NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND FUNCTION.
STRAIN=Guyane 11;
DOI=10.1128/EC.00011-07; PubMed=17416896 [NCBI, ExPASy, EBI, Israel, Japan]
Liu X.-H., Lu J.-P., Zhang L., Dong B., Min H., Lin F.-C.;
"Involvement of a Magnaporthe grisea serine/threonine kinase gene, MgATG1, in appressorium turgor and pathogenesis.";
Eukaryot. Cell 6:997-1005(2007).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=70-15 / FGSC 8958;
DOI=10.1038/nature03449; PubMed=15846337 [NCBI, ExPASy, EBI, Israel, Japan]
Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
"The genome sequence of the rice blast fungus Magnaporthe grisea.";
Nature 434:980-986(2005).

Comments

FUNCTION: Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes. Autophagy is essential to fungal development, production of appressorium turgor, and pathogenicity in rice blast disease.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Uniformly detected in conidia, mycelia and appressoria (at protein level).
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ224381; ABB46201.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CH476833; EDK00687.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

XP_369878.1; -.

UniGene

Mgr.9939

3D structure databases

ModBase

Q52EB3.

Family and domain databases

InterPro

IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.

Pfam

PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00220; S_TKc; 1.
SMART graphical view of domain structure.

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q52EB3.

Genome annotation databases

GeneID

2684548; -.

KEGG

mgr:MGG_06393; -.

NMPDR

fig|242507.1.peg.10456; -.

Other

ProtoNet

Q52EB3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 982`	`982`	`Serine/threonine-protein kinase ATG1.`	`PRO_0000085648`
`DOMAIN`	`19 324`	`306`	`Protein kinase.`
`NP_BIND`	`25 33`	`9`	`ATP (By similarity).`
`ACT_SITE`	`162 162`		`Proton acceptor (By similarity).`
`BINDING`	`48 48`		`ATP (By similarity).`

Sequence information

Length: 982 AA [This is the length of the unprocessed precursor]

Molecular weight: 107443 Da [This is the MW of the unprocessed precursor]

CRC64: 9811E0BC78307638 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MADRSARRAR PGDDSVGQFV IGAEIGKGSF AQVYMGKHKV SGAAVAIKSV ELARLNKKLK 

        70         80         90        100        110        120 
ENLYGEINIL KTLRHPHIVA LHDCVESATH INLMMEYCEL GDLSLFIKKR EKLSTNPATH 

       130        140        150        160        170        180 
DMARKYPNVP NSGLNEVVIR HFLKQLSSAL KFLRESNLVH RDVKPQNLLL LPSPEFREVN 

       190        200        210        220        230        240 
KLARPILTAS QDSLVPVAGL ASLPMLKLAD FGFARVLPST SLAETLCGSP LYMAPEILRY 

       250        260        270        280        290        300 
ERYDAKADLW SVGTVLFEMI VGRPPFRASN HVELLRKIEA AEDVIKFPRE TTISSEMKGL 

       310        320        330        340        350        360 
TRALLKRNPV ERISFENFFA HPVIISSIPG LVEDDIPKPE ASEQRSSSKD TRAASKSDDP 

       370        380        390        400        410        420 
IASPRKYSFR RHPTDNDQIR DQFRRVEPPS SAAESAPSRQ TSAFSGIAAE ARKQAAAEAS 

       430        440        450        460        470        480 
ARTGQSSRNE PGDNLVPRRP QAQPSTSAPS KPGLYEERRR GISNASLNRS NRESSSPTSA 

       490        500        510        520        530        540 
ALANDSARAP PQQTSRRVQA EEREKAAQDV AFERDYVVVE KKHVEVNAFA DEMAANPRLG 

       550        560        570        580        590        600 
GQGTPLSPKS GQIVRRATQQ GNPTSTTGAI PAAPSRTMQI AQGTQRHYHE RGTSLSASPG 

       610        620        630        640        650        660 
STASFITKAI QDASLRLLGI KYPAGLTKGA SPPELYNPYP AYPTPSPPVG LISSGKQSTP 

       670        680        690        700        710        720 
VDEDARVAQL IEEHATRSDV VYGFAEVKYK QLVPLAPSAE HGLGGTTLED MPTGEEDVLT 

       730        740        750        760        770        780 
VEAIVSLSEE ALVLYVKALT LLAKSMDIAS LWWARKNRGD QANNALSSTR DSVNTQTLSL 

       790        800        810        820        830        840 
RINSAVQWVR SRFNEVLEKA EVVRLRLMDA QKRLPDDHPS HPSNHPQGSE SVNGASAEGV 

       850        860        870        880        890        900 
FLTVGVTAEK LMYDRALEMS RTAAINEITN EDLAGCEISY VTAIRMLEAV LDNDEDAPKR 

       910        920        930        940        950        960 
RLSANMDDSG GDGEDGHAEI NADDQQAVQK MIHMIRSRLT SVRSKVRMIS NASKAQQQSQ 

       970        980 
PQSLIRRRSG DVTPRSVPSY SS

Q52EB3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools