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UniProtKB/Swiss-Prot entry Q53GI3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ZN394_HUMAN
Primary accession number Q53GI3
Secondary accession numbers Q6P5X9 Q8TB27 Q9HA37
Integrated into Swiss-Prot on November 8, 2005
Sequence was last modified on November 8, 2005 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 40)
Name and origin of the protein
Protein name Zinc finger protein 394
Synonym Zinc finger protein with KRAB and SCAN domains 14
Gene name
Name: ZNF394
Synonyms: ZKSCAN14
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/j.bbrc.2004.06.080; PubMed=15249231 [NCBI, ExPASy, EBI, Israel, Japan]
Huang C., Wang Y., Li D., Li Y., Luo J., Yuan W., Ou Y., Zhu C., Zhang Y., Wang Z., Liu M., Wu X.;
"Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394.";
Biochem. Biophys. Res. Commun. 320:1298-1305(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY642122; AAT67053.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK022360; BAB14021.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222948; BAD96668.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC025241; AAH25241.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051847; AAH51847.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00550333; -.
RefSeq NP_115540.2; -.
UniGene Hs.386324
3D structure databases
HSSP P08045; 1ZNF. [HSSP ENTRY / PDB]
ModBase Q53GI3.
Organism-specific databases
GeneCards GC07M098928; -.
HGNC HGNC:18832; ZNF394.
GenAtlas ZNF394.
PharmGKB PA38702; -.
Gene expression databases
ArrayExpress Q53GI3; -.
Bgee Q53GI3; -.
CleanEx HS_ZNF394; -.
GermOnline ENSG00000160908; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003700; Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001909; Krueppel-associated_box.
IPR003309; Treg_SCAN.
IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 6.
Pfam PF01352; KRAB; 1.
PF02023; SCAN; 1.
PF00096; zf-C2H2; 7.
Pfam graphical view of domain structure.
ProDom PD000003; Znf_C2H2; 6.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00349; KRAB; 1.
SM00431; SCAN; 1.
SM00355; ZnF_C2H2; 7.
SMART graphical view of domain structure.
PROSITE PS50805; KRAB; 1.
PS50804; SCAN_BOX; 1.
PS00028; ZINC_FINGER_C2H2_1; 6.
PS50157; ZINC_FINGER_C2H2_2; 7.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q53GI3; -.
Genome annotation databases
Ensembl ENSG00000160908; Homo sapiens. [Contig view]
GeneID 84124; -.
KEGG hsa:84124; -.
Phylogenomic databases
HOGENOM Q53GI3; -.
HOVERGEN Q53GI3; -.
OMA Q53GI3; THEDRVE.
Other
NextBio 73385; -.
ProtoNet Q53GI3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
DNA-binding; Metal-binding; Nucleus; Polymorphism; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   561  561     Zinc finger protein 394. PRO_0000047557
DOMAIN   64   146  83     SCAN box. 
DOMAIN   155   230  76     KRAB. 
ZN_FING   358   380  23     C2H2-type 1. 
ZN_FING   386   408  23     C2H2-type 2. 
ZN_FING   414   436  23     C2H2-type 3. 
ZN_FING   442   463  22     C2H2-type 4. 
ZN_FING   469   491  23     C2H2-type 5. 
ZN_FING   497   519  23     C2H2-type 6. 
ZN_FING   525   547  23     C2H2-type 7. 
VARIANT   325   325  1     T -> M (in dbSNP:rs3735454 [NCBI]). VAR_052816 
CONFLICT   3     3        S -> C (in Ref. 2; BAB14021). 
CONFLICT   21    21        M -> T (in Ref. 3; BAD96668). 
Sequence information
Length: 561 AA [This is the length of the unprocessed precursor] Molecular weight: 64256 Da [This is the MW of the unprocessed precursor] CRC64: D92AE5E58DEDAAA5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNSSLTAQRR GSDAELGPWV MAARSKDAAP SQRDGLLPVK VEEDSPGSWE PNYPAASPDP 

        70         80         90        100        110        120 
ETSRLHFRQL RYQEVAGPEE ALSRLRELCR RWLRPELLSK EQILELLVLE QFLTILPEEL 

       130        140        150        160        170        180 
QAWVREHCPE SGEEAVAVVR ALQRALDGTS SQGMVTFEDT AVSLTWEEWE RLDPARRDFC 

       190        200        210        220        230        240 
RESAQKDSGS TVPPSLESRV ENKELIPMQQ ILEEAEPQGQ LQEAFQGKRP LFSKCGSTHE 

       250        260        270        280        290        300 
DRVEKQSGDP LPLKLENSPE AEGLNSISDV NKNGSIEGED SKNNELQNSA RCSNLVLCQH 

       310        320        330        340        350        360 
IPKAERPTDS EEHGNKCKQS FHMVTWHVLK PHKSDSGDSF HHSSLFETQR QLHEERPYKC 

       370        380        390        400        410        420 
GNCGKSFKQR SDLFRHQRIH TGEKPYGCQE CGKSFSQSAA LTKHQRTHTG EKPYTCLKCG 

       430        440        450        460        470        480 
ERFRQNSHLN RHQSTHSRDK HFKCEECGET CHISNLFRHQ RLHKGERPYK CEECEKSFKQ 

       490        500        510        520        530        540 
RSDLFKHHRI HTGEKPYGCS VCGKRFNQSA TLIKHQRIHT GEKPYKCLEC GERFRQSTHL 

       550        560 
IRHQRIHQNK VLSAGRGGSR L 

Q53GI3 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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