[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 25975; Desgagnes R., Gagnon G., Frenette M.; Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Isocitrate + NADP⁺ = 2-oxoglutarate + CO₂ + NADPH.
CATALYTIC ACTIVITY: Oxalosuccinate + NADP⁺ = 2-oxoglutarate + CO₂ + NADPH.
COFACTOR: Binds 1 magnesium or manganese ion per subunit (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L14780; AAA98355.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P39126; 1HQS. [HSSP ENTRY / PDB]

ModBase

Q59985.

Family and domain databases

InterPro

IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.718.10; IDH_IMDH; 1.

PANTHER

PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.

Pfam

PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00470; IDH_IMDH; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 391`	`391`	`Isocitrate dehydrogenase [NADP].`	`PRO_0000083569`
`METAL`	`283 283`		`Magnesium or manganese (By similarity).`
`BINDING`	`102 102`		`Substrate (By similarity).`
`BINDING`	`104 104`		`Substrate (By similarity).`
`BINDING`	`108 108`		`Substrate (By similarity).`
`BINDING`	`118 118`		`Substrate (By similarity).`
`BINDING`	`142 142`		`Substrate (By similarity).`
`SITE`	`149 149`	`1`	`Critical for catalysis (By similarity).`
`SITE`	`219 219`	`1`	`Critical for catalysis (By similarity).`
`MOD_RES`	`102 102`		`Phosphoserine (By similarity).`

Sequence information

Length: 391 AA [This is the length of the unprocessed precursor]

Molecular weight: 43201 Da [This is the MW of the unprocessed precursor]

CRC64: E9860E74D470ED3B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAEKIVMKNG QLQVSDRPII PFIEGDGVGH DIWKNAQAIF DKAVEVAYEG KRHIEWQELL 

        70         80         90        100        110        120 
AGKKAYDKTG EWLPKETLEA IRESLVAIKG PLETPVGGGI RSLNVALRQE LDLYACVRPV 

       130        140        150        160        170        180 
RYFDGVASPL KEPEKTNITI FRENTEDIYA GIEWEAGTAD VKRVIEFLQT EMNVNKIRFP 

       190        200        210        220        230        240 
ESSSIGIKPI SIEGSKRLIR SAIDYALKNN LKKVTLVHKG NIQKFTEGGF RKWGYEVAQE 

       250        260        270        280        290        300 
DYKEELLAGR LEINDIIADN FLQQILLNPE KFDVVALTNL NGDYASDALA AQVGGIGISP 

       310        320        330        340        350        360 
GANINYQTGH AIFEATHGTA PDIADQDKAN PCSVLLSGCM LLDYIGWTEA AQLITSAIEK 

       370        380        390 
TFKADIFTAD LAFGKQAYST SAFSNQILSI M

Q59985 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools