK 

       910        920        930        940        950        960 
LNYKKIQSLE VSKFIMFTAD IEGKLQSDIL TAFLNYVETL GTDDFLPSLL FVVENIFTDH 

       970        980        990       1000       1010       1020 
SAHFIDEIQL AKLLRIINEK LLSTQNYERN EFVLVVISRF LSATAQVWIN SSDNSLASDF 

      1030       1040       1050       1060       1070       1080 
YSLVSRLYSS GRDDLILTET SIVEYCRFLA HFITHNDERV LSNTDIKNEL LEKFSKSPNN 

      1090       1100       1110       1120       1130       1140 
IKDRLANSFG ELVSLSTVQQ QGQIYSDLFD RFVNPEQSVE SAGTYTKFFT NLSQSSLHIL 

      1150       1160       1170       1180       1190       1200 
RLALFNLLEC SRFPFFIPYL EICLKEFCMI MKLDNANKLF KIFKFEILRN WWKYDSIDAF 

      1210       1220       1230       1240       1250       1260 
PFVLFSYTDL SSFYRDNYRE LIAVALSTKS KSPEISNAFV EQLADLKQSH SETLVAESLS 

      1270       1280       1290       1300       1310       1320 
IIVPLSYSKD GVRNDVFQIL LDYLKNSFKQ EFIDKLPLIV LEIIKFTEIS NEKSFESLGT 

      1330       1340       1350       1360       1370       1380 
DGLLTMLLND TGFSSTIQTA GEMVISFDSS VQLLKKLVEK YHQPEHETFW SSRQIYFLIR 

      1390       1400       1410       1420       1430       1440 
RLSISLKLAT TFEQKVIFLR KFKFVLVLGG KKSIDYAVSR LLVDTLCPLL SNEPKMSADV 

      1450       1460       1470       1480       1490       1500 
FLILQSLTDV YSHRYTYDKS ISLIIQIINS LLETEAVDRS RALLDCIDDF VNTGDQDRAI 

      1510       1520       1530       1540       1550       1560 
CQLLKSSVAI LKGQAVEIES SLIELCLEES GPDYIKQMIL ISRIFGNVVF ATTHSGSKLP 

      1570       1580       1590       1600       1610       1620 
VVEKLLALSK NQIQEFSDGY KLWIANYLSD FYIEGGCKEQ IKALTFDEYE GIPVNDFENE 

      1630       1640       1650       1660       1670       1680 
VRSFDFTLKS IEQYIYKDDF EAAACAESII GVLIRKYETS KREVSKFLNF ETTLEKHSDS 

      1690       1700       1710       1720       1730       1740 
ILPIDFHTCV ILNDKADVEY LGDELIDIIN NFESFLSNGT ELWCTKLYLA LLQELAVETS 

      1750       1760       1770       1780       1790       1800 
IAPLLSTFVI MVPEFAKTSL PVLVCNYLAI KRTHSQDRII SLLNEFLHTS KKSESSIKVF 

      1810       1820       1830       1840       1850       1860 
LQILILIRVG AKIFKKPVFA NVFAKIDKLK FYQLACEVKQ FKTALMLFED VASDTNSDVH 

      1870       1880       1890       1900       1910       1920 
LQDHYQTLQH VYESLDDDDL VFGLPERTTL EYSISMINRV GNSDDRLRFS SAGFDTDMIL 

      1930       1940       1950       1960       1970       1980 
NQEPSYSNIV GSLSAAGLLG VSRALSKNTS FASNDDSQYE WSWKLSKWDL PISKNATKEN 

      1990       2000       2010       2020       2030       2040 
EVIYKTLKQI HDFPMNSQDI CSSSLLNAVD NKVSATNMSV KEFKQEGINW LKTISTVASI 

      2050       2060       2070       2080       2090       2100 
AEIANATGDN IIPMTNQFSE KTQWFGEVEF SMFENLLLAR QTTFGLINDR PISSLPSDTA 

      2110       2120       2130       2140       2150       2160 
WMGALCDLVR YNNLARTNGE YQKMVTSTML VDVVSKKLQS SSLDMVAFNA NNLASFQTAQ 

      2170       2180       2190       2200       2210       2220 
TLWCQGNTNV PVMIMKDLYA AGGIDMSENI LKVDKCLIRA MMVDWMSQSR QEVASSIMEK 

      2230       2240       2250       2260       2270       2280 
YVMPTEELSN HMIDLQQQSK IFSILARFCE EQYKSKSLSE KISKLEKRVL NKENEIKDLK 

      2290       2300       2310       2320       2330       2340 
KQYEKVTVTH AEQKQVQQYY NRLKKQFVSE SKDLESLRKS KQLFSSKAVQ YYMKSIIVDD 

      2350       2360       2370       2380       2390       2400 
FEEENLDKFF SLWLEQSGNN ELNQSIQSDL LALPSYKLVS WCTQLISRLS NETNNFQILL 

      2410       2420       2430       2440       2450       2460 
KKLIINMCLD HPHHSLYLLL SLKKHKPNTN EVLNPSLLSR CAAAQAIWDQ LLLQDHRYVS 

      2470       2480       2490       2500       2510       2520 
GVLLPIDGFT DQCITLAAYK VSKGKSIDLT KFSAGDYWLN ELPAIPPPTE TIRVDPSKQY 

      2530       2540       2550       2560       2570       2580 
KNVPVLHSID KKISIATSGL SLPKIANFIL SNGTEHRVLL KHGTDGIRQD SIMEQVFNKV 

      2590       2600       2610       2620       2630       2640 
NNIFAKDREC NKRGLTIRTY NAVPLGPLSG IIEFVPNSMA FIDVISGYHQ IHDKISYDKA 

      2650       2660       2670       2680       2690       2700 
REMMKSCQSG DKQKRIHSFE QIEAKIKPVM RYFFQETFLT SDSWFESRVK YTHGIATSSI 

      2710       2720       2730       2740       2750       2760 
VGHILGLGDR HCNNILIDRS TGEPIHIDLG VAFDQGKRLA IPETVPFRLT RDIVDGFGVT 

      2770       2780       2790       2800       2810       2820 
GVEGMFKKSC EHTLRVLRTN KEHIISILDV LRWDPLYSWT LSRFKKRKLQ EDETGPGVQP 

      2830       2840       2850       2860       2870 
EEEGSEAGTA IMTVIEKLNA NGLSTEAAVR ELIQEATSTQ NLALIYFGWS PFY

Q5ABX0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools