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UniProtKB/Swiss-Prot entry Q4TWH8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NS1AB_HASV5
Primary accession number Q4TWH8
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on April 8, 2008 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 18)
Name and origin of the protein
Protein name Non-structural polyprotein 1AB
Synonyms None
Contains Protein p19
Transmembrane protein 1A
Serine protease p27
     (p27)
     (EC 3.4.21.-)
Protein p20
RNA-directed RNA polymerase p57
     (p57)
     (EC 2.7.7.48)
Gene name
Name: ORF1
From
Human astrovirus-5 (HAstV-5) [TaxID: 35741] 
Taxonomy Viruses; ssRNA positive-strand viruses, no DNA stage; Astroviridae; Mamastrovirus.
Virus host Homo sapiens (Human) [TaxID: 9606]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Goiania/GO/12/94/Brazil;
DOI=10.1007/s00705-005-0704-9; PubMed=16421636 [NCBI, ExPASy, EBI, Israel, Japan]
Silva P.A., Cardoso D.D., Schreier E.;
"Molecular characterization of human astroviruses isolated in Brazil, including the complete sequences of astrovirus genotypes 4 and 5.";
Arch. Virol. 151:1405-1417(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
DQ028633; AAY46273.1; ALT_SEQ; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q4TWH8.
Family and domain databases
InterPro IPR001205; RNA_pol_P3D.
IPR007094; RNA_pol_PSvir.
Graphical view of domain structure.
Pfam PF00680; RdRP_1; 1.
Pfam graphical view of domain structure.
PROSITE PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q4TWH8.
Other
ProtoNet Q4TWH8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Coiled coil; Hydrolase; Membrane; Nucleotide-binding; Nucleotidyltransferase; Protease; Ribosomal frameshifting; RNA replication; RNA-directed RNA polymerase; Thiol protease; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1416  1416     Non-structural polyprotein 1AB. PRO_0000327283
CHAIN   1    175  175     Protein p19 (Potential). PRO_0000327284
CHAIN   176    419  244     Transmembrane protein 1A (Potential). PRO_0000327285
CHAIN   420    664  245     Serine protease p27 (Potential). PRO_0000327286
CHAIN   665    913  249     Protein p20 (Potential). PRO_0000327287
CHAIN   914   1416  503     RNA-directed RNA polymerase p57 (Potential). PRO_0000327288
TRANSMEM   154    174  21     Potential. 
TRANSMEM   239    259  21     Potential. 
TRANSMEM   286    306  21     Potential. 
TRANSMEM   313    333  21     Potential. 
TRANSMEM   344    364  21     Potential. 
DOMAIN   1161   1287  127     RdRp catalytic. 
COILED   104    146  43     Potential. 
COILED   587    614  28     Potential. 
ACT_SITE   461    461        Charge relay system; for serine protease activity (By similarity). 
ACT_SITE   489    489        Charge relay system; for serine protease activity (By similarity). 
ACT_SITE   551    551        Charge relay system; for serine protease activity (By similarity). 
SITE   175    176  2     Cleavage (Potential). 
SITE   419    420  2     Cleavage (Potential). 
SITE   664    665  2     Cleavage (Potential). 
SITE   913    914  2     Cleavage (Potential). 
Sequence information
Length: 1416 AA [This is the length of the unprocessed precursor] Molecular weight: 161728 Da [This is the MW of the unprocessed precursor] CRC64: CB75E8DC9B60DE0D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAHGEPYYSS KPDKDFNFGS TMARRQMTPT MVTKLPKFVR NSPQVYDWIV RGLIFPTTGK 

        70         80         90        100        110        120 
TYFQRVVVIT GGFEDGTYGS FAFDGREWVE IYPIEHLNLM SSLKLIHKAN ALQERLRLSQ 

       130        140        150        160        170        180 
EEKATLTLDV QFLQHENVRL KELISKPEPR KIQMKWIIVG AVLTFLSLIP GGYAQSQTNN 

