Farnesyl pyrophosphate synthetase
     (FPP synthetase)
     (EC 2.5.1.1)
     (Dimethylallyltranstransferase)
Geranyltranstransferase
     (EC 2.5.1.10)

Gene name

Name:

idsA

From

Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133)

[TaxID: 79929]

Taxonomy

Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter.

Protein existence

1: Evidence at protein level;

References

[1]

NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
DOI=10.1006/abbi.1994.1459; PubMed=7979381 [NCBI, ExPASy, EBI, Israel, Japan]
Chen A., Poulter C.D.;
"Isolation and characterization of idsA: the gene for the short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum.";
Arch. Biochem. Biophys. 314:399-404(1994).

Comments

CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
COFACTOR: Magnesium.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the FPP/GGPP synthetase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

S75695; AAB32421.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q53479.

Family and domain databases

InterPro

IPR000092; Polyprenyl_synt.
IPR017446; Polyprenyl_synth-rel.
Graphical view of domain structure.

PANTHER

PTHR12001; Polyprenyl_synt; 1.

Pfam

PF00348; polyprenyl_synt; 1.
Pfam graphical view of domain structure.

PROSITE

PS00723; POLYPRENYL_SYNTHET_1; 1.
PS00444; POLYPRENYL_SYNTHET_2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Direct protein sequencing; Isoprene biosynthesis; Lipid synthesis; Magnesium; Multifunctional enzyme; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 325`	`324`	`Bifunctional short chain isoprenyl diphosphate synthase.`	`PRO_0000123972`

Sequence information

Length: 325 AA [This is the length of the unprocessed precursor]

Molecular weight: 35636 Da [This is the MW of the unprocessed precursor]

CRC64: D28CAFF56EBE27E9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTEVLDILRK YSEVADKRIM ECISDITPDT LLKASEHLIT AGGKKIRPSL ALLSCEAVGG 

        70         80         90        100        110        120 
NPEDAAGVAA AIELIHTFSL IHDDIMDDDE MRRGEPSVHV IWGEPMAILA GDVLFSKAFE 

       130        140        150        160        170        180 
AVIRNGDSER VKDALAVVVD SCVKICEGQA LDMGFEERLD VTEDEYMEMI YKKTAALIAA 

       190        200        210        220        230        240 
ATKAGAIMGG ASEREVEALE DYGKFIGLAF QIHDDYLDVV SDEESLGKPV GSDIAEGKMT 

       250        260        270        280        290        300 
LMVVKALEEA SEEDRERLIS ILGSGDEGSV AEAIEIFERY GATQYAHEVA LDYVRMAKER 

       310        320 
LEILEDSDAR DALMRIADFV LEREH

Q53479 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools