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UniProtKB/Swiss-Prot entry Q56313

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RUVB_THEMA
Primary accession number Q56313
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 66)
Name and origin of the protein
Protein name Holliday junction ATP-dependent DNA helicase ruvB
Synonym EC 3.6.1.-
Gene name
Name: ruvB
OrderedLocusNames: TM_1730
From
Thermotoga maritima [TaxID: 2336] [HAMAP proteome]
Taxonomy Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8626340 [NCBI, ExPASy, EBI, Israel, Japan]
Tong J., Wetmur J.G.;
"Cloning, sequencing, and expression of ruvB and characterization of RuvB proteins from two distantly related thermophilic eubacteria.";
J. Bacteriol. 178:2695-2700(1996).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43589 / MSB8 / DSM 3109 / JCM 10099;
DOI=10.1038/20601; PubMed=10360571 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.;
"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.";
Nature 399:323-329(1999).
Comments
  • FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity).
  • SUBUNIT: Forms a complex with ruvA.
  • SIMILARITY: Belongs to the ruvB family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U38840; AAB03727.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000512; AAD36795.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A72217; A72217.
RefSeq NP_229528.1; -.
3D structure databases
PDB
1IN4; X-ray; 1.60 A; A=1-334.[ExPASy / RCSB / EBI]
1IN5; X-ray; 2.00 A; A=1-334.[ExPASy / RCSB / EBI]
1IN6; X-ray; 1.80 A; A=1-334.[ExPASy / RCSB / EBI]
1IN7; X-ray; 1.90 A; A=1-334.[ExPASy / RCSB / EBI]
1IN8; X-ray; 1.90 A; A=1-334.[ExPASy / RCSB / EBI]
1J7K; X-ray; 1.80 A; A=1-334.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1IN4; -.
1IN5; -.
1IN6; -.
1IN7; -.
1IN8; -.
1J7K; -.
ModBase Q56313.
Enzyme and pathway databases
BioCyc TMAR243274:TM_1730-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0009378; Molecular function: four-way junction helicase activity (inferred from electronic annotation from HAMAP).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from HAMAP).
GO:0006281; Biological process: DNA repair (inferred from electronic annotation from HAMAP).
GO:0009432; Biological process: SOS response (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00016; -; 1.
PBIL [Tree]
InterPro IPR003593; AAA+_ATPase_core.
IPR003959; AAA_ATPase_core.
IPR000767; Disease_R.
IPR004605; DNA_helicase_Holl-junc_RuvB.
IPR008823; DNA_helicase_Holl-junc_RuvB_C.
IPR008824; DNA_helicase_Holl-junc_RuvB_N.
IPR011991; Wing_hlx_DNA_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
Pfam PF00004; AAA; 1.
PF05491; RuvB_C; 1.
PF05496; RuvB_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00364; DISEASERSIST.
SMART SM00382; AAA; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00635; ruvB; 1.
BLOCKS Q56313.
Genome annotation databases
GeneID 897204; -.
GenomeReviews AE000512_GR; TM_1730.
KEGG tma:TM1730; -.
NMPDR fig|243274.1.peg.1712; -.
TIGR TM_1730; -.
Phylogenomic databases
HOGENOM Q56313; -.
Other
ProtoNet Q56313.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   334  334     Holliday junction ATP-dependent DNA helicase ruvB. PRO_0000165617
NP_BIND   58    65  8     ATP (Potential). 
HELIX   24    26  3      
HELIX   31    47  17      
STRAND   54    59  6      
HELIX   64    75  12      
STRAND   79    83  5      
TURN   84    86  3      
HELIX   90    99  10      
STRAND   105   109  5      
HELIX   111   113  3      
HELIX   116   127  12      
STRAND   152   158  7      
HELIX   160   162  3      
HELIX   165   168  4      
STRAND   172   176  5      
HELIX   182   195  14      
HELIX   202   210  9      
HELIX   216   233  18      
STRAND   236   238  3      
HELIX   240   250  11      
HELIX   259   271  13      
HELIX   279   286  8      
HELIX   290   296  7      
HELIX   298   303  6      
STRAND   306   310  5      
STRAND   313   316  4      
HELIX   318   323  6      
Sequence information
Length: 334 AA [This is the length of the unprocessed precursor] Molecular weight: 37156 Da [This is the MW of the unprocessed precursor] CRC64: 6F4BBFBFA7B9C7A9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSEFLTPERT VYDSGVQFLR PKSLDEFIGQ ENVKKKLSLA LEAAKMRGEV LDHVLLAGPP 

        70         80         90        100        110        120 
GLGKTTLAHI IASELQTNIH VTSGPVLVKQ GDMAAILTSL ERGDVLFIDE IHRLNKAVEE 

       130        140        150        160        170        180 
LLYSAIEDFQ IDIMIGKGPS AKSIRIDIQP FTLVGATTRS GLLSSPLRSR FGIILELDFY 

       190        200        210        220        230        240 
TVKELKEIIK RAASLMDVEI EDAAAEMIAK RSRGTPRIAI RLTKRVRDML TVVKADRINT 

       250        260        270        280        290        300 
DIVLKTMEVL NIDDEGLDEF DRKILKTIIE IYRGGPVGLN ALAASLGVEA DTLSEVYEPY 

       310        320        330 
LLQAGFLART PRGRIVTEKA YKHLKYEVPE NRLF
Q56313 in FASTA format

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