       190        200        210        220        230        240 
TIFTDVIAAC KYSTETLTEN LDLRIKLALA NITISDKLDA VRQILNFAFV PRSHWLRTVF 

       250        260        270        280        290        300 
YYIHYYEMWN IFMFVLAIGT VMRSTRPGTD LITLATSHLS GFRMAVLPTI PFHTTMTLWV 

       310        320        330        340        350        360 
MNTLMVCYYF DNLLAITMAI LAPILGIIFL CFMEDSNYVS QIRGLIATAV LIAGGHACLT 

       370        380        390        400        410        420 
LTGTTTSLFV VILTCRFVRM ATIFIGTRFE IRDANGKVVA TVPTRIKNAA FDFFQRLKQS 

       430        440        450        460        470        480 
GVRVGVNEFV VIKPGALCVI DTPEGKGTGF FSGNDIVTAA HVVGNNTFVN VCYEGLMYEA 

       490        500        510        520        530        540 
KVRYMPEKDI AFITCPGDLH PTARLKLSKN PDYSCVTVMA YVNEDLVVST AAAMVHGNTL 

       550        560        570        580        590        600 
SYAVRTQDGM SGAPVCDKYG RVLAVHQTNT GYTGGAVIID PADFHPVKAP SQVELLKEEI 

       610        620        630        640        650        660 
ERLKAQLNSA AENPSTVITQ QPTATLEQKS VNDSDVVDLV RTAMEREMKI LRDEINGILA 

       670        680        690        700        710        720 
PFLQKKKGKT KHGRGRVRRN LRKGVKLLTE EEYRELLEKG LDRETFLDLI DRIIGERSGY 

       730        740        750        760        770        780 
PDYDDEDYYD EDDDGWGMVG DDVEFDYTEV INFDQAKPTP APRTTKPKPC PEPEAETQPL 

       790        800        810        820        830        840 
DLSQKKDKQL EHEQQVVKPT KPQKNDPQPY SQTYGKAPIW ESYDFDWDED DAKFILPAPP 

       850        860        870        880        890        900 
RLTKADEIVL GSKIVKLRTI IETAIKTQNY SALPEAVFEL DKAAYEAGLE GFLQRVKSKN 

       910        920        930        940        950        960 
KAPKKLQRAP EDQGAQNYHS LDAWKSLLEP PRERRCVPAN FPLLGHLPID RPIFDDKKPR 

       970        980        990       1000       1010       1020 
DDLLGLLPEP TWHAFEEYGP TTWGPQAFIK SFDKFFYAEP IDFFSEYPQL CAFADWATYR 

      1030       1040       1050       1060       1070       1080 
EFRYLEDTRV IHITATEKNT DSTPAYPKMN YFDTEEKYLE SYGWAPYIRE FTRVFKGDKP 

      1090       1100       1110       1120       1130       1140 
EVLWYLFLKK EIIKEEKIRN SDIRQIVCAD PIYTRIGACL EAHQNALMKQ HTETSVGQCG 

      1150       1160       1170       1180       1190       1200 
WSPMEGGFKK TMQRLVNKGN KYFIEFDWTR YDGTIPPSLF RHIKEIRWNF INKDQREKYR 

      1210       1220       1230       1240       1250       1260 
HVHEWYVDNL LNRHVLLPSG EVTLQTRGNP SGQFSTTMDN NMINFWLQAF EFAYFNGPNK 

      1270       1280       1290       1300       1310       1320 
DLWKTYDTVV YGDDRLSTTP SVPENYEERV IDMYRDIFGM WVKPGKVICR ESIVGLSFCG 

      1330       1340       1350       1360       1370       1380 
FTVNADLEPV PTSPEKLMAS LLKPYKILPD LESLHGKLLC YQLLAAFMAE DHPFKVYVEH 

      1390       1400       1410 
CLSRTAKQLR DSGLPARLTE EQLHRIWRGG PKKCDG
Q4TWH8 in FASTA format

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View entry in raw text format (no links)
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