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UniProtKB/Swiss-Prot entry Q59385


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATCU_ECOLI
Primary accession number Q59385
Secondary accession numbers P78245 Q2MBU3
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on January 23, 2007 (Sequence version 4)
Annotations were last modified on    July 22, 2008 (Entry version 78)
Name and origin of the protein
Protein name Copper-transporting P-type ATPase
Synonym EC 3.6.3.4
Gene name
Name: copA
Synonyms: ybaR
OrderedLocusNames: b0484, JW0473
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
Das S., Chuang E., Vulpe C., Goldman J., Gitschier J.;
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
"Sequence of minutes 4-25 of Escherichia coli.";
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[5]
PROTEIN SEQUENCE OF 2-11.
STRAIN=K12;
DOI=10.1111/j.1574-6968.1998.tb13343.x; PubMed=9868784 [NCBI, ExPASy, EBI, Israel, Japan]
Wasinger V.C., Humphery-Smith I.;
"Small genes/gene-products in Escherichia coli K-12.";
FEMS Microbiol. Lett. 169:375-382(1998).
[6]
CHARACTERIZATION.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1073/pnas.97.2.652; PubMed=10639134 [NCBI, ExPASy, EBI, Israel, Japan]
Rensing C., Fan B., Sharma R., Mitra B., Rosen B.P.;
"CopA: an Escherichia coli Cu(I)-translocating P-type ATPase.";
Proc. Natl. Acad. Sci. U.S.A. 97:652-656(2000).
[7]
CHARACTERIZATION.
STRAIN=K12;
DOI=10.1016/S0378-1119(00)00509-6; PubMed=11167016 [NCBI, ExPASy, EBI, Israel, Japan]
Petersen C., Moeller L.B.;
"Control of copper homeostasis in Escherichia coli by a P-type ATPase, CopA, and a MerR-like transcriptional activator, CopR.";
Gene 261:289-298(2000).
[8]
MUTAGENESIS OF CYS-14; CYS-17; CYS-110 AND CYS-113.
DOI=10.1006/bbrc.2001.5367; PubMed=11500054 [NCBI, ExPASy, EBI, Israel, Japan]
Fan B., Grass G., Rensing C., Rosen B.P.;
"Escherichia coli CopA N-terminal Cys(X)(2)Cys motifs are not required for copper resistance or transport.";
Biochem. Biophys. Res. Commun. 286:414-418(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U58330; AAB02268.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U82664; AAB40238.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC73586.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAE76263.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C64779; C64779.
RefSeq AP_001133.1; -.
NP_415017.1; -.
3D structure databases
HSSP P04129; 1AFJ. [HSSP ENTRY / PDB]
ModBase Q59385.
Protein-protein interaction databases
IntAct Q59385; -.
Enzyme and pathway databases
BioCyc EcoCyc:G6260-MON; -.
Organism-specific databases
EchoBASE EB3035; -.
EcoGene EG13246; copA.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR006416; ATPase-IB_hvy.
IPR001757; ATPase_P.
IPR006403; ATPase_P_cat/Cu.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR000695; H_ATPase.
IPR006121; HeavyMe_transpt.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00122; E1-E2_ATPase; 1.
PF00403; HMA; 2.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00120; HATPASE.
TIGRFAMs TIGR01511; ATPase-IB1_Cu; 1.
TIGR01525; ATPase-IB_hvy; 1.
TIGR01494; ATPase_P-type; 2.
PROSITE PS00154; ATPASE_E1_E2; 1.
PS01047; HMA_1; 1.
PS50846; HMA_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q59385.
Genome annotation databases
GeneID 946106; -.
GenomeReviews U00096_GR; b0484.
AP009048_GR; JW0473.
KEGG ecj:JW0473; -.
eco:b0484; -.
Phylogenomic databases
HOGENOM Q59385; -.
Genome annotation databases
CMR Q59385; b0484.
Other
ProtoNet Q59385.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell membrane; Complete proteome; Copper; Copper transport; Direct protein sequencing; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   834  833     Copper-transporting P-type ATPase. PRO_0000046320
TRANSMEM   187   207  21     Potential. 
TRANSMEM   218   238  21     Potential. 
TRANSMEM   254   274  21     Potential. 
TRANSMEM   284   304  21     Potential. 
TRANSMEM   438   458  21     Potential. 
TRANSMEM   464   484  21     Potential. 
TRANSMEM   779   799  21     Potential. 
TRANSMEM   801   821  21     Potential. 
DOMAIN   4    65  62     HMA 1. 
DOMAIN   100   163  64     HMA 2. 
ACT_SITE   523   523        4-aspartylphosphate intermediate (Probable). 
METAL   14    14        Copper (Potential). 
METAL   17    17        Copper (Potential). 
METAL   110   110        Copper (Potential). 
METAL   113   113        Copper (Potential). 
METAL   720   720        Magnesium (By similarity). 
METAL   724   724        Magnesium (By similarity). 
MUTAGEN   8   150        Missing: Loss of activity. 
MUTAGEN   14    14        C->A: No effect. 
MUTAGEN   17    17        C->A: No effect. 
MUTAGEN   110   110        C->A: No effect. 
MUTAGEN   113   113        C->A: No effect. 
CONFLICT   162   181        EAIEDDAKRRERQQETAVAT -> KRLKMTLNAASASKKPPSLA (in Ref. 1; AAB02268). 
CONFLICT   508   508        A -> R (in Ref. 1; AAB02268). 
CONFLICT   576   576        Q -> R (in Ref. 1; AAB02268). 
Sequence information
Length: 834 AA [This is the length of the unprocessed precursor] Molecular weight: 87873 Da [This is the MW of the unprocessed precursor] CRC64: CF84A18FE208E6F6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSQTIDLTLD GLSCGHCVKR VKESLEQRPD VEQADVSITE AHVTGTASAE QLIETIKQAG 

