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UniProtKB/Swiss-Prot entry Q58997


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_METJA
Primary accession number Q58997
Secondary accession numbers None
Integrated into Swiss-Prot on July 11, 2003
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 49)
Name and origin of the protein
Protein name Homoserine dehydrogenase
Synonyms HDH
EC 1.1.1.3
Gene name
Name: hom
OrderedLocusNames: MJ1602
From
Methanocaldococcus jannaschii (Methanococcus jannaschii) [TaxID: 2190] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
PubMed=8688087 [NCBI, ExPASy, EBI, Israel, Japan]
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.";
Science 273:1058-1073(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L77117; AAB99622.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A64500; A64500.
RefSeq NP_248612.1; -.
3D structure databases
ModBase Q58997.
Enzyme and pathway databases
BioCyc MJAN243232:MJ_1602-MON; -.
Family and domain databases
InterPro IPR005106; Asp/hSer_DHase_NAD-bd.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.
Pfam PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS Q58997.
Genome annotation databases
GeneID 1452511; -.
GenomeReviews L77117_GR; MJ1602.
KEGG mja:MJ1602; -.
NMPDR fig|243232.1.peg.1649; -.
TIGR MJ1602; -.
Phylogenomic databases
HOGENOM Q58997; -.
Other
ProtoNet Q58997.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   336  336     Homoserine dehydrogenase. PRO_0000066705
NP_BIND   6    13  8     NADP (By similarity). 
ACT_SITE   223   223        Proton donor (Potential). 
BINDING   94    94        NADP (By similarity). 
BINDING   123   123        NADP (By similarity). 
BINDING   208   208        Substrate (By similarity). 
Sequence information
Length: 336 AA [This is the length of the unprocessed precursor] Molecular weight: 36462 Da [This is the MW of the unprocessed precursor] CRC64: EDAEFA1998439B48 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDIIIVGFGA IGKGIAKVLY DKKDYLKKNY EEFKVVAITD SSGAAIDEDG LDLLKAIEVK 

        70         80         90        100        110        120 
EKTGKIKNYP EKGREMSSID VIKEVDADVV VEVTPSNLET GDPAKTHILE SFKNKKHVVT 

       130        140        150        160        170        180 
ANKGPLALCY KELIEEAKKH GVIFRHEASV GGAMPIINLA KETLAGNEIL SIRGILNGTT 

       190        200        210        220        230        240 
NYILTKMEKE GLDFETALKE AKELGIAETD PTQDIEGLDT AAKIVILANS IMGMNKTIKD 

       250        260        270        280        290        300 
VKVKGISRIT PEALFLANKR GYTIKLIGQI KDGYLIVEPM LVPIDSPLNV KGTLNVAMFE 

       310        320        330 
TDLAKEVVVV GRGAGPIETA SAILSDLIHI YNSTKK 

Q58997 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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