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UniProtKB/Swiss-Prot entry Q4WVM7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATM_ASPFU
Primary accession number Q4WVM7
Secondary accession numbers None
Integrated into Swiss-Prot on March 21, 2006
Sequence was last modified on March 21, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 31)
Name and origin of the protein
Protein name Serine/threonine-protein kinase tel1
Synonyms EC 2.7.11.1
DNA-damage checkpoint kinase tel1
Telomere length regulation protein 1
ATM homolog
Gene name
Name: tel1
ORFNames: AFUA_5G12660
From
Aspergillus fumigatus (Sartorya fumigata) [TaxID: 5085] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Af293 / CBS 101355 / FGSC A1100;
DOI=10.1038/nature04332; PubMed=16372009 [NCBI, ExPASy, EBI, Israel, Japan]
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.;
"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.";
Nature 438:1151-1156(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAHF01000003; EAL91349.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_753387.1; -.
3D structure databases
ModBase Q4WVM7.
Family and domain databases
InterPro IPR015519; Ataxia_Telang_Mut.
IPR003152; FATC.
IPR000403; PI3/4_kinase_cat.
IPR014009; PIK_FAT.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1070.11; PI3/4_kinase_cat; 1.
PANTHER PTHR11139:SF3; Ataxia_Telang_Mut; 1.
Pfam PF02260; FATC; 1.
PF00454; PI3_PI4_kinase; 1.
Pfam graphical view of domain structure.
SMART SM00146; PI3Kc; 1.
SMART graphical view of domain structure.
PROSITE PS51189; FAT; 1.
PS51190; FATC; 1.
PS00915; PI3_4_KINASE_1; 1.
PS00916; PI3_4_KINASE_2; 1.
PS50290; PI3_4_KINASE_3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q4WVM7.
Genome annotation databases
GeneID 3511168; -.
KEGG afm:AFUA_5G12660; -.
Phylogenomic databases
HOGENOM Q4WVM7; -.
Other
ProtoNet Q4WVM7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chromatin regulator; Chromosomal protein; Complete proteome; DNA damage; DNA repair; Kinase; Nucleus; Serine/threonine-protein kinase; Telomere; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   2796  2796     Serine/threonine-protein kinase tel1. PRO_0000227696
DOMAIN   1740   2337  598     FAT. 
DOMAIN   2467   2796  330     PI3K/PI4K. 
DOMAIN   2764   2796  33     FATC. 
Sequence information
Length: 2796 AA [This is the length of the unprocessed precursor] Molecular weight: 315100 Da [This is the MW of the unprocessed precursor] CRC64: 02AE740706AC29E7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MCVIQRLTYA YLIRTSLNDK ACHKIFESLF RFISVERSLY NRASSKGACA SRLSACASVI 

        70         80         90        100        110        120 
RTAINVFLRN LRTKSIRAIV DHITEILQVP GEGLWEHLGA DYLKCLTTLL RYPPHLEHLA 

       130        140        150        160        170        180 
ANEWDKVLNL CLRSIGAPED GDSQSSDHNG HPSTLDDFLD ASSRSTPSRR TSSLALREKQ 

       190        200        210        220        230        240 
SGDKRIVAEA IVCIQLLTAT PTAPVQVAAE KVLRGLGTFL KLSPIAGSEH QAAFNSINTV 

       250        260        270        280        290        300 
VMRVIFDQSD LVRMFLLDLI PVIRHLWSTK LMGLKDELLV TILLCMIILT DATRRAPTDS 

       310        320        330        340        350        360 
LALSIENLLD TIYSEYTKRS EKDILQIDEL IFDRTSFTQI IDLALQPRLE VPRSEHNLTV 

       370        380        390        400        410        420 
VWVMAKLMRL SEESTAQLSH PAGETPSKKQ RLNSASDQVF RDCVMSSGNR RVCALQLIPI 

       430        440        450        460        470        480 
LLQGRLTMES KASLLQRLIP YILDDNGVIA SWTMVAISSI SDSSLELWAI ITRLCAQTNP 

       490        500        510        520        530        540 
GSVSNASKQI CSWLREAWVI GTVTDRIQTA QVAAFARPLD LLNLFLACTN RQFEMPTPQF 

       550        560        570        580        590        600 
RGPSGIVAKG WHFYQSNREL LHYLFHVDGM LVPSSLHGRD DCISLQLATR KDHNDDIVLD 

       610        620        630        640        650        660 
LLQAKSEMFL QAWRSVSDSK SHHVTVDVVQ ILASFCIVAV LYTECIPEQL HTQIKDLRGN 

       670        680        690        700        710        720 
IQQLWDSLCS FMASRELVFV QYCLELLCPF LPQGGRVGFE KSVVNSSLYR LVSPLGAILE 

       730        740        750        760        770        780 
NHRQDQKRLL SSDEEEPMDL DDQLLQSNDL LAENMCIINS NRESVPLFHD SATFQRSMTI 

       790        800        810        820        830        840 
RLSIFNIAYG SVVQPDQPAR SALVEYLTDL DEADILSSKD FLPDVYRACA GYERTSLLDL 

       850        860        870        880        890        900 
LEDMGEKCLQ TYQLERCETS QVLCIHMLDS FIKSWTTGDG DHLSDSASDI YNWVTDVLLV 

       910        920        930        940        950        960 
NGRASSRVSI AFSRLLEEIF STNPAYTSGE SNPSPRTTLF MILQESDILT KYNVGNLVPK 

       970        980        990       1000       1010       1020 
LFRHFPLKDH DAIFDDILES LPRDPDWTEG IALRLFILAR LASQWHTLLR RSIYHMFETP 