        70         80         90        100        110        120 
YDASVSHPKA KPLAESSIPS EALTAVSEAL PAATADDDDS QQLLLSGMSC ASCVTRVQNA 

       130        140        150        160        170        180 
LQSVPGVTQA RVNLAERTAL VMGSASPQDL VQAVEKAGYG AEAIEDDAKR RERQQETAVA 

       190        200        210        220        230        240 
TMKRFRWQAI VALAVGIPVM VWGMIGDNMM VTADNRSLWL VIGLITLAVM VFAGGHFYRS 

       250        260        270        280        290        300 
AWKSLLNGAA TMDTLVALGT GVAWLYSMSV NLWPQWFPME ARHLYYEASA MIIGLINLGH 

       310        320        330        340        350        360 
MLEARARQRS SKALEKLLDL TPPTARLVTD EGEKSVPLAE VQPGMLLRLT TGDRVPVDGE 

       370        380        390        400        410        420 
ITQGEAWLDE AMLTGEPIPQ QKGEGDSVHA GTVVQDGSVL FRASAVGSHT TLSRIIRMVR 

       430        440        450        460        470        480 
QAQSSKPEIG QLADKISAVF VPVVVVIALV SAAIWYFFGP APQIVYTLVI ATTVLIIACP 

       490        500        510        520        530        540 
CALGLATPMS IISGVGRAAE FGVLVRDADA LQRASTLDTV VFDKTGTLTE GKPQVVAVKT 

       550        560        570        580        590        600 
FADVDEAQAL RLAAALEQGS SHPLARAILD KAGDMQLPQV NGFRTLRGLG VSGEAEGHAL 

       610        620        630        640        650        660 
LLGNQALLNE QQVGTKAIEA EITAQASQGA TPVLLAVDGK AVALLAVRDP LRSDSVAALQ 

       670        680        690        700        710        720 
RLHKAGYRLV MLTGDNPTTA NAIAKEAGID EVIAGVLPDG KAEAIKHLQS EGRQVAMVGD 

       730        740        750        760        770        780 
GINDAPALAQ ADVGIAMGGG SDVAIETAAI TLMRHSLMGV ADALAISRAT LHNMKQNLLG 

       790        800        810        820        830 
AFIYNSIGIP VAAGILWPFT GTLLNPVVAG AAMALSSITV VSNANRLLRF KPKE 

Q59385 in FASTA format

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