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UniProtKB/Swiss-Prot entry Q54D04


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDHB_DICDI
Primary accession number Q54D04
Secondary accession numbers None
Integrated into Swiss-Prot on December 4, 2007
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 29)
Name and origin of the protein
Protein name Probable malate dehydrogenase 2, mitochondrial [Precursor]
Synonym EC 1.1.1.37
Gene name
Name: mdhB
ORFNames: DDB_0230188
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000194; EAL61103.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_629516.1; -.
3D structure databases
ModBase Q54D04.
Organism-specific databases
dictyBase DDB0230188; mdhB.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
BLOCKS Q54D04.
Genome annotation databases
GeneID 3386244; -.
KEGG ddi:DDB_0230188; -.
Other
ProtoNet Q54D04.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     9  9     Mitochondrion (Potential). 
CHAIN   10   348  339     Probable malate dehydrogenase 2, mitochondrial. PRO_0000312348
NP_BIND   31    37  7     NAD (By similarity). 
NP_BIND   150   152  3     NAD (By similarity). 
ACT_SITE   208   208        Proton acceptor (By similarity). 
BINDING   112   112        Substrate (By similarity). 
BINDING   118   118        Substrate (By similarity). 
BINDING   125   125        NAD (By similarity). 
BINDING   132   132        NAD (By similarity). 
BINDING   152   152        Substrate (By similarity). 
BINDING   183   183        Substrate (By similarity). 
Sequence information
Length: 348 AA [This is the length of the unprocessed precursor] Molecular weight: 37648 Da [This is the MW of the unprocessed precursor] CRC64: A70092840B76C58B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNKILTRSFS TGANFFASGK GKAPVRVAIT GASGQIGYQL LFRIASGDML GKDQPIILQC 

        70         80         90        100        110        120 
LELPGAMNSL KGVSMELDDC AFPLLKGIVQ SDKPEEAFAG ADYALLVGAR PRSKGMERGD 

       130        140        150        160        170        180 
LLKANAEIFS VQGKALDKSA NRDTLRVLVV GNPANTNALI AARNAPNIDP KRFSAMTRLD 

       190        200        210        220        230        240 
HNRGLAQLAD KTGSAVTDIE KFCIWGNHSA TQYPDINFGT VKGKSLVDTI NDQKWVKDNF 

       250        260        270        280        290        300 
IPTVQQRGAA IIAARGLSSA ASAASAAIDH MRDWTYGTNG QWTSMAIYSE GEYGADKGLY 

       310        320        330        340 
FSFPVIVDNK GKYEIVKGLK LDQFSQERFD ATRKELLSEM DGVKELLP 

Q54D04 in FASTA format

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