      1030       1040       1050       1060       1070       1080 
AQLPHSRWHA EKCIRHVASV FGLEDARQLF RLFSSQILYT WTENESVMTM PFSIFGYSTL 

      1090       1100       1110       1120       1130       1140 
EDMLSDVQDE IVGQIMMRAN EHEASELSTR LKIPFIELLA TSFYKAEAYS IARDISTPPG 

      1150       1160       1170       1180       1190       1200 
QSSQPKGVEN RLKKILGADR FVSLVEKQFP QVIATFFGTL DQCEQIERAF SKRANFQEAF 

      1210       1220       1230       1240       1250       1260 
SILKSITAKG ASKEILPPNQ QPSFRARYLL DELEFLCKRS GYELETIWTP TLASYVCRTL 

      1270       1280       1290       1300       1310       1320 
LESIHPALGS LHACSVIRKI RILICITGPV MLRDYPFEML LHALRPFLTD IHCSEDALGM 

      1330       1340       1350       1360       1370       1380 
FWYLLDAGRS YLTENPSFTA GIAVSTLLSF RKFLASTSAT MQESESVAVL TIVQTFLQWF 

      1390       1400       1410       1420       1430       1440 
EDYLKSYESP HLSPEAHAFF QRLMESSRRI STPDKELDGT EECNLLLEVI QDRNSKTRLL 

      1450       1460       1470       1480       1490       1500 
SQSISDHILS LLCASFKSAP NYHQGLVERG YDAIADSVAL YQTLQDFSPT KEYRLWAARV 

      1510       1520       1530       1540       1550       1560 
IGRNFAATGM ISDDLLREQQ STLFEPRMAK LSLHMSCQSK ARILQVLCSM LQNSSPLEVG 

      1570       1580       1590       1600       1610       1620 
LVERTLQLIV SNLAGAPGFE NYEEIISPSL LKALIWSPYQ CPSIPLPASQ TKNHDTIVRW 

      1630       1640       1650       1660       1670       1680 
NPGISFAHWA RSIGLFLTKA APQDPVIGPL RNILHVIPSL AVRILPYILH DVLLTEPDGV 

      1690       1700       1710       1720       1730       1740 
ANVRKTISDV FQQGLHEADA HSIPHVRLII NCLLYLRNQP RPQEATIVER DEWLEIDFAV 

      1750       1760       1770       1780       1790       1800 
ASRAANTCGL PKTALLFLEI QASRAVSGSR RSSLVKYEPP PDLLHDIFRN VDDPDLFYGV 

      1810       1820       1830       1840       1850       1860 
QQSSSLESVM ETLEHESSGF KNLLFQSAQY DCEIQMSGDA DAHGLLKALN SSNLQGIANS 

      1870       1880       1890       1900       1910       1920 
LTSTLRGSKS SVSFDSMMQA AIDLRQWDLP VSPMNHSPSA ALFRTFQSLN TSTSLVDVSN 

      1930       1940       1950       1960       1970       1980 
SVNESLLAIL GSLGSTSRSA MSFRAAMRDL GIVTEISDVL SATSLEELSE EWRKIAERNS 

      1990       2000       2010       2020       2030       2040 
WLKATSVDEV GEILKCHEAL FSSIKTRDYL KSAVGLSDRD AQLLEVKVIR QSLSITRSHG 

      2050       2060       2070       2080       2090       2100 
IPQVSLKSAM RLSKLADLCV VQGINVEGAT KFDLANVLWD QGEMAASIRM LQQLDNQGDL 

      2110       2120       2130       2140       2150       2160 
HKQAIPISRP ELLVTLGHHV AEARLEKPEA IIQGYLGPAV KELKNRSEAE EAGRVYHGFA 

      2170       2180       2190       2200       2210       2220 
TFCDQQLQNP DGLEDFRRAE QLRNRKEKEV LGLEEMMKNA EGKEREALRH YRTKTKQWFD 

      2230       2240       2250       2260       2270       2280 
LDDREYQRLR RSREAFLQQC LENYLLCLKE SDMYNNDALR FCALWLGKSD SEIANKAVSK 

      2290       2300       2310       2320       2330       2340 
YLNQVPSRKF APLMNQLTSR LQDTSDEFQN MLFALIFRIC VEHPFHGMYQ IFASSKSKGG 

      2350       2360       2370       2380       2390       2400 
KDPSALSRNR AASRLVDCLK NDKRIGPTWV AVHNANISYV RFAVDRLDEK VKSGAKVPLK 

      2410       2420       2430       2440       2450       2460 
KLLTGQRLEQ DASTQKLPPP TMKIAIRVDC DYSEIPKLVR YHPEFTVASG VSAPKIVTAV 

      2470       2480       2490       2500       2510       2520 
ATDGHKYKQL FKGGNDDLRQ DAIMEQVFEQ VSSLLKDHQA TQQRKLGIRT YKVLPLTSNA 

      2530       2540       2550       2560       2570       2580 
GIIEFVPHTI PLHDYLMPAH QRYFPKDMKP NMCRKHISDV QTRSFEQRVK TFRQITEHFH 

      2590       2600       2610       2620       2630       2640 
PVMRYFFMEK FNSPDDWFSK RLSYTRSTAA ISILGHVLGL GDRHGHNILL DERTGEVVHI 

      2650       2660       2670       2680       2690       2700 
DLGVAFEQGR VLPVPEVVPF RLTRDLVDGM GITKTEGVFR RCCEFTLEAL RQESYSIMTI 

      2710       2720       2730       2740       2750       2760 
LDVLRYDPLY SWTLSPLRMK RMQDAQEAGD GPPMISGAAE DQRSANEPSE ADRALTVVAK 

      2770       2780       2790 
KLSKTLSVTA TVNELIQQAT DERNLAVLYC GWAAYA
Q4WVM7 in FASTA format

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