[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; International consortium for macaque cDNA sequencing and analysis; "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."; Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: (S)-lactate + NAD⁺ = pyruvate + NADH.
PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1 .
SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB168645; BAE00756.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q4R816; 51-380.

ModBase

Q4R816.

Family and domain databases

InterPro

IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000102; Lac_mal_DH; 1.

PRINTS

PR00086; LLDHDRGNASE.

TIGRFAMs

TIGR01771; L-LDH-NAD; 1.

PROSITE

PS00064; L_LDH; 1.

BLOCKS

Q4R816.

Phylogenomic databases

HOVERGEN

Q4R816; -.

Other

ProtoNet

Q4R816.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glycolysis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 381`	`381`	`L-lactate dehydrogenase A-like 6B.`	`PRO_0000261002`
`NP_BIND`	`101 106`	`6`	`NAD (By similarity).`
`ACT_SITE`	`242 242`		`Proton acceptor (By similarity).`
`BINDING`	`148 148`		`NAD (By similarity).`
`BINDING`	`155 155`		`Substrate (By similarity).`
`BINDING`	`187 187`		`NAD or substrate (By similarity).`
`BINDING`	`218 218`		`Substrate (By similarity).`
`BINDING`	`297 297`		`Substrate (By similarity).`

Sequence information

Length: 381 AA [This is the length of the unprocessed precursor]

Molecular weight: 42049 Da [This is the MW of the unprocessed precursor]

CRC64: 9D394077C58B634F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSWTVPLVRA SQRVSSVGAN FLCLKMALCP RQAARIPLKG AWRFTSVSKM ATVKSELIER 

        70         80         90        100        110        120 
FTSEEPVHHS KVSIIGTGSV GMACAISILL KGLIDELALV DLDEGKLKGE TMDLQHGSSF 

       130        140        150        160        170        180 
TKMPNIVCSK DYFVTANSNL VIITAGARQE KGETRLNLVQ RNVALFKLMI SNIVQHSPHC 

       190        200        210        220        230        240 
KLIIVSNPVD ILSYVAWKLS AFPKNRVIGS GCNLDTARFR FLIGQKLGIH SESCHGWILG 

       250        260        270        280        290        300 
EHGDSSVPVW SGVNIAGVPL KDLNSDIGTD KDPEQWKNVH EEVIATAYEI IKMKGYTSWA 

       310        320        330        340        350        360 
IGLSVADLTE SILKNLRRTH PVSTIIKGLY GIDEEVFLSI PCILGENGIT HLIKIKLTPE 

       370        380 
EEDRLKKSAK TLWEIQKELK I

Q4R816 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools