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UniProtKB/Swiss-Prot entry Q59TD3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MED8_CANAL
Primary accession number Q59TD3
Secondary accession number Q59TG7
Integrated into Swiss-Prot on September 11, 2007
Sequence was last modified on April 26, 2005 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 18)
Name and origin of the protein
Protein name Mediator of RNA polymerase II transcription subunit 8
Synonym Mediator complex subunit 8
Gene name
Name: MED8
ORFNames: CaO19.4497, CaO19.11973
From
Candida albicans (Yeast) [TaxID: 5476] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314;
DOI=10.1073/pnas.0401648101; PubMed=15123810 [NCBI, ExPASy, EBI, Israel, Japan]
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
Comments
  • FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
  • SUBUNIT: Component of the Mediator complex (By similarity).
  • SUBCELLULAR LOCATION: Nucleus (Probable).
  • SIMILARITY: Belongs to the Mediator complex subunit 8 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AACQ01000142; EAK93723.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AACQ01000141; EAK93757.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_712891.1; -.
XP_712923.1; -.
3D structure databases
ModBase Q59TD3.
Organism-specific databases
CGD CAL0079252; MED8.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Genome annotation databases
GeneID 3645446; -.
3645495; -.
KEGG cal:CaO19.11973; -.
cal:CaO19.4497; -.
Phylogenomic databases
OMA Q59TD3; LPEVDEW.
Other
ProtoNet Q59TD3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Activator; Coiled coil; Nucleus; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   239  239     Mediator of RNA polymerase II transcription subunit 8. PRO_0000304538
COILED   30    59  30     Potential. 
VARIANT   121   121  1     R -> K (in allele CaO19.4497). 
Sequence information
Length: 239 AA [This is the length of the unprocessed precursor] Molecular weight: 27959 Da [This is the MW of the unprocessed precursor] CRC64: EFDF7C7331CBB019 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSQTPFNPNS PSVPTTTSLP STDFSQIPYD VLESIRNRLN QIRQSLTKLA DQINNHNRHP 

        70         80         90        100        110        120 
QKIKLPSYSY FQNQFQVLIT QLMSITNQLY NNEDLLRNTN VYPTPIFPTS AHENMLTTLL 

       130        140        150        160        170        180 
RKKVAPEVDE WINGAKLIME NETKNKLDNQ QVEIDILKID QWVQWCLAKI QDLRDEFQFY 

       190        200        210        220        230 
GFHTVEELDH METPQGKQEI KEKKDKEFER EQIELKITAG GQKSLHPNQV LKFMCQGQI 

Q59TD3 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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