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UniProtKB/Swiss-Prot entry Q54NZ7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALRB_DICDI
Primary accession number Q54NZ7
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on May 2, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 20)
Name and origin of the protein
Protein name Aldose reductase B
Synonyms ARB
EC 1.1.1.21
Aldehyde reductase B
Gene name
Name: alrB
ORFNames: DDB_0231282
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000073; EAL64990.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_639920.2; -.
3D structure databases
ModBase Q54NZ7.
Organism-specific databases
dictyBase DDB0231282; alrB.
Ontologies
GO
GO:0004032; Molecular function: aldehyde reductase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001395; Aldo/ket_red.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.100; Aldo/ket_red; 1.
PANTHER PTHR11732; Aldo/ket_red; 1.
Pfam PF00248; Aldo_ket_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00069; ALDKETRDTASE.
ProDom PD000288; Aldo/ket_red; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00798; ALDOKETO_REDUCTASE_1; 1.
PS00062; ALDOKETO_REDUCTASE_2; 1.
PS00063; ALDOKETO_REDUCTASE_3; 1.
BLOCKS Q54NZ7.
Genome annotation databases
GeneID 3391092; -.
KEGG ddi:DDB_0231282; -.
Other
ProtoNet Q54NZ7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   311  311     Aldose reductase B. PRO_0000327646
NP_BIND   13    23  11     NADP (Potential). 
NP_BIND   219   273  55     NADP (By similarity). 
ACT_SITE   54    54        Proton donor (By similarity). 
BINDING   116   116        Substrate (By similarity). 
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 35060 Da [This is the MW of the unprocessed precursor] CRC64: F60EBB244639962D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSQPQNTFKL NDDIHHIPMI GLGTYNGAKV GEVGDAVKVA LKSGYRHIDG AAIYMNEKEI 

        70         80         90        100        110        120 
GHALKEVFAE GEIKREDIFY VSKLWNSCHH ASLVRKHCEK TLEDLGLEYL DLYLIHWPIA 

       130        140        150        160        170        180 
FENADPSGTT TQPLRDSDGE PVLAAVSIRE TWQEMEKLVE YGLVKSIGVS NFNVQNLVDL 

       190        200        210        220        230        240 
LTYAKIKPAI NQVEVHPYLS QPNLKYFCDR YGIVLTAYSP LGQGKCDLLS NETLKSIADK 

       250        260        270        280        290        300 
HNKTVANVIF KWLNQRGIVT IPKSSNPARI IENFNIFDFQ LSNEDMDKIN SLNSNLRTCT 

       310 
PANFCKIPLF D 

Q54NZ7 in FASTA format